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TBX5

  • Official Full Name

    T-box 5

  • Overview

    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the;T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is;closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein;may play a role in heart development and specification of limb identity. Mutations in this gene have been associated;with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants;encoding different isoforms have been described for this gene.
  • Synonyms

    TBX5; T-box 5; HOS; T-box transcription factor TBX5; Holt Oram syndrome; T box 5; T box protein 5; T box transcription factor TBX 5; T box transcription factor TBX5; T-box protein 5; TBX 5; TBX5_HUMAN; Transcription factor T box 5; OTTHUMP00000232132; OTTHUMP00000232133; OTTHUMP00000232134; OTTHUMP00000232135;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TBX5-3145H Recombinant Human TBX5, GST-tagged E.coli GST N-term-328aa
Human TBX5-29460TH Recombinant Human TBX5 Wheat Germ N/A 117 amino acids
Human TBX5-1198HCL Recombinant Human TBX5 293 Cell Lysate HEK293 N/A
Human TBX5-2164H Recombinant Human TBX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TBX5-5274H Recombinant Human TBX5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TBX5-2164H-B Recombinant Human TBX5 Protein Pre-coupled Magnetic Beads HEK293
Human TBX5-998HFL Recombinant Full Length Human TBX5 Protein, C-Flag-tagged Mammalian cells Flag
Human TBX5-5364H Recombinant Human TBX5 protein(1-518aa), His&Myc-tagged E.coli N-His&C-Myc 1-518aa
Mouse TBX5-16534M Recombinant Mouse TBX5 Protein Mammalian Cell His
Mouse TBX5-9063M Recombinant Mouse TBX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tbx5-6323M Recombinant Mouse Tbx5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TBX5-9063M-B Recombinant Mouse TBX5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tbx5-2116M Recombinant Mouse Tbx5 Protein, His-tagged E.coli N-His Met51-Gln251
Rat TBX5-5976R Recombinant Rat TBX5 Protein Mammalian Cell His
Rat TBX5-5635R-B Recombinant Rat TBX5 Protein Pre-coupled Magnetic Beads HEK293
Rat TBX5-5635R Recombinant Rat TBX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken TBX5-5747C Recombinant Chicken TBX5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TBX5 involved in several pathways and played different roles in them. We selected most pathways TBX5 participated on our site, such as Cardiac Progenitor Differentiation, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cardiac Progenitor DifferentiationNOG;NKX2;NIPAL1;SIRPA;LIN28B;ZFP42;T;TBX5;SOX1
Gene ExpressionD1BWG0212E;WDR4;ZNF114;IGF2BP1;Txn1;ZNF670;RORAA;ZIM3;POLR3GLA
Generic Transcription PathwayNR4A2B;ZNF317;NR1D2A;ZFP37;ZNF669;RARGA;ZKSCAN4;CCNC;MED13A
Heart DevelopmentNKX2;HEY2;FOXH1;HEY1;IRX4;TBX20;TBX5;NKX2-5;GATA6
YAP1- and WWTR1 (TAZ)-stimulated gene expressionTBX5;TBX5A;HIPK1;TEAD3B;NKX2;TEAD1A

TBX5 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX5 itself. We selected most functions TBX5 had, and list some proteins which have the same functions with TBX5. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPHTF2;ZNF703;HER6;NEUROG1;MYNN;CREB3;HIST3H2BB;MAFGA;ZFP523
RNA polymerase II regulatory region sequence-specific DNA bindingHOXD9;STAT4;CREB3L3;ESRRG;ZNF792;ZFAT;GATA2A;TAL2;TAL1
protein bindingTOMM70A;TXNDC5;LILRB4;CHRNB2;PLK2;NAT10;TKT;EEF1A2;CAB39L
sequence-specific DNA bindingRXRGA;ELK4;EOMES;FOXR2;NKX2-8;HOXC11A;SFPI1;DBPB;HEY2
transcription factor activity, sequence-specific DNA bindingATF6B;ZNF621;FOXO6;ZNF23;RORCB;MAFGB;TCF3;ZFP354A;TEAD2
transcription factor bindingIRF4;NCOA2;PPP1R13BA;PAX2;RPS3;E2F4;LEF1;NLRP3;IFT172
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingELF5;CREB3L4;IRF2;SOHLH2;GATA2A;NEUROD2;NR1I2;ETV5;GLIS1

TBX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX5.

YAP1; tbe_human-dna; CTNNB1; Nkx2-5; Ctnnb1; Gata4; Wwtr1

Research Area

Related articles

Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).
Sandstedt, J; Jonsson, M; et al. SSEA-4+CD34-Cells in the Adult Human Heart Show the Molecular Characteristics of a Novel Cardiomyocyte Progenitor Population. CELLS TISSUES ORGANS 199:103-116(2014).
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