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SNX9

Official Full Name

sorting nexin 9
Overview

This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]
Synonyms

SNX9; sorting nexin 9; SDP1; WISP; SH3PX1; SH3PXD3A; sorting nexin-9; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; Wiskott-Aldrich syndrome protein (WASP) interactor protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian cells

Tag

Flag
His
Fc
Avi
T7
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SNX9-1367H	Recombinant Human SNX9 protein, His & T7-tagged	E.coli	His&T7	Phe250~Met595	Inquiry
Human	SNX9-1584HCL	Recombinant Human SNX9 293 Cell Lysate	HEK293	Non		Inquiry
Human	SNX9-536HFL	Recombinant Full Length Human SNX9 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	SNX9-5901H	Recombinant Human SNX9 Protein (Phe250-Met595), N-His tagged	E.coli	His	Phe250-Met595	Inquiry
Human	SNX9-3536H	Recombinant Human SNX9 protein, His-tagged	E.coli	His	1-362 aa	$319 / 25μg
Human	SNX9-2066H-B	Recombinant Human SNX9 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	SNX9-2066H	Recombinant Human SNX9 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	Snx9-6039M	Recombinant Mouse Snx9 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SNX9 involved in several pathways and played different roles in them. We selected most pathways SNX9 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Clathrin derived vesicle budding	AP3S1;YIPF6;CNO;SNX9B;BLOC1S1;PICALM;AP4B1;TBC1D8B;CLVS2
Golgi Associated Vesicle Biogenesis	AP1S3A;BLOC1S4;DTNBP1B;CLINT1;HIP1RB;AP1M2;PPIAL4A;SNX9B;PUM1
Membrane Trafficking	TRAPPC6B;NAPAA;TRAPPC4;STAM2;SNAPIN;PUM1;TRAPPC1;TGOLN2;BLOC1S1
Vesicle-mediated transport	PICALM;SEC22C;DTNBP1;SH3D19;SNX9;COPB1;MYO6A;YIPF6;TPD52
trans-Golgi Network Vesicle Budding	PICALMA;TFR1B;CLVS1;CNO;PICALM;TPD52;SNX9A;BLOC1S3;BLOC1S6

SNX9 has several biochemical functions, for example, 1-phosphatidylinositol binding, Arp2/3 complex binding, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX9 itself. We selected most functions SNX9 had, and list some proteins which have the same functions with SNX9. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol binding	CCDC167;SCARB1;FRMPD2;PLEKHA4;PICALMB;WDFY3;PLEKHA3;PLEKHA2;MCF2L
Arp2/3 complex binding	WHAMM;ARPC2;PICK1;HAND2;GMFG;GMFB;SNX9;CORO1B
phosphatidylinositol binding	GRB7;SNX31;ITPR1;ITPR3;SNX4;SNX7;AKR1C1;SNX22;RAG2
protein binding	NPLOC4;TRPC5;SIGLEC8;ITGA6;DYNLT1;NCK2;MLH1;IL6ST;CCT8
protein homodimerization activity	RXRB;HMOX1;ABCD3;OLIG2;USH1G;SRM;PVRL3;FLNA;SNX1
ubiquitin protein ligase binding	CUL2;CUL3;HSPA9;GGN;MAP1LC3C;CUL1A;ACTG1;HERC2;RANGAP1

SNX9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX9.

DNM1; DNM2; ITCH; espF

Research Area

Tahoun, A; Siszler, G; et al. Comparative Analysis of EspF Variants in Inhibition of Escherichia coli Phagocytosis by Macrophages and Inhibition of E. coli Translocation through Human- and Bovine-Derived M Cells. INFECTION AND IMMUNITY 79:4716-4729(2011).

Macaulay, SL; Stoichevska, V; et al. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. BIOCHEMICAL JOURNAL 376:123-134(2003).