TET2

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TET2

Official Full Name tet methylcytosine dioxygenase 2
Background The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
Synonyms TET2; tet methylcytosine dioxygenase 2; KIAA1546 , tet oncogene family member 2; methylcytosine dioxygenase TET2; FLJ20032; tet oncogene family member 2; probable methylcytosine dioxygenase TET2; MDS; KIAA1546; MGC125715
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • FLAG/His
    • GST
    • His
    • KSI
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TET2-311H Recombinant Human TET2 protein, His-tagged E. coli His
    Human TET2-01H Recombinant Human TET2 Protein, FLAG/His-tagged Insect Cell FLAG/His
    Human TET2-160H Recombinant Human TET2, GST-tagged Sf9 Insect Cell GST
    Human TET2-3184H Recombinant Human TET2, His-tagged E. coli His
    Mouse TET2-16653M Recombinant Mouse TET2 Protein Mammalian Cell His
    Mouse TET2-2683M Recombinant Mouse TET2 Protein (1810-1912 aa), His-KSI-tagged E.coli His/KSI
    Chicken TET2-5153C Recombinant Chicken TET2 Mammalian Cell His

    TET2 involved in several pathways and played different roles in them. We selected most pathways TET2 participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, TET1,2,3 and TDG demethylate DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with TET2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epigenetic regulation of gene expression TET2; SUZ12A; BAZ2A; AEBP2; JARID2B; TAF1D; MTF2; TET3; TAF1C; PHF1
    Gene Expression PRMT5; GTF3C3; ZFP2; TYW5; DNMT1; NR2C2; SUPT16H; PRDM7; NRBF2B; TEAD3B
    TET1,2,3 and TDG demethylate DNA TET1; TET2; TET3

    TET2 has several biochemical functions, for example, DNA binding, ferrous iron binding, methylcytosine dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TET2 itself. We selected most functions TET2 had, and list some proteins which have the same functions with TET2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding FOXO3B; ZFP653; POU3F3; LMX1BA; TBX24; HIST2H2BB; ZFP143; EMX3; CHD2; POU4F1
    ferrous iron binding ISCA1; DNAJC24; SNCA; TET2; NT5E; FECH; ISCU; HAAO; EGLN2; ALKBH3
    methylcytosine dioxygenase activity TET3; TET2; ALKBH1; TET1
    protein binding TAOK3; NECAB2; C9orf116; PRKD3; MMP2; FIG4; SIRPB1; TREML2; ABCC2; ZNF131
    zinc ion binding MAN2C1; APOBEC1; EEA1; GCM1; KIAA0913; AKT1S1; CPSF4; ADAM21; RFPL4; RNF183

    TET2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TET2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TET2.

    OGT; HCFC1; TBC1D4; brnQ3; YWHAQ; SMARCA4; YWHAG; YWHAH; SMARCC2

    Aoki, Y; Watanabe, T; et al. Identification of CD34(+) and CD34(-) leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia. BLOOD 125:967-980(2015).
    Ahearne, MJ; Allchin, RL; et al. Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment. BRITISH JOURNAL OF HAEMATOLOGY 166:326-335(2014).

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