| Description : |
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
113.7 kDa |
| AA Sequence : |
MAELPTTETPGDATLCSGRFTISTL LSSDEPSPPAAYDSSHPSHLTHSST FCMRTFGYNTIDVVPTYEHYANSTQ PGEPRKVRPTLADLHSFLKQEGRHL HALAFDSRPSHEMTDGLVEGEAGTS SEKNPEEPVRFGWVKGVMIRCMLNI WGVILYLRLPWITAQAGIVLTWIII LLSVTVTSITGLSISAISTNGKVKS GGTYFLISRSLGPELGGSIGLIFAF ANAVGVAMHTVGFAETVRDLLQEYG APIVDPINDIRIIGVVSVTVLLAIS LAGMEWESKAQVLFFLVIMVSFANY LVGTLIPPSEDKASKGFFSYRADIF VQNLVPDWRGPDGTFFGMFSIFFPS ATGILAGANISGDLKDPAIAIPKGT LMAIFWTTISYLAISATIGSCVVRD ASGVLNDTVTPGWGACEGLACSYGW NFTECTQQHSCHYGLINYYQTMSMV SGFAPLITAGIFGATLSSALACLVS AAKVFQCLCEDQLYPLIGFFGKGYG KNKEPVRGYLLAYAIAVAFIIIAEL NTIAPIISNFFLCSYALINFSCFHA SITNSPGWRPSFQYYNKWAALFGAI ISVVIMFLLTWWAALIAIGVVLFLL LYVIYKKPEVNWGSSVQAGSYNLAL SYSVGLNEVEDHIKNYRPQCLVLTG PPNFRPALVDFVGTFTRNLSLMICG HVLIGPHKQRMPELQLIANGHTKWL NKRKIKAFYSDVIAEDLRRGVQILM QAAGLGRMKPNILVVGFKKNWQSAH PATVEDYIGILHDAFDFNYGVCVMR MREGLNVSKMMQAHINPVFDPAEDG KEASARGARPSVSGALDPKALVKEE QATTIFQSEQGKKTIDIYWLFDDGG LTLLIPYLLGRKRRWSKCKIRVFVG GQINRMDQERKAIISLLSKFRLGFH EVHILPDINQNPRAEHTKRFEDMIA PFRLNDGFKDEATVNEMRRDCPWKI SDEEITKNRVKSLRQVRLNEIVLDY SRDAALIVITLPIGRKGKCPSSLYM AWLETLSQDLRPPVILIRGNQENVL TFYCQTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
