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TLE2

  • Official Full Name

    transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)

  • Overview

    Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.
  • Synonyms

    TLE2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin like enhancer of split 2, homolog of Drosophila E(sp1); transducin-like enhancer protein 2; enhancer of split groucho 2; ESG; ESG2; FLJ41188; GRG2; Enhancer of split groucho-like protein 2; Groucho2; KIAA4188; MGC124808; mKIAA4188; Tle2 protein; TLE2_HUMAN; transducin like enhancer of split 2; Transducin like enhancer protein 2; Transducin-like enhancer of split 2, homolog of Drosophila E(spl); transducin-like enhancer of split 2, homolog of Drosophila E(sp1);
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLE2-1050HCL Recombinant Human TLE2 293 Cell Lysate HEK293 N/A
Human TLE2-1209H Recombinant Human TLE2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Tle2-6448M Recombinant Mouse Tle2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish TLE2-7087Z Recombinant Zebrafish TLE2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TLE2 involved in several pathways and played different roles in them. We selected most pathways TLE2 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Deactivation of the beta-catenin transactivating complexTLE2;SOX9A;TLE4;SOX13;PYGO1;SRY;TLE3;SOX4A;SOX7
Degradation of beta-catenin by the destruction complexAES;CTBP1;CTBP2;TLE2;TLE4;FAM123B;TLE1;TLE3;TLE3B
Formation of the beta-catenin:TCF transactivating complexTLE3;H3F3B.1;RBBP5;BCL9;CDC73;TLE2;H3F3D;ASH2L;TLE4
NOTCH1 Intracellular Domain Regulates TranscriptionTLE2;HEYL;HEY2;TUBB3;HEY1;TLE3;TLE1;TLE4
Regulation of Wnt-mediated beta catenin signaling and target gene transcriptionCYR61;CDX4;TLE1;SALL4;IGF2BP1;CBY1;MYOG;T;TLE2
Repression of WNT target genesTLE3B;TLE4;TLE3;AES;TLE2
Signal TransductionRIT1;CSNK1G2;FAM13B;OR4D2;GPR120;FGD4A;SHARPIN;FMNL3;ARHGAP25
Signaling by NOTCHTLE4;DTX2;MDKA;MDKB;HEYL;TLE3;DNER;MDK;DLK1

TLE2 has several biochemical functions, for example, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE2 itself. We selected most functions TLE2 had, and list some proteins which have the same functions with TLE2. You can find most of the proteins on our site.

Function Related Protein
protein bindingMT1G;DAZAP2;VCL;PRAME;MUL1;SKP2;RTKN;DHX32;GCKR
transcription corepressor activitySIRT1;HDAC3;ZMYND11;ZHX3;TBL1Y;GPS2;HDAC4;ZHX2;NSD1

TLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE2.

DDB1; NUDC; CUL4B

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