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SORCS1

Official Full Name

sortilin-related VPS10 domain containing receptor 1
Overview

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

SORCS1; sortilin-related VPS10 domain containing receptor 1; VPS10 domain-containing receptor SorCS1; VPS10 domain receptor protein SORCS 1; hSorCS; FLJ41758; FLJ43475; FLJ44957;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Human Cell
Mammalian Cell
Mammalian cells

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SORCS1-785H	Recombinant Human SORCS1	Mammalian Cell	His		Inquiry
Human	SORCS1-3791H	Recombinant Human SORCS1 protein, His-tagged	HEK293	His	Ser111-Ser1099	$623 / 50 µg
Human	SORCS1-2877H	Recombinant Human SORCS1, His-tagged	E.coli	His	33-156aa	$319 / 25μg
Human	SORCS1-1982HCL	Recombinant Human SORCS1 cell lysate	Human Cell	Non		Inquiry
Human	SORCS1-4102H	Recombinant Human SORCS1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	SORCS1-4102H-B	Recombinant Human SORCS1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Sorcs1-737M	Active Recombinant Mouse Sorcs1 Protein, His-tagged	Mammalian cells	His	Ser111-Ser1099	Inquiry
Mouse	Sorcs1-8574M-B	Recombinant Mouse Sorcs1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Sorcs1-8574M	Recombinant Mouse Sorcs1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SORCS1 involved in several pathways and played different roles in them. We selected most pathways SORCS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SORCS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SORCS1 has several biochemical functions, for example, neuropeptide receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SORCS1 itself. We selected most functions SORCS1 had, and list some proteins which have the same functions with SORCS1. You can find most of the proteins on our site.

Function	Related Protein
neuropeptide receptor activity	GPR139;NPFFR2;KISS1RB;PRLHR;NPFFR2.1;KISS1R;NPBWR1;HCRTR2;NPFFR1L3
protein binding	PRDX1;PTK2;RAPGEF4;EIF1AX;WDR61;DNA2;MEA1;PTGES2;SPRY4

SORCS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORCS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SORCS1.

Research Area

VPS10P-domain Family

Lane, RF; Gatson, JW; et al. Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. MOLECULAR NEURODEGENERATION 5:-(2010).

Hermey, G; Keat, SJ; et al. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. JOURNAL OF BIOLOGICAL CHEMISTRY 278:7390-7396(2003).