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SNX12

Official Full Name

sorting nexin 12
Overview

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function.
Synonyms

SNX12; sorting nexin 12; sorting nexin-12; 2610001F05Rik; AW045757; MGC118982; MGC118983; RGD1565585; RP23-356J7.1; SDP8; SNX 12; SNX12_HUMAN; OTTHUMP00000023487; OTTHUMP00000023488;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SNX12-1601HCL	Recombinant Human SNX12 293 Cell Lysate	HEK293	Non	Inquiry
Human	SNX12-5648H	Recombinant Human SNX12 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK	Inquiry
Mouse	Snx12-6022M	Recombinant Mouse Snx12 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK	Inquiry
Rhesus Macaque	SNX12-4389R	Recombinant Rhesus monkey SNX12 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	SNX12-4205R	Recombinant Rhesus Macaque SNX12 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Rhesus Macaque	SNX12-4205R-B	Recombinant Rhesus Macaque SNX12 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SNX12-7395Z	Recombinant Zebrafish SNX12	Mammalian Cell	His	Inquiry
Zebrafish	SNX12-7396Z	Recombinant Zebrafish SNX12	Mammalian Cell	His	Inquiry
Zebrafish	SNX12-7397Z	Recombinant Zebrafish SNX12	Mammalian Cell	His	Inquiry
Zebrafish	SNX12-11345Z	Recombinant Zebrafish SNX12	Mammalian Cell	His	Inquiry
Chicken	SNX12-3177C	Recombinant Chicken SNX12	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SNX12 involved in several pathways and played different roles in them. We selected most pathways SNX12 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	ARAP2;HLA-F;VPS26A;FGFR2;HLA-E;HRASB;RAB11FIP4A;ASAP1;LDLRAP1B

SNX12 has several biochemical functions, for example, enzyme binding, phosphatidylinositol binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX12 itself. We selected most functions SNX12 had, and list some proteins which have the same functions with SNX12. You can find most of the proteins on our site.

Function	Related Protein
enzyme binding	HDAC10;C6orf211;ATP2A2;HAND1;FOXO4;MDM4;HOXA9;SELS;SUPT5H
phosphatidylinositol binding	PXK;NOXO1A;SNX5;SNX32;PLD2;SNX31;SNX17;WDR35;SH3PXD2AA
protein binding	HIST4H4;AGBL1;EIF3F;POLR1B;OSTB;TPD52L2;PEX2;ATRNL1;TRAPPC6B

SNX12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX12.

ARL6IP1; ABL1; FYN; NCK1; GRB2; pi3p; CDC5L

Research Area

Wang, X; Huang, T; et al. Dysregulation of protein trafficking in neurodegeneration. MOLECULAR NEURODEGENERATION 9:-(2014).

Angel, JM; Abel, EL; et al. Fine Mapping Reveals That Promotion Susceptibility Locus 1 (Psl1) Is a Compound Locus With Multiple Genes That Modify Susceptibility to Skin Tumor Development. G3-GENES GENOMES GENETICS 4:1071-1079(2014).