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TSC2

  • Official Full Name

    tuberous sclerosis 2

  • Overview

    Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms

    TSC2; tuberous sclerosis 2; LAM; TSC4; tuberin; tuberous sclerosis 2 protein;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TSC2-31631TH Recombinant Human TSC2, His-tagged E.coli His
Human TSC2-35H Recombinant Human TSC2 protein, His-tagged E.coli His 1459-1807 aa
Rat TSC2-6310R Recombinant Rat TSC2 Protein Mammalian Cell His
Rat TSC2-5967R-B Recombinant Rat TSC2 Protein Pre-coupled Magnetic Beads HEK293
Rat TSC2-5967R Recombinant Rat TSC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TSC2-4633Z Recombinant Zebrafish TSC2 Mammalian Cell His
Zebrafish TSC2-6386Z Recombinant Zebrafish TSC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TSC2 Related Research Area
  • TSC2 Related Signal Pathway

TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway, p signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Phospholipase D signaling pathwayINS2;Pdgfa&Pdgfb;PIK3R2;GRM4;CXCR1;PIP5K1C;AVPR1A;PIK3R3;PTGFR
p signaling pathwayCOP1;ATM;SIAH1A;BAI1;RCHY1;CASP9;RPRMA;APAF1;CCND2A
mTOR signaling pathwayINSB;PIK3R1;MAPK1;EIF4E2RS1;VEGFAA;RRAGC;PTENB;EIF4BB;RPS6KA1
PIK-Akt signaling pathwayTCL1B4;PIK3CA;LAMA2;KITLG;ITGA3;HSP90AA1;MTOR;ITGA6;PCK2
AMPK signaling pathwayCPT1C;ACACB;RAB2A;PPARGC1A;CCND1;PRKAB1;PIK3R3;PRKAB2;CREB3L4
Insulin signaling pathwayPPARGC1A;EIF4EA;SOCS1A;PRKAR2B;PIK3CB;PRKAG2A;TRIP10;PYGM;FLOT1A
Thyroid hormone signaling pathwayKAT2B;PLCD4;WNT4;PIK3CB;PRKCB;NOTCH4;DIO3;SLC2A1;TBC1D4
Choline metabolism in cancerPLD1;WASF3;Pdgfa&Pdgfb;PRKCG;GPCPD1;PIP5K1B;SLC5A7;RAF1;TAE1

TSC2 has several biochemical functions, for example, 14-3-3 protein binding, GTPase activator activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.

Function Related Protein
14-3-3 protein bindingYWHAQ;ZFP36;PPP1R12A;TSC2;HDAC7;HDAC7A;IRS2;SRPK2;KCNH1
GTPase activator activityARHGAP15;TBC1D2;SRGAP1;IQGAP3;ARHGAP11A;NCKAP1L;ABR;TBC1D17;ARHGAP28
phosphatase bindingSLC9A3R2;CSRNP2;PPP1R32;PPP1R27;PPP1R21;CRY1;PPARA;DZIP3;SLC9A3R1
protein bindingACTL7A;ERCC1;SIX4;SSX5;EIF3E;CDC37;WLS;SF3A2;ATXN7
protein homodimerization activityALX1;CD2;ROPN1B;RABEP1;CIDEA;AP1S2;GSTM1;GRM6;ACTN1
small GTPase bindingABCA1;RCC2;TSC2;PEX5;RNF152;GDI2;FGD2;FGD1;FLNA

TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.

YWHAB; YWHAZ

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