|Official Full Name||Sp2 transcription factor|
|Background||This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.|
|Synonyms||SP2; Sp2 transcription factor; transcription factor Sp2; KIAA0048; OTTHUMP00000196580; SP2_HUMAN; SPECIFICITY PROTEIN 2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SP2 involved in several pathways and played different roles in them. We selected most pathways SP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
SP2 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP2 itself. We selected most functions SP2 had, and list some proteins which have the same functions with SP2. You can find most of the proteins on our site.
|DNA binding||KCNA3; HIST1H47; INSM2; RBM5; HIST1H4I; ZNF12; ABI2; C14orf43; BRCA1; TCEA3|
|RNA polymerase II transcription factor activity, sequence-specific DNA binding||ZNF131; JUN; MAZ; FOXO1; RUNX2B; ELF2B; ZNF488; ETV2; FOXB1A; SOX14|
|histone deacetylase binding||CCND1; TRAF6; WDTC1; D7ERTD443E; NR2E1; NKX2-5; NR2C1; DNMT3B; XBP1; SFPQ|
|metal ion binding||TRIM35-31; ACSM2; PHF2; ITGA10; NCALDA; PC; TCN2; TEC; TRIM30A; ZFP513|
|protein binding||AATF; KCNJ5; VPS72; FCER2; INHA; HNRNPU; NCOR1; GAGE2D; PIFO; KAT2A|
SP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP2.
BANP; MCM7; FHL2