Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

TAF15

Official Full Name

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Overview

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.
Synonyms

TAF15; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; TAF2N, TATA box binding protein (TBP) associated factor, RNA polymerase II, N, 68kD (RNA binding protein 56); TATA-binding protein-associated factor 2N; hTAFII68; Npl3; RBP56; RNA binding protein 56; TAF; TAF2N; TAFII68; TAF(II)68; RBP56/CSMF fusion; TBP-associated factor 15; 68 kDa TATA-binding protein-associated factor; TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA box binding protein (TBP)-associated f;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TAF15-2466H	Recombinant human TAF15, His-tagged	E.coli	His	Inquiry
Human	TAF15-1274HCL	Recombinant Human TAF15 293 Cell Lysate	HEK293	N/A	Inquiry
Zebrafish	TAF15-4930Z	Recombinant Zebrafish TAF15	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

TAF15 involved in several pathways and played different roles in them. We selected most pathways TAF15 participated on our site, such as Basal transcription factors, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Basal transcription factors	TAF1;TAF11;TAF9B;TAF15;ERCC2;GTF2H4;GTF2H3-2;CCNH;TAF1L
Transcriptional misregulation in cancer	IL3;PAX3;ETV6;HIST1H3G;MAX;HOXA11;PDGFA;DDX5;PLAU

TAF15 has several biochemical functions, for example, DNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF15 itself. We selected most functions TAF15 had, and list some proteins which have the same functions with TAF15. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	SCML2;CDC5L;SIM2;ZBTB8B;ZNF71;PHC2;HOXA2B;TCF7L1A;C19orf40
nucleotide binding	UPF3A;RABL6;RAB5AA;MCM6L;YTHDC2;CELF1;GC3;MSI2;HNRNPA1L2
poly(A) RNA binding	GTF2F1;MRPL15;EIF2S2;FASTKD1;PEG10;AKAP1;MRPS28;HNRNPH1;ILF2
protein binding	ALDOB;LIN28A;B2M;PITPNC1;ACPL2;RNF146;PSMA4;STAMBP;SCAMP2
zinc ion binding	TRIM14;MMEL1;ZNF146;ZFP259;TRAF6;SIAH2L;PAM;CNBPA;CAHZ

TAF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF15.

FUS; fus_ddit3; PLEC; Taf15; CACNA1A; avtA2; sSL2; menB; q81xx8_bacan; q8d1p4_yerpe; pre-let-7a