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SKIL

  • Official Full Name

    SKI-like oncogene

  • Overview

    The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
  • Synonyms

    SKIL; SKI-like oncogene; ski-like protein; SNO; SnoA; SnoN; ski-related oncogene snoN; SnoI;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SKIL-27723TH Recombinant Human SKIL Wheat Germ N/A 684 amino acids
Human SKIL-27724TH Recombinant Human SKIL Wheat Germ N/A 78 amino acids
Human SKIL-2688H Recombinant Human SKIL, His-tagged E.coli His 335-684aa
Human SKIL-1814HCL Recombinant Human SKIL 293 Cell Lysate HEK293 N/A
Human SKIL-478HF Recombinant Full Length Human SKIL Protein In Vitro Cell Free System 684 amino acids
Chicken SKIL-6729C Recombinant Chicken SKIL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SKIL involved in several pathways and played different roles in them. We selected most pathways SKIL participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKIL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsPIK3CD;AXIN2;FGF2;AXIN1;MAPK13;TCF3;MAP2K2;ESRRB;FZD9

SKIL has several biochemical functions, for example, NOT DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SKIL itself. We selected most functions SKIL had, and list some proteins which have the same functions with SKIL. You can find most of the proteins on our site.

Function Related Protein
NOT DNA bindingSKIL;NFIB;MBD5;XRCC4;TINF2;HIPK2
RNA polymerase II core promoter proximal region sequence-specific DNA bindingFOXJ2;ELF3;T;ZNF562;CEBPB;HNRNPC;NKX6-1;ELF1;HELT
SMAD bindingHIPK2;SKIL;PURA;BMPR1A;TGFBR1;BMPR1B;SOD3;ACVR1B;TCF12
chromatin bindingAPITD1;YBX2;HOXD10;UPF1;SAFB;ACTL6A;SIRT6;STAT5B;KDM1A
protein bindingMAP2K5;CIC;CCR1;TADA2A;ASPH;INSIG2;FBXO28;DCTN4;CCL3
protein complex bindingTG;MTHFR;PPP4C;CPD;Casp3;KCTD5;AP2A2;HCLS1;ITGB1BP1
protein domain specific bindingZNF521;VPS4A;MYH9;BHLHE40;RCC2;HSPA5;FOXH1;YWHAZ;TACC1
transcription corepressor activityKCNIP3;BCL11A;ZFPM2;ZHX3;ENO1;ZFPM1;MXD4;CREG1;HOXC6
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingGATA3;HAND1;IFI203;RELA;ZNF148;GCFC2;ZFP536;MXD1;ESRRA

SKIL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKIL here. Most of them are supplied by our site. Hope this information will be useful for your research of SKIL.

OIP5; STK16; AES; VPS28; NXF3; DRG1; Ncor1

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