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SPSB2

  • Official Full Name

    splA/ryanodine receptor domain and SOCS box containing 2

  • Overview

    This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants.
  • Synonyms

    SPSB2; splA/ryanodine receptor domain and SOCS box containing 2; SPRY domain-containing SOCS box protein 2; GRCC9; SSB 2; gene-rich cluster protein C9; SPRY domain-containing SOCS box protein SSB-2; SSB2; MGC2519; FLJ17395;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPSB2-7212H Recombinant Human SplA/ryanodine Receptor Domain And SOCS Box Containing 2, His-tagged E.coli His 1-263aa
Human SPSB2-2942H Recombinant Human SPSB2, His-tagged E.coli His C-152aa
Human SPSB2-1486HCL Recombinant Human SPSB2 293 Cell Lysate HEK293 N/A
Human SPSB2-5319H Recombinant Human SPSB2 Protein, GST-tagged Wheat Germ GST
Mouse SPSB2-15951M Recombinant Mouse SPSB2 Protein Mammalian Cell His
Mouse Spsb2-1060M Recombinant Mouse Spsb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse SPSB2-8692M-B Recombinant Mouse SPSB2 Protein Pre-coupled Magnetic Beads HEK293
Mouse SPSB2-8692M Recombinant Mouse SPSB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPSB2-5726R Recombinant Rat SPSB2 Protein Mammalian Cell His
Rat SPSB2-5385R Recombinant Rat SPSB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPSB2-5385R-B Recombinant Rat SPSB2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SPSB2 Related Articles

SPSB2 involved in several pathways and played different roles in them. We selected most pathways SPSB2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPSB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemTHEM4;SH3RF1;CD300LB;NRG4;ERAP1;UBE2E3;CD300C;LILRB3;KLRG1
Antigen processing: Ubiquitination &ampWSB1;RNF41;WWP1;TRIM9;RBCK1;UBE2V1;TRIM63;UBE2U;GAN
Proteasome degradationFBXO17;RNF111;HUWE1;WWP1;TRIM69;MKRN1;ASB11;TPP2;PJA2
Class I MHC mediated antigen processing &ampCTSS;CD207;SEC23A;SPSB1;FBXO17;WSB1;FBXO27;ERAP1;RNF6
presentationRNF25;TRAF7;TRIM50;FCGR1B;ASB10;ASB9;UFL1;NPEPPS;UBR2
Immune SystemCTSH;GBP4;CLEC2B;SIGIRR;KIF11;GHRB;SIGLEC7;CTSLL;BTR29

SPSB2 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPSB2 itself. We selected most functions SPSB2 had, and list some proteins which have the same functions with SPSB2. You can find most of the proteins on our site.

Function Related Protein
molecular_functionCFAP36;SINUP;RFT1;TMEM106BB;CLHC1;TMEM97;MARCH9;GM1679;TMTC4
protein bindingFASN;COL4A3BP;ACE2;P2RX4;ZKSCAN1;ARVCF;VEGFB;AIRE;PIM1

SPSB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPSB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPSB2.

PIK3R3; vas; TCEB1; PRMT1; PAWR; GALNT15; TCEB2; CUL5; RNF7

Leung, EWW; Yagi, H; et al. F-19 NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2. CHEMICAL BIOLOGY & DRUG DESIGN 84:616-625(2014).
Yap, BK; Leung, EWW; et al. A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent. JOURNAL OF MEDICINAL CHEMISTRY 57:7006-7015(2014).
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