SUZ12

  • Official Full Name

    SUZ12 polycomb repressive complex 2 subunit

  • Overview

    This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
  • Synonyms

    SUZ12; SUZ12 polycomb repressive complex 2 subunit; CHET9; JJAZ1; polycomb protein SUZ12; chET 9 protein; joined to JAZF1 protein; suppressor of zeste 12 homolog; suppressor of zeste 12 protein homolog; chromatin precipitated E2F target 9 protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SUZ12-31487TH Recombinant Human SUZ12 Wheat Germ N/A 100 amino acids
Human SUZ12-1330HCL Recombinant Human SUZ12 293 Cell Lysate HEK293 N/A
Human SUZ12-35H Recombinant Human SUZ12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human SUZ12-763HFL Recombinant Full Length Human SUZ12 Protein, C-Flag-tagged Mammalian cells Flag
Human SUZ12-2744H Recombinant Human SUZ12 Protein, His-tagged E.coli N-His Leu448-Phe639
Human SUZ12-2141H-B Recombinant Human SUZ12 Protein Pre-coupled Magnetic Beads HEK293
Human SUZ12-2141H Recombinant Human SUZ12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Suz12-6234M Recombinant Mouse Suz12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SUZ12 involved in several pathways and played different roles in them. We selected most pathways SUZ12 participated on our site, such as Cellular Senescence, Cellular responses to stress, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUZ12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular SenescenceCDKN2C;ACD;H1F0;HIRA;E2F2;POT1;CDK4;HIST1H1D;CABIN1
Cellular responses to stressIGFBP7;TXNRD2;DYNLL2A;CDKN2C;CHMP4C;MAPKAPK2B;AMBRA1B;AMBRA1A;ATG4A
Chromatin modifying enzymesATF7IP;KDM2B;USP22;MTA1;ELP3;MCRS1;ZZZ3;BRPF3;MTA2
Chromatin organizationKIAA1267;CSRP2BP;ATXN7;C20orf20;KDM5BA;ANO9A;DMAP1;KDM2AA;ZZZ3
Epigenetic regulation of gene expressionRRP8;PHF19;SAP30L;H3F3D;PHF1;CD3EAP;SAP130;TET3;SIN3B
Gene ExpressionJUNB;ZNF92;TET3;ZNF257;NELFE;HNRNPR;EED;HNRNPUL1;RRP8
Oxidative Stress Induced SenescenceCBX8B;PHC3;PHC2;KDM6B;RING1;MINK1;CBX8;EED;RNF2
PKMTs methylate histone lysinesRBBP5;EED;SETD3;DPY30;PRDM16;SUZ12A;EHMT2;SMYD2A;AEBP2

SUZ12 has several biochemical functions, for example, RNA binding, RNA polymerase II core promoter sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUZ12 itself. We selected most functions SUZ12 had, and list some proteins which have the same functions with SUZ12. You can find most of the proteins on our site.

Function Related Protein
RNA bindingHNRNPK;FMR1;TERT;PATL1;ILF3;EIF5A;AHCYL1;EIF4G2A;HNRNPD
RNA polymerase II core promoter sequence-specific DNA bindingNSD1;H2AFY;NR4A2;STAT5A;H3F3B;ZFP335;TRP53;GATA6;SOX8
chromatin bindingJDP2;HMGA1;DMRT1;TDRD3;PRMT6;SLC30A9;RFX4;STAG1;MSH6
histone methyltransferase activitySUZ12;CARM1;PRMT2;EZH2;PRMT6;EED;PRMT1;SUV39H1;PRDM13
metal ion bindingSALL3;LMO4A;ESCO2;FRRS1;NUDT17;RRM2;ZFYVE16;ZNF80;NUDT8
methylated histone bindingRRP8;SPIN1;PHF1;FAM156A;CDYL2;ATRX;LOXL2;PHF8;CHD1
protein bindingSPRED1;HIST1H4K;C7orf53;C16orf70;MDH1;STX12;RERG;PPP4C;SIX4

SUZ12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUZ12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUZ12.

EZH2; CUL4B

Research Area

Related articles

Lee, CH; Hoang, LN; et al. Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement. MODERN PATHOLOGY 27:751-757(2014).
Hattori, N; Niwa, T; et al. Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. NUCLEIC ACIDS RESEARCH 41:7231-7239(2013).
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