Tek
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Official Full Name
TEK tyrosine kinase, endothelial
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Overview
This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation. -
Synonyms
TEK; TEK tyrosine kinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; venous malformations, multiple cutaneous and mucosal; Angiopoietin-1 receptor; EC=2.7.10.1; Tunica interna endothelial cell kinase; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p140 TEK; OTTHUMP00000021167; OTTHUMP00000227067; OTTHUMP00000227068; OTTHUMP00000227069; soluble TIE2 variant 1; soluble TIE2 variant 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Cynomolgus Monkey
- Human
- Human
- Mouse
- Rat
- Rhesus
- Zebrafish
- Baculovirus-Infected Sf9 Cells
- CHO
- E.coli
- HEK293
- Human Cell
- Insect Cell
- Insect cells
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Fc
- Flag
- GST
- His
- Avi
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Tek involved in several pathways and played different roles in them. We selected most pathways Tek participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tek were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | BRAP;SHC3;GNB1;CALM1;PIK3CG;PRKCG;MRAS;MAPK9;NFKB1 |
| Rap signaling pathway | CALM2;FGF5;VASP;PRKD2;ITGB3;FPR1;PRKD1;VAV2;ITGA2B |
| HIF- signaling pathway | PDK1;TLR4;GAPDH;PIK3CA;PRKCA;CAMK2G;ENO2;HKDC1;RELA |
| PIK-Akt signaling pathway | ITGA5;ITGB5;GNG8;HGF;ITGA7;LPAR4;VEGFB;CREB3L3;ITGA8 |
| Rheumatoid arthritis | CXCL1;TNFSF13;HLA-DPB1;ATP6V1E2;IL18;HLA-DOB;CTLA4;ATP6V1H;Il23a |
Tek has several biochemical functions, for example, ATP binding, growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tek itself. We selected most functions Tek had, and list some proteins which have the same functions with Tek. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CBWD2;SMYHC3;FASTK;KIF9;CCT6B;ABCF2A;PLK2B;PET112L;EPB42 |
| growth factor binding | LTBP4;ACVR2A;FGFBP2;NKD2;NRP2;REG3B;RHBDF1;A2M;IL6ST |
| protein binding | NFKBIB;SYNJ2;PPARG;ARHGEF40;TUBA4A;HPX;NCK1;SMC4;INTS4 |
| protein kinase activity | PKDCC;AURKA;MAP4K6;CSF1RA;PLK2B;CDK5;GSG2;FYNA;PTK6B |
| protein tyrosine kinase activity | YES1;MAP2K1;PDGFRB;PTK2AB;KIT;ABL2;INSRB;FER;EGFR |
| receptor activity | SELS;CD5;TNFRSF13B;BTLA;ADCYAP1R1;P2RY11;CD200R4;NLGN4X;ADIPOR2 |
| transmembrane receptor protein tyrosine kinase activity | EPHA2A;ROS1;NTRK3;ERBB4A;LTK;FGFR1A;MUSK;TIE1;ERBB3A |
Tek has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tek here. Most of them are supplied by our site. Hope this information will be useful for your research of Tek.
ANGPT2; SHC1; Angpt2; PTPRC; PKM; PTPRB; PTPRG; PTPN12; PTPRJ; PTPRK
Research Area
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Customer Reviews (3)
Write a reviewOutstanding service! Staff expertise helped us choose the perfect protein.
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Q&As (5)
Ask a questionThe TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.
The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.
The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.
The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.
The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.
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