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TSC2

Official Full Name

tuberous sclerosis 2
Overview

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms

TSC2; tuberous sclerosis 2; LAM; TSC4; tuberin; tuberous sclerosis 2 protein;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TSC2-31631TH	Recombinant Human TSC2, His-tagged	E.coli	His		Inquiry
Human	TSC2-35H	Recombinant Human TSC2 protein, His-tagged	E.coli	His	1459-1807 aa	$319 / 25μg
Rat	TSC2-6310R	Recombinant Rat TSC2 Protein	Mammalian Cell	His		Inquiry
Rat	TSC2-5967R-B	Recombinant Rat TSC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	TSC2-5967R	Recombinant Rat TSC2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Zebrafish	TSC2-4633Z	Recombinant Zebrafish TSC2	Mammalian Cell	His		Inquiry
Zebrafish	TSC2-6386Z	Recombinant Zebrafish TSC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
TSC2 Related Signal Pathway

TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway, p signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phospholipase D signaling pathway	PIK3CB;PLCB2;PLCB1;MAPK3;PIK3CA;MAPK1;GRM1;MS4A2;CXCR1
p signaling pathway	RFWD2;SFN;TP53;RCHY1;SESN1;CASP3A;SIAH1A;CASP3B;RRM2
mTOR signaling pathway	PRKCB;VEGFAA;EIF4E2RS1;AKT2L;RRAGC;PRKAA1;PRKCBB;PIK3R3B;AKT1
PIK-Akt signaling pathway	FGFR3;PIK3R3;FASLG;IL7R;CCND2;IL2RB;RAC1;FIGF;SGK3
AMPK signaling pathway	AKT1S1;CCND1;Scd2;CRTC2;CAB39;G6PC2;FASN;G6PC;GYS2
Insulin signaling pathway	PRKACAA;PIK3CA;INSRA;SOCS1;FLOT1;ACACA;PIK3R3A;PRKCI;PTPN1
Thyroid hormone signaling pathway	SLC2A1;PDPK1;ATP1B4;PIK3CB;HDAC1;SLC16A10;AKT2;PRKCG;THRB
Choline metabolism in cancer	EIF4EBP1;MAP2K1;MTOR;PIP5K1A;MAP2K2;PIP5K1C;HIF1A;AKT2;SLC5A7

TSC2 has several biochemical functions, for example, 14-3-3 protein binding, GTPase activator activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.

Function	Related Protein
14-3-3 protein binding	PRKCE;PPP1R12A;HDAC7;DDIT4;PRKCZ;RPTOR;HDAC7A;YWHAQ;ARRB2
GTPase activator activity	RGS3;CDC42EP1B;ECT2;SIPA1L1;LLGL2;TBC1D10A;TBC1D1;ARHGAP19;RINL
phosphatase binding	PPP1R36;CRY2;DLG1;SH3GL1;PPP1R21;CARHSP1;ELFN1;SLC9A3R2;MAPK3
protein binding	Artn;WBP1;MKL1;MZB1;DLX4;CELF1;ITPRIPL1;GRASP;ACTA1
protein homodimerization activity	HELT;TBX1;INHBB;TREX2;BCL2A;ODZ4;ASCL1;BNIP3L;MAPK4
small GTPase binding	GDI2;PEX5L;FGD6;FGD1;FGD4;PEX5;RNF152;FGD3;FGD2

TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.

YWHAB; YWHAZ