TLR9
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Official Full Name
toll-like receptor 9
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Overview
Toll-like receptor 9 is a protein that in humans is encoded by the TLR9 gene. TLR9 has also been designated as CD289 (cluster of differentiation 289). -
Synonyms
CD 289; CD289; TLR 9; TLR9; TLR9_HUMAN; Toll like receptor 9; Toll like receptor 9 isoform A precursor; Toll like receptor 9 isoform B; Toll-like receptor 9; CD289 antigen;
- Recombinant Proteins
- Cell & Tissue Lysates
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- Mammalian cells
- Wheat Germ
- Fc
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- His
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- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
TLR9 involved in several pathways and played different roles in them. We selected most pathways TLR9 participated on our site, such as Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Toll-like receptor signaling pathway | MAPK13;IFNAR1;MAPK12;RELA;MAPK14B;MAPK3;PIK3CD;IFNB;MAPK10 |
| Chagas disease (American trypanosomiasis) | AKT1;PPP2R2C;Il2;PIK3R1;MAPK9;GNAI1;C1QC;TGFB3;GNA14 |
| African trypanosomiasis | PRKCA;LAMA4;IL12A;PLCB2;HBB-B2;VCAM1;TNF;HPR;IDO2 |
| Malaria | MET;THBS3;SDC1;IL6;ITGB2;IL12A;SDC2;GYPC;CSF3 |
| Tuberculosis | EP300;MAPK11;HLA-DOA;HLA-DQA1;RFXAP;TLR2;BCL2;IFNA1;KSR1 |
| Measles | IFNB1;OAS3;DOK1;IL1B;IFNGR2;IFNA21;EIF2AK1;IFNA6;SLAMF1 |
| Herpes simplex infection | HNRPKL;SRSF7B;EIF2AK3;SRSF1A;PPP1CBL;TLR3;USP7;MAPK9;TTC6 |
TLR9 has several biochemical functions, for example, interleukin-1 receptor binding, siRNA binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR9 itself. We selected most functions TLR9 had, and list some proteins which have the same functions with TLR9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-1 receptor binding | IL1B;IL36A;Il1f6;TLR9;IL1RAP;IRAK1;IL36G;IL1RN;IL1F10 |
| siRNA binding | TARBP2;AGO2;MECP2;TLR7;TLR9;DICER1 |
| transmembrane signaling receptor activity | FZD9B;CELSR1;FZD3B;KLRC3;CLEC2D;NPR2;FCGR2C;MPL;OR12D2 |
TLR9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR9 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR9.
NCK1; CLGN; TRAF3; STK11IP; TOLLIP; UNC93B1; UGGT1; PALD1
Research Area
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Q&As (7)
Ask a questionTLR9 is primarily located in endosomes and lysosomes.
TLR9 detects unmethylated CpG DNA from bacteria and viruses, activating immune responses.
Therapeutic strategies may target TLR9 to enhance vaccine efficacy or modulate autoimmune responses.
Dysregulation of TLR9 can contribute to the development of autoimmune diseases.
It recognizes foreign DNA based on specific nucleotide patterns, initiating signaling cascades.
It plays a role in defending against bacterial and viral infections.
TLR9 activation leads to NF-κB activation and cytokine production.
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