THBS4
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Official Full Name
thrombospondin 4
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Overview
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system. -
Synonyms
THBS4; thrombospondin 4; thrombospondin-4; TSP4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- His|GST
- N/A
- N
- T7|His
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | THBS4-507H | Active Recombinant Human Thrombospondin 4, His-tagged | CHO | His |
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| Human | THBS4-8256H | Recombinant Human THBS4 protein, His & GST-tagged | E.coli | His/GST | Pro644~Cys925 (Accession # P35443) |
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| Human | THBS4-121H | Recombinant Human THBS4, GST-tagged | Wheat Germ | GST | ||
| Human | THBS4-114H | Recombinant Human THBS4 protein, T7/His-tagged | E.coli | T7/His |
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| Human | THBS4-1774HCL | Recombinant Human THBS4 cell lysate | N/A |
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| Human | THBS4-6447H | Recombinant Human THBS4 Protein (Pro644-Leu866), N-GST tagged | E.coli | N-GST | Pro644-Leu866 |
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| Human | THBS4-523HF | Recombinant Full Length Human THBS4 Protein, GST-tagged | In Vitro Cell Free System | GST | 961 amino acids |
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| Mouse | Thbs4-120M | Active Recombinant Mouse Thbs4, His-tagged | CHO | His |
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| Mouse | Thbs4-8257M | Recombinant Mouse Thbs4 protein, His & GST-tagged | E.coli | His/GST | Gly662~Leu923 (Accession # Q9Z1T2) |
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| Mouse | Thbs4-05M | Recombinant Mouse Thbs4 Protein, His-tagged | HEK293 | His | 27-963 |
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| Mouse | Thbs4-2132M | Recombinant Mouse Thbs4 Protein, His-tagged | E.coli | N-His | Gly662-Leu923 |
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| Rat | Thbs4-8258R | Recombinant Rat Thbs4 protein, His & GST-tagged | E.coli | His/GST | Pro708~Ile963 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- THBS4 Related Research Area
- THBS4 Related Signal Pathway
THBS4 involved in several pathways and played different roles in them. We selected most pathways THBS4 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | SEC61AL2;BLB2;C1RA;ACTB1;ATP6V0A2B;STX18;NOS1;Cd209g;TLR4BB |
| PIK-Akt signaling pathway | GNG11;FLT4;Fgf15;PIK3R5;IFNA16;IKBKB;Il2;TSC2;EPOR |
| Focal adhesion | COL11A1A;PRKCBB;FLNA;HRASA;ZYX;PPP1R12C;RAPGEF1B;CAPN2B;DIAPH1 |
| ECM-receptor interaction | Itga10&Itgb1;COL4A5;COL4A3;LAMC2;COL27A1B;Reln;GP9;LAMB1;COL5A2 |
| Malaria | Ccl12;MYD88;IL12A;CD36;TLR4;PECAM1;TGFB1;IL-8;ITGB2L |
THBS4 has several biochemical functions, for example, calcium ion binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS4 itself. We selected most functions THBS4 had, and list some proteins which have the same functions with THBS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH2AB5;SLC25A13;RCVRN;PADI1;NCAN;DSC2L;CRB1;PCDH17;DSG2 |
| growth factor activity | INHBAA;IGF1;Il2;GDF5;NTF7;FGF20A;GDF15;FGF3;TDGF1 |
| heparin binding | FGFBP3;LXN;BSPH1;APOA5;NRP1;MMP7;SMOC2;FSTL1;GREM2 |
| integrin binding | DST;ADAM2;GFAP;ECM2;ESM1;ICAM4;WISP1;LAMB1;ITGB1BP2 |
| protein binding | CYP1A1;USP46;PKD2;SEMA6A;MUSK;COBRA1;ZCCHC12;UBA52;TTC3 |
THBS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS4.
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