SNX9

  • Official Full Name

    sorting nexin 9

  • Overview

    This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]
  • Synonyms

    SNX9; sorting nexin 9; SDP1; WISP; SH3PX1; SH3PXD3A; sorting nexin-9; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; Wiskott-Aldrich syndrome protein (WASP) interactor protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SNX9-1367H Recombinant Human SNX9 protein, His & T7-tagged E.coli His/T7 Phe250~Met595 (Accession # Q9Y5X1)
Human SNX9-1584HCL Recombinant Human SNX9 293 Cell Lysate HEK293 N/A
Human SNX9-536HFL Recombinant Full Length Human SNX9 Protein, C-Flag-tagged Mammalian cells Flag
Human SNX9-5901H Recombinant Human SNX9 Protein (Phe250-Met595), N-His tagged E.coli N-His Phe250-Met595
Human SNX9-3536H Recombinant Human SNX9 protein, His-tagged E.coli His 1-362 aa
Human SNX9-2066H-B Recombinant Human SNX9 Protein Pre-coupled Magnetic Beads HEK293
Human SNX9-2066H Recombinant Human SNX9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Snx9-6039M Recombinant Mouse Snx9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SNX9 involved in several pathways and played different roles in them. We selected most pathways SNX9 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Clathrin derived vesicle buddingSNX9B;NAPAB;TBC1D8B;ARF1;TCEAL4;DNASE2;TFR1B;FTH1A;YIPF6
Golgi Associated Vesicle BiogenesisFTH1A;BLOC1S3;TGOLN2;CPD;HIP1RB;AP3S1;CLINT1;AP1B1;BLOC1S6
Membrane TraffickingHIP1R;STAM2;TPD52L1;SNX9A;SEC22A;DNASE2;GJA5;AP3S1;TRAPPC6BL
Vesicle-mediated transportANKRD28;HSPH1;TCEAL4;COPB2;MYO6A;RALAB;PPP6C;BLOC1S4;HYOU1
trans-Golgi Network Vesicle BuddingHIP1R;BLOC1S4;TFR1B;DNASE2;HIP1RB;FTH1A;NECAP1;AP4B1;GAK

SNX9 has several biochemical functions, for example, 1-phosphatidylinositol binding, Arp2/3 complex binding, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX9 itself. We selected most functions SNX9 had, and list some proteins which have the same functions with SNX9. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol bindingSCIN;ZFYVE1;PLEKHA4;SYT1;SCARB1;EPB41;PICALMB;MCF2L;PLEKHA2
Arp2/3 complex bindingPICK1;HAND2;WHAMM;GMFB;ARPC2;GMFG;CORO1B;SNX9
phosphatidylinositol bindingARHGAP32;MITD1;SNX18B;SNX19A;SNX15;SLC12A9;SNX27A;SGK3;ITPR3
protein bindingFAM195B;ZFPM1;CCNE2;UGGT2;CD79B;SHPRH;SFPI1;MOS;IL33
protein homodimerization activityINHBB;TYW5;MYOM1;FLNA;BLOC1S6;NR2F2;NRBP1;SIAH1A;HPGDS
ubiquitin protein ligase bindingSMAD3;CUL1B;PIAS2;TXNIP;TMEM173;SCAMP3;UBXN1;PRR5L;PRKACB

SNX9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX9.

DNM1; DNM2; ITCH; espF

Research Area

Related articles

Tahoun, A; Siszler, G; et al. Comparative Analysis of EspF Variants in Inhibition of Escherichia coli Phagocytosis by Macrophages and Inhibition of E. coli Translocation through Human- and Bovine-Derived M Cells. INFECTION AND IMMUNITY 79:4716-4729(2011).
Macaulay, SL; Stoichevska, V; et al. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. BIOCHEMICAL JOURNAL 376:123-134(2003).
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