Recombinant Human SplA/ryanodine Receptor Domain And SOCS Box Containing 2, His-tagged

• Cat.No.: SPSB2-7212H
• Product Overview: Recombinant human SPSB2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 31.2 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-263aa
• Description: SPSB2 is a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This protein is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol,1mM DTT.
• Molecular Mass: 31.2 kDa (287aa), confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMGQTAL AGGSSSTPTP QALYPDLSCP EGLEELLSAP PPDLGAQRRH GWNPKDCSEN IEVKEGGLYF ERRPVAQSTD GARGKRGYSR GLHAWEISWP LEQRGTHAVV GVATALAPLQ TDHYAALLGS NSESWGWDIG RGKLYHQSKG PGAPQYPAGT QGEQLEVPER LLVVLDMEEG TLGYAIGGTY LGPAFRGLKG RTLYPAVSAV WGQCQVRIRY LGERRAEPHS LLHLSRLCVR HNLGDTRLGQ VSALPLPPAM KRYLLYQ
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 [ Homo sapiens ]
• Official Symbol: SPSB2
• Synonyms: SPSB2; splA/ryanodine receptor domain and SOCS box containing 2; SPRY domain-containing SOCS box protein 2; GRCC9; SSB 2; gene-rich cluster protein C9; SPRY domain-containing SOCS box protein SSB-2; SSB2; MGC2519; FLJ17395
• Gene ID: 84727
• mRNA Refseq: NM_001146316
• Protein Refseq: NP_001139788
• MIM: 611658
• UniProt ID: Q99619
• Chromosome Location: 12p13.31
• Pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: molecular_function; protein binding