Recombinant Mouse Thbs4 Protein, His-tagged

• Cat.No.: Thbs4-05M
• Product Overview: Recombinant mouse Thrombospondin-4, fused to His-tag at C terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Specification

• Description: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner.
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Liquid
• Molecular Mass: 104.3 kDa (943aa)
• Protein length: 27-963
• AA Sequence: QATPQVFDLLPSSSQRLNPSALQPV LTDPTLHEVYLISTFKLQSKSSATI FGLYSSSDNSKYFEFTVMGRLNKAI LRYLKNDGKIHLVVFNNLQLADGRR HRVLLRLSNLQRGDGSVELYLDCAQ ADSVRNLPRAFSGLTQNPESIELRT FQRKPQDFLEELKLVVRGSLFQVAS LQDCFLQQSEPLAATSTGDFNRQFL GQMTQLNQLLGEVKDLLRQQVKETS FLRNTIAECQACGPLSFQSPTPNTL VPIAPPAPPTRPTRHCDSSPCFRGV RCTDTRDGFQCGPCPDGYTGNGITC SDVDECKYHPCYPGVRCVNLAPGFR CDACPVGFTGPMVQGVGINFAKTNK QVCTDVDECQNGACVLNSICINTLG SYRCGPCKPGYTGDQTRGCKTERSC RNPEQNPCSVHAQCIEERQGDVTCV CGVGWAGDGYVCGKDVDIDSYPDEE LPCSARNCKKDNCKYVPNSGQEDAD RDGIGDACDEDADGDGILNEQDNCV LTHNIDQRNSDKDIFGDACDNCRMV LNNDQKDTDGDGRGDACDDDMDGDG IKNILDNCPRVPNRDQQDRDGDDVG DACDSCPDVSNPNQSDVDNDLVGDS CDTNQDSDGDGHQDSTDNCPTVINS SQLDTDKDGIGDECDDDDDNDGIPD LVPPGPDNCRLVPNPAQEDSNNDGV GDICEADFDQDQVIDHIDVCPENAE ITLTDFRAYQTVVLDPEGDAQIDPN WVVLNQGMEIVQTMNSDPGLAVGYT AFNGVDFEGTFHVNTQTDDDYAGFI FGYQDSSSFYVVMWKQTEQTYWQAT PFRAVAEPGIQLKAVKSKTGPGEHL RNSLWHTGDTSDQVRLLWKDSRNVG WKDKVSYRWFLQHRPQVGYIRVRFY EGSELVADSGVTIDTTMRGGRLGVF CFSQENIIWSNLKYRCNDTIPEDFQ EFQTQSFDRLDN
• Endotoxin: < 1 EU/μg of protein (determined by LAL method)
• Purity: > 85 % by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/mL
• Storage Buffer: PBS (pH 7.4) containing 0.1mM PMSF, 20% glycerol

Gene Information

• Gene Name: Thbs4 thrombospondin 4 [ Mus musculus (house mouse) ]
• Official Symbol: Thbs4
• Synonyms: Thbs4; thrombospondin 4; TS; TSP; TSP4; thrombospondin-4
• Gene ID: 21828
• mRNA Refseq: NM_011582
• Protein Refseq: NP_035712
• UniProt ID: Q9Z1T2