TRIB3
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Official Full Name
tribbles pseudokinase 3
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Overview
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq, Jul 2008] -
Synonyms
TRIB3; tribbles pseudokinase 3; NIPK; SINK; TRB3; SKIP3; C20orf97; tribbles homolog 3; TRB-3; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; neuronal cell death inducible putative kinase; neuronal cell death-inducible putative kinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- No tag
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TRIB3-25H | Recombinant Human TRIB3, GST-tagged | Sf9 Insect Cell | GST |
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| Human | TRIB3-30123TH | Recombinant Human TRIB3 | Wheat Germ | N/A | 358 amino acids |
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| Human | TRIB3-3073H | Recombinant Human TRIB3 protein(Met1-Gly358), GST-tagged | Insect Cells | N-GST | Met1-Gly358 | |
| Human | TRIB3-657HCL | Recombinant Human TRIB3 cell lysate | Insect Cell | N/A |
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| Human | TRIB3-301436H | Recombinant Human TRIB3 protein, GST-tagged | E.coli | GST | Met1-Met144 |
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| Human | TRIB3-0563H | Recombinant Human TRIB3 Protein (R2-G358), His/GST tagged | Insect Cell | His/GST | R2-G358 |
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| Human | TRIB3-0564H | Recombinant Human TRIB3 Protein (R2-G358), Tag Free | Insect Cell | No tag | R2-G358 |
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| Human | TRIB3-536HF | Recombinant Full Length Human TRIB3 Protein | In Vitro Cell Free System | 358 amino acids |
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| Human | TRIB3-3114H | Recombinant Human TRIB3 protein, His-tagged | E.coli | His | 1-144 aa | |
| Rat | TRIB3-6268R | Recombinant Rat TRIB3 Protein | Mammalian Cell | His |
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| Rat | TRIB3-5925R | Recombinant Rat TRIB3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | TRIB3-5925R-B | Recombinant Rat TRIB3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | TRIB3-12130Z | Recombinant Zebrafish TRIB3 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- TRIB3 Related Articles
TRIB3 involved in several pathways and played different roles in them. We selected most pathways TRIB3 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PPARGC1B;PPP1CAA;CD36;AKT2;PPP1R3CA;RPS6KA3;PRKAG2;GSK3AA;PDPK1B |
TRIB3 has several biochemical functions, for example, ATP binding, NOT kinase activity, mitogen-activated protein kinase kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIB3 itself. We selected most functions TRIB3 had, and list some proteins which have the same functions with TRIB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MCM9;EHD3;PAPSS1;DNAJA1;PRKCBA;ULK3;CDC42BPB;JAK1;HSPA4B |
| NOT kinase activity | TRIB3;SCYL3 |
| mitogen-activated protein kinase kinase binding | RAF1;TAOK2;MAPK8IP3;ACE;PIN1;TRIB2;MAP3K11;TRIB3;IGBP1 |
| protein binding | ARHGEF38;CCDC92;HSPA1B;PURA;GCKR;NAA16;BDKRB2;PRCP;TUBB2B |
| protein kinase binding | EEF1A2;TP53;MAVS;NR4A3;BCL2L1;PRKAG3;PIH1D1;TCTN2;CEP68 |
| protein kinase inhibitor activity | SOCS3A;JIP1;MBIP;WNK1;SOCS1;TRIB1;CD36;TESC;SOCS5B |
| transcription corepressor activity | NR0B2;ELK3;NAB2;TRIM28;CBX4;LOXL2;SKI;BHLHE40;TBL1XR1 |
| ubiquitin protein ligase binding | SMAD7;POU5F1;NLK;PRKAR2B;TRIB2;PER1;BLZF1;UBXN6;PIAS4 |
| ubiquitin-protein transferase regulator activity | TRIB3;TRIB1;TRIB2 |
TRIB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIB3.
ATF4; ATF4; RPGRIP1; PRMT5; MAP2K7; MAP2K1; GDF9; EEF1G; SETDB1; RBM48
- Q&As
- Reviews
Q&As (5)
Ask a questionTRIB3 has been implicated in promoting cancer cell proliferation, survival, and metastasis in various types of cancer.
Targeting TRIB3 may have implications for the treatment of cardiovascular diseases, including atherosclerosis.
TRIB3 has been shown to regulate insulin signaling and glucose metabolism, and its overexpression has been linked to insulin resistance and type 2 diabetes.
Yes, targeting TRIB3 may be a potential strategy for inhibiting cancer cell growth and metastasis.
TRIB3 has been implicated in several diseases, including diabetes, cancer, and cardiovascular diseases.
Customer Reviews (3)
Write a reviewThe manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.
Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the TRIB3 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.
They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the TRIB3 protein.
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