|Official Full Name||T, brachyury homolog (mouse)|
|Background||The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]|
|Synonyms||T; T, brachyury homolog (mouse); TFT; SAVA; brachyury protein; protein T; T brachyury homolog;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
t involved in several pathways and played different roles in them. We selected most pathways t participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with t were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cardiac Progenitor Differentiation||IRX4; BMP1; TBX5; SOX1; TBX20; SIRPA; LIN28B; NKX2; ROR2; T|
|Regulation of Wnt-mediated beta catenin signaling and target gene transcription||CYR61; KCNIP4; TCF4; CBY1; AES; HBP1; BCL9; TNIK; TLE1; TLE4|
t has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by t itself. We selected most functions t had, and list some proteins which have the same functions with t. You can find most of the proteins on our site.
|RNA polymerase II activating transcription factor binding||SIN3A; TP53BP1; ZFPM1; RB1; BHLHE40; NHLH2; EOMES; HNF4A; CTNNB1; SETD3|
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||MYPOP; HNRNPK; FOXK2; EN1; PDX1; CREB1; MED8; PBX1; ATF3; GMEB1|
|RNA polymerase II distal enhancer sequence-specific DNA binding||FLI1; NR5A1; CDX2; NFE2L1; H3F3B; BACH1; GATA2; JUN; T; ARX|
|RNA polymerase II transcription factor binding||ATF4; ZGLP1; MEF2A; SMAD4; SPI1; PITX2; TP53; GATA2; MKX; DHX9|
|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding||GATA6; PKNOX1; LEF1; NKX2-5; CEBPA; AHR; SOX9; ATF1; NKX2-1; PROX1|
|transcription factor activity, sequence-specific DNA binding||SREBF1; HOXC4; RXRA; HSF2; CREB5; NFATC2; GATAD2B; ZNF550; FOXA3; HOXA6|
|transcriptional repressor activity, RNA polymerase II transcription factor binding||TBX6; ELP2; MLIP; EOMES; MINA; AHRR; CREBBP; AHRRB; T; RIMKLB|
t has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with t here. Most of them are supplied by our site. Hope this information will be useful for your research of t.