STAG2

  • Official Full Name

    stromal antigen 2

  • Overview

    Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

  • Synonyms

    STAG2;stromal antigen 2;cohesin subunit SA-2;SA 2;SCC3B;SCC3 homolog 2;SA2;SA-2;bA517O1.1;FLJ25871;DKFZp686P168;DKFZp781H1753
Cat.# Product name Source (Host) Species Tag Protein Length Price
STAG2-2987H Recombinant Human STAG2, GST-tagged E.coli Human GST 1046-1171aa
STAG2-2438H Recombinant Human STAG2 protein, His-tagged E.coli Human His 1047-1172 aa
STAG2-16090M Recombinant Mouse STAG2 Protein Mammalian Cells Mouse His
STAG2-2740H Recombinant Human STAG2 Protein, His-tagged E.coli Human His Met1-Leu268
STAG2-8772M Recombinant Mouse STAG2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
STAG2-8772M-B Recombinant Mouse STAG2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    STAG2 involved in several pathways and played different roles in them. We selected most pathways STAG2 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cohesin Loading onto Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Meiosis MSH5,TINF2,MSH4,POT1,DIDO1,TEX15,SYCP2,SUN1,PSMC3IP,TEX12
    Cohesin Loading onto Chromatin STAG1,NIPBLB,MAU2,NIPBLA,PDS5B,NIPBL,WAPAL,PDS5A
    Meiotic synapsis POT1,SYNE2,SYCP1,SYCP2,SUN1,STAG1,FKBP6,TEX12,SYCE2,POT1A
    Cell cycle CCNH,CENPQ,PTTG2,GINS2,TP53BP1,NUP35,TUBGCP5,POT1,CLSPN,DSN1
    Cell Cycle, Mitotic B9D2,NDEL1,DULLARD,SPC25,MAU2,SGOL2,DSN1,CEP76,PCM1,GORASP2
    M Phase CDCA8,NIPBLB,ENSAB,ZWILCH,TMEM188,CENPP,CENPK,SPDL1,ZW10,STAG1
    Establishment of Sister Chromatid Cohesion PDS5A,STAG1,ESCO2,PDS5B,CDCA5,ESCO1,WAPAL

    Protein Function

    STAG2 has several biochemical functions, for example, chromatin binding,protein binding,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAG2 itself. We selected most functions STAG2 had, and list some proteins which have the same functions with STAG2. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding SRF,MAFGA,HOXD8,PPARG,ELF5,MAFF,ZGLP1,FOXO3,GATA5,ATF5
    protein binding WBP1L,ZFP346,MED7,SRGAP3,PVRL1,H2-AB1,FKBP7,DGCR6L,NOX5,FXYD6
    chromatin binding POLR2B,POU4F2,IFT74,JDP2,SUZ12,HMG20B,ATAD2,RCC1,PLAC8,MEOX1

    Interacting Protein

    STAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAG2.

    SMC3;RAD21;SMC1A

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