TBX3

  • Official Full Name

    T-box 3

  • Overview

    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.
  • Synonyms

    TBX3; T-box 3; ulnar mammary syndrome , UMS; T-box transcription factor TBX3; TBX3 ISO; XHL; T-box protein 3; bladder cancer related protein XHL; UMS; TBX3-ISO;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TBX3-3143H Recombinant Human TBX3, GST-tagged E.coli GST 1-350aa
Human TBX3-29459TH Recombinant Human TBX3 Wheat Germ N/A 100 amino acids
Human TBX3-1199HCL Recombinant Human TBX3 293 Cell Lysate HEK293 N/A
Human TBX3-4445H Recombinant Human TBX3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TBX3-4867H Recombinant Human TBX3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TBX3-5125H Recombinant Human TBX3 Protein (Leu107-Thr220), His tagged E.coli His Leu107-Thr220
Human TBX3-1586H Recombinant Human TBX3 protein, His-tagged E.coli His Leu107~Thr220 (Accession # O15119)
Mouse TBX3-16532M Recombinant Mouse TBX3 Protein Mammalian Cell His
Mouse Tbx3-1587M Recombinant Mouse Tbx3 protein, His-tagged E.coli His Leu107~Thr220 (Accession # P70324)
Mouse Tbx3-6322M Recombinant Mouse Tbx3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TBX3-9061M Recombinant Mouse TBX3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TBX3-9061M-B Recombinant Mouse TBX3 Protein Pre-coupled Magnetic Beads HEK293
Rat TBX3-5975R Recombinant Rat TBX3 Protein Mammalian Cell His
Rat TBX3-5634R Recombinant Rat TBX3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TBX3-5634R-B Recombinant Rat TBX3 Protein Pre-coupled Magnetic Beads HEK293
Rat Tbx3-1588R Recombinant Rat Tbx3 protein, His-tagged E.coli His Leu107~Thr220 (Accession # Q7TST9)
Chicken TBX3-4655C Recombinant Chicken TBX3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TBX3 Related Research Area

TBX3 involved in several pathways and played different roles in them. We selected most pathways TBX3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsWNT5A;OTX1;PIK3R1;WNT5B;LEFTY2;WNT7A;HRAS;WNT2;AKT2

TBX3 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX3 itself. We selected most functions TBX3 had, and list some proteins which have the same functions with TBX3. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II activating transcription factor bindingT;EOMES;RB1;CTNNB1;CREB1;NCOR1;IFI27;NEUROD1;LMO2
RNA polymerase II core promoter proximal region sequence-specific DNA bindingSIX5;TCF7L2;CTCFL;EBF1;GLI2;NRF1;LEF1;RAX;PLAG1
RNA polymerase II transcription factor bindingWWP2;GSC;GATA5;TRPS1;SPI1;ID4;MIXL1;TAL1;TOX2
protein bindingGGPS1;NPL;TXNRD1;CDX1;NEDD4;LANCL2;ACTN3;EXO1;SIX4
sequence-specific DNA bindingSALL3B;HOXD4;KLF5;CHES1;NR1D2B;ZC3H8;DLX2B;PAX7B;HEY2
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingZGPAT;HES1;ZFP536;HAND1;SKIL;SP3;HHEX;NFIL3-6;BCL11A

TBX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX3.

CA8; AES; Dlg4; TOLLIP

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