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SUZ12

Official Full Name

SUZ12 polycomb repressive complex 2 subunit
Overview

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
Synonyms

SUZ12; SUZ12 polycomb repressive complex 2 subunit; CHET9; JJAZ1; polycomb protein SUZ12; chET 9 protein; joined to JAZF1 protein; suppressor of zeste 12 homolog; suppressor of zeste 12 protein homolog; chromatin precipitated E2F target 9 protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian cells
Wheat Germ

Tag

Flag
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A
N
His

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SUZ12-31487TH	Recombinant Human SUZ12	Wheat Germ	N/A	100 amino acids	Inquiry
Human	SUZ12-1330HCL	Recombinant Human SUZ12 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SUZ12-35H	Recombinant Human SUZ12 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Human	SUZ12-763HFL	Recombinant Full Length Human SUZ12 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	SUZ12-2744H	Recombinant Human SUZ12 Protein, His-tagged	E.coli	N-His	Leu448-Phe639	Inquiry
Human	SUZ12-2141H-B	Recombinant Human SUZ12 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	SUZ12-2141H	Recombinant Human SUZ12 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Suz12-6234M	Recombinant Mouse Suz12 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

SUZ12 involved in several pathways and played different roles in them. We selected most pathways SUZ12 participated on our site, such as Cellular Senescence, Cellular responses to stress, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUZ12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cellular Senescence	CDKN2C;ACD;H1F0;HIRA;E2F2;POT1;CDK4;HIST1H1D;CABIN1
Cellular responses to stress	IGFBP7;TXNRD2;DYNLL2A;CDKN2C;CHMP4C;MAPKAPK2B;AMBRA1B;AMBRA1A;ATG4A
Chromatin modifying enzymes	ATF7IP;KDM2B;USP22;MTA1;ELP3;MCRS1;ZZZ3;BRPF3;MTA2
Chromatin organization	KIAA1267;CSRP2BP;ATXN7;C20orf20;KDM5BA;ANO9A;DMAP1;KDM2AA;ZZZ3
Epigenetic regulation of gene expression	RRP8;PHF19;SAP30L;H3F3D;PHF1;CD3EAP;SAP130;TET3;SIN3B
Gene Expression	JUNB;ZNF92;TET3;ZNF257;NELFE;HNRNPR;EED;HNRNPUL1;RRP8
Oxidative Stress Induced Senescence	CBX8B;PHC3;PHC2;KDM6B;RING1;MINK1;CBX8;EED;RNF2
PKMTs methylate histone lysines	RBBP5;EED;SETD3;DPY30;PRDM16;SUZ12A;EHMT2;SMYD2A;AEBP2

SUZ12 has several biochemical functions, for example, RNA binding, RNA polymerase II core promoter sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUZ12 itself. We selected most functions SUZ12 had, and list some proteins which have the same functions with SUZ12. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	HNRNPK;FMR1;TERT;PATL1;ILF3;EIF5A;AHCYL1;EIF4G2A;HNRNPD
RNA polymerase II core promoter sequence-specific DNA binding	NSD1;H2AFY;NR4A2;STAT5A;H3F3B;ZFP335;TRP53;GATA6;SOX8
chromatin binding	JDP2;HMGA1;DMRT1;TDRD3;PRMT6;SLC30A9;RFX4;STAG1;MSH6
histone methyltransferase activity	SUZ12;CARM1;PRMT2;EZH2;PRMT6;EED;PRMT1;SUV39H1;PRDM13
metal ion binding	SALL3;LMO4A;ESCO2;FRRS1;NUDT17;RRM2;ZFYVE16;ZNF80;NUDT8
methylated histone binding	RRP8;SPIN1;PHF1;FAM156A;CDYL2;ATRX;LOXL2;PHF8;CHD1
protein binding	SPRED1;HIST1H4K;C7orf53;C16orf70;MDH1;STX12;RERG;PPP4C;SIX4

SUZ12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUZ12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUZ12.

EZH2; CUL4B

Research Area

Epithelial Stem Cell Transcription Factors

Epigenetics and EMT

Embryonic and Induced Pluripotent Stem Cell Markers

Pluripotent Stem Cell Transcription Factors

Lee, CH; Hoang, LN; et al. Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement. MODERN PATHOLOGY 27:751-757(2014).

Hattori, N; Niwa, T; et al. Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. NUCLEIC ACIDS RESEARCH 41:7231-7239(2013).