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THBS4

Official Full Name

thrombospondin 4
Overview

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.
Synonyms

THBS4; thrombospondin 4; thrombospondin-4; TSP4;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Rat

Source

CHO
E.coli
HEK293
In Vitro Cell Free System
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	THBS4-507H	Active Recombinant Human Thrombospondin 4, His-tagged	CHO	His	Ala22-Asn961	Inquiry
Human	THBS4-8256H	Recombinant Human THBS4 protein, His & GST-tagged	E.coli	His&GST	Pro644~Cys925	Inquiry
Human	THBS4-121H	Recombinant Human THBS4, GST-tagged	Wheat Germ	GST		$279 / 2μg
Human	THBS4-114H	Recombinant Human THBS4 protein, T7/His-tagged	E.coli	His&T7	27-961	Inquiry
Human	THBS4-1774HCL	Recombinant Human THBS4 cell lysate		Non		Inquiry
Human	THBS4-6447H	Recombinant Human THBS4 Protein (Pro644-Leu866), N-GST tagged	E.coli	GST	Pro644-Leu866	Inquiry
Human	THBS4-523HF	Recombinant Full Length Human THBS4 Protein, GST-tagged	In Vitro Cell Free System	GST	961 amino acids	Inquiry
Mouse	Thbs4-120M	Active Recombinant Mouse Thbs4, His-tagged	CHO	His	Gln27-Asn963	Inquiry
Mouse	Thbs4-8257M	Recombinant Mouse Thbs4 protein, His & GST-tagged	E.coli	His&GST	Gly662~Leu923	Inquiry
Mouse	Thbs4-05M	Recombinant Mouse Thbs4 Protein, His-tagged	HEK293	His	27-963	Inquiry
Mouse	Thbs4-2132M	Recombinant Mouse Thbs4 Protein, His-tagged	E.coli	His	Gly662-Leu923	Inquiry
Rat	Thbs4-8258R	Recombinant Rat Thbs4 protein, His & GST-tagged	E.coli	His&GST	Pro708~Ile963	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
THBS4 Related Signal Pathway

THBS4 involved in several pathways and played different roles in them. We selected most pathways THBS4 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	TUBA1B;C1R;BMA1;TLR4BB;ATP6V1F;SEC22B;CCDC102A;H2-AA;H2-Q10
PIK-Akt signaling pathway	CCND1;TNXB;CCND3;LAMA4;FGF6;FGF19;PIK3CD;FGF17;LAMA5
Focal adhesion	VEGFAB;Pdgfa&Pdgfb;COL6A2;PRKCG;FLNB;BADB;ITGA7;ROCK2A;MAP2K1
ECM-receptor interaction	COL5A1;CHAD;LAMB1A;ITGA11A;THBS2;IBSP;COL6A6;ITGB3;COL6A5
Malaria	ITGB2;SELE;CD36;LRP1;THBS4;TLR4;IL12A;HBB;IFNG

THBS4 has several biochemical functions, for example, calcium ion binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THBS4 itself. We selected most functions THBS4 had, and list some proteins which have the same functions with THBS4. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	EFEMP1;PCDH1G1;BNIP2;CDH7;CELSR3;CHP;ACTN2;PROZ;JAG1
growth factor activity	GDF2;PTN;PDGFAB;TGFB3;MDKA;PDGFC;BMP1;BMP7A;FGF18B
heparin binding	PGF;FGFBP1;PCOLCE;CCL7;CECR1;LXN;SELL;MSTN;THBS1
integrin binding	ADAMTS8;LAMA5;P4HB;LYN;FAP;CD226;WISP2;CALR;NOV
protein binding	ATRX;FERMT2;ATF7IP;DCDC2;ZYX;CUL4A;UBE2V2;COPS7A;MED19

THBS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THBS4.

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