|Official Full Name||T, brachyury homolog (mouse)|
|Background||The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]|
|Synonyms||T; T, brachyury homolog (mouse); TFT; SAVA; brachyury protein; protein T; T brachyury homolog;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
t involved in several pathways and played different roles in them. We selected most pathways t participated on our site, such as Cardiac Progenitor Differentiation, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with t were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cardiac Progenitor Differentiation||BMP1; TBX20; T; SIRPA; NKX2; IRX4; ROR2; LIN28A; LIN28B; ZFP42|
|Regulation of Wnt-mediated beta catenin signaling and target gene transcription||KRT1; HBP1; KCNIP4; CYR61; ZCCHC12; TCF4; SALL4; TLE2; BCL9; T|
t has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by t itself. We selected most functions t had, and list some proteins which have the same functions with t. You can find most of the proteins on our site.
|RNA polymerase II activating transcription factor binding||IFI27; ATF2; TBX6; RB1; ISL1; HEY2; BHLHE40; LDB1; TBX20; SIN3A|
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||IRF1; ZNF664; DPF2; RELA; SOX10; EBF2; PGR; MESP1; KCNIP3; JUND|
|RNA polymerase II distal enhancer sequence-specific DNA binding||BACH1; NR1H4; PBX3; SFPI1; ATF2; REL; POU4F1; FLI1; RELA; JUN|
|RNA polymerase II transcription factor binding||GATA1A; TAL1; MIXL1; ZFPM1; NFATC1; ZFPM2; GFI1B; HCLS1; GATA5; SPI1|
|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding||RFX1; OLIG2; FOXC1; PAX3; LEF1; GATA6; MYOG; NR1H4; MITF; NR5A1|
|transcription factor activity, sequence-specific DNA binding||CRX; FOXN4; TEAD3B; EF1; HOXA5; TRPS1; MEF2A; FOXG1C; HLFA; HOXA3A|
|transcriptional repressor activity, RNA polymerase II transcription factor binding||AHRRA; RIMKLB; TBX6; BHLHE40; PITX2; MINA; ELP2; T; CREBBP; AHRRB|
t has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with t here. Most of them are supplied by our site. Hope this information will be useful for your research of t.