|Official Full Name||tet methylcytosine dioxygenase 2|
|Background||The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.|
|Synonyms||TET2; tet methylcytosine dioxygenase 2; KIAA1546 , tet oncogene family member 2; methylcytosine dioxygenase TET2; FLJ20032; tet oncogene family member 2; probable methylcytosine dioxygenase TET2; MDS; KIAA1546; MGC125715|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TET2 involved in several pathways and played different roles in them. We selected most pathways TET2 participated on our site, such as Epigenetic regulation of gene expression, Gene Expression, TET1,2,3 and TDG demethylate DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with TET2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Epigenetic regulation of gene expression||TET2; SUZ12A; BAZ2A; AEBP2; JARID2B; TAF1D; MTF2; TET3; TAF1C; PHF1|
|Gene Expression||PRMT5; GTF3C3; ZFP2; TYW5; DNMT1; NR2C2; SUPT16H; PRDM7; NRBF2B; TEAD3B|
|TET1,2,3 and TDG demethylate DNA||TET1; TET2; TET3|
TET2 has several biochemical functions, for example, DNA binding, ferrous iron binding, methylcytosine dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TET2 itself. We selected most functions TET2 had, and list some proteins which have the same functions with TET2. You can find most of the proteins on our site.
|DNA binding||FOXO3B; ZFP653; POU3F3; LMX1BA; TBX24; HIST2H2BB; ZFP143; EMX3; CHD2; POU4F1|
|ferrous iron binding||ISCA1; DNAJC24; SNCA; TET2; NT5E; FECH; ISCU; HAAO; EGLN2; ALKBH3|
|methylcytosine dioxygenase activity||TET3; TET2; ALKBH1; TET1|
|protein binding||TAOK3; NECAB2; C9orf116; PRKD3; MMP2; FIG4; SIRPB1; TREML2; ABCC2; ZNF131|
|zinc ion binding||MAN2C1; APOBEC1; EEA1; GCM1; KIAA0913; AKT1S1; CPSF4; ADAM21; RFPL4; RNF183|
TET2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TET2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TET2.
OGT; HCFC1; TBC1D4; brnQ3; YWHAQ; SMARCA4; YWHAG; YWHAH; SMARCC2