T

  • Official Full Name

    T, brachyury homolog (mouse)

  • Overview

    The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

  • Synonyms

    T;T, brachyury homolog (mouse);TFT;SAVA;brachyury protein;protein T;T brachyury homolog

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Enterobacteria phage T4
  • Bacteriophage K3
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • Mouse
  • Rat
  • E.coli
  • In Vitro Cell Free System
  • Insect Cells
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
T-16350M Recombinant Mouse T Protein Mammalian Cells Mouse His
T-27668TH Recombinant Human T Wheat Germ Human Non 377 amino acids
T-27672TH Recombinant Human T Wheat Germ Human Non 99 amino acids
T-6500C Recombinant Chicken T Mammalian Cells Chicken His
T-1294HCL Recombinant Human T 293 Cell Lysate HEK293 Human Non
DMAB32033 Mouse Anti-TRIM27 Monoclonal Antibody Mouse Human Non
DMAB36386 Rat Anti-Timd2 Monoclonal Antibody Rat Mouse Non
DMAB36387 Rat Anti-Timd2 Monoclonal Antibody Rat Mouse Non
RFL22746EF Recombinant Full Length Enterobacteria Phage T4 Lysis Protein(T) Protein, His-Tagged E.coli Enterobacteria phage T4 His Full L. Full Length (1-218)
T-130H Recombinant Human T Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
T-510HF Recombinant Full Length Human T Protein In Vitro Cell Free System Human Full L. 377 amino acids
T-6267M Recombinant Mouse T Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
T-754B Recombinant Bacteriophage K3 T protein, His&Myc-tagged E.coli Bacteriophage K3 His&Myc 50-218a.a.
T-8938M Recombinant Mouse T Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
T-8938M-B Recombinant Mouse T Protein Pre-coupled Magnetic Beads HEK293 Mouse
TNFRSF25-10H Active Recombinant Human TNFRSF25 Protein, hIgG/His-tagged Insect Cells Human Fc&His 417

    Involved Pathway

    T involved in several pathways and played different roles in them. We selected most pathways T participated on our site, such as Cardiac Progenitor Differentiation,Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with T were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cardiac Progenitor Differentiation BMP1,SOX1,LIN28A,NKX2,IRX4,NOG,ZFP42,TBX5,ROR2,SIRPA
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription SALL4,MYOG,IGF2BP1,CDX1,TNIK,TCF4,CYR61,HBP1,TLE1,AES

    Protein Function

    T has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by T itself. We selected most functions T had, and list some proteins which have the same functions with T. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II distal enhancer sequence-specific DNA binding PAX4,NR1H4,SPI1,TFAP2C,RXRB,MSC,NFE2L1,MIXL1,MEOX2,ARID3B
    transcription factor activity, sequence-specific DNA binding HOXA13,NR5A1B,POU3F4,HOXB7A,MSRB2,SS18L1,PPARDB,RARAA,BHLHE40,LHX1A
    transcriptional repressor activity, RNA polymerase II transcription factor binding ELP2,AHRRB,TBX6,CREBBP,MINA,AHRRA,BHLHE40,PITX2,AHRR,EOMES
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TEAD2,MEIS1,BHLHE40,CEBPB,MYOG,NFATC1,USF2,FOXF2A,MEF2C,GLI1
    RNA polymerase II activating transcription factor binding TP53BP1,IFI27,HEY2,SIN3A,HNF4A,TBX3,NHLH2,JUN,POU1F1,ZFPM1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding FOXD1,NR3C1,TBX15,ZNF562,IRF1,FEZF2,EGR2,JUND,MYBL2,ZNF114
    RNA polymerase II transcription factor binding GATA2B,TRPS1,ATF4,GATA2,NFATC1,SMAD4,SPOP,MKX,GATA6,HCLS1

    Interacting Protein

    T has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with T here. Most of them are supplied by our site. Hope this information will be useful for your research of T.

    Resources

    References

    • Yang, YR; Feng, JD; et al. Immune Responses to a Recombinant Rv0057-Rv1352 Fusion Protein of Mycobacterium tuberculosis. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:39-48(2015).
    • Law, JKY; Susloparova, A; et al. Human T cells monitored by impedance spectrometry using field-effect transistor arrays: A novel tool for single-cell adhesion and migration studies. BIOSENSORS & BIOELECTRONICS 67:170-176(2015).

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