Recombinant Rhesus TEK Protein (Met1-Lys745), His-tagged
Cat.No. : | TEK-996R |
Product Overview : | Recombinant Rhesus TEK Protein (XP_001105270.1) (Met1-Lys745) was produced by HEK293 Cells expression system. This protein was expressed with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
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Description : | TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature. |
Source : | HEK293 |
Species : | Rhesus |
Tag : | His |
Predicted N Terminal : | Ala 23 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant rhesus TEK consists of 756 amino acids and predicts a molecular mass of 84.2 kDa. |
Protein length : | Met1-Lys745 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Shipping : | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | TEK TEK receptor tyrosine kinase [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | TEK |
Gene ID : | 707455 |
mRNA Refseq : | XM_001105270 |
Protein Refseq : | XP_001105270 |
UniProt ID : | G7NFP9 |
Products Types
◆ Recombinant Protein | ||
TEK-2758H | Recombinant Human TEK Protein, His-tagged | +Inquiry |
TEK-008H | Active Recombinant Human TEK Protein, hIgG/His-tagged | +Inquiry |
TEK-036H | Active Recombinant Human TEK Protein, hIgG/His-tagged | +Inquiry |
TEK-2054H | Recombinant Human TEK Protein, Fc/His-tagged | +Inquiry |
tek-1257Z | Recombinant Zebrafish tek Protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
TEK-415HCL | Recombinant Human TEK cell lysate | +Inquiry |
TEK-404MCL | Recombinant Mouse TEK cell lysate | +Inquiry |
TEK-1707RCL | Recombinant Rat TEK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe TEK gene is crucial for vascular development during embryogenesis, coordinating with other genes and signaling pathways to ensure proper formation of the vascular system.
The TEK gene is implicated in pathological angiogenesis in diseases like cancer, where dysregulation of TIE2 signaling can contribute to aberrant blood vessel formation.
The TEK gene, through TIE2 signaling, regulates vascular permeability by influencing the integrity of endothelial cell junctions and controlling the passage of molecules across blood vessels.
The TEK gene contributes to the maintenance of vascular quiescence by suppressing endothelial cell activation and inflammation, preserving the stability of blood vessels.
The TEK gene, through TIE2 signaling, influences immune responses by modulating interactions between endothelial cells and immune cells during vascular inflammation.
Customer Reviews (3)
Write a reviewOutstanding service! Staff expertise helped us choose the perfect protein.
Seamless delivery process—ordered, received, and ready for experiments.
Courteous and efficient customer service made our purchase hassle-free.
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