TSC2 Protein


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Official Full Name tuberous sclerosis 2
Background Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms TSC2; tuberous sclerosis 2; LAM; TSC4; tuberin; tuberous sclerosis 2 protein;
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TSC2-31631TH Recombinant Human TSC2, His-tagged E.coli His
    Rat TSC2-6310R Recombinant Rat TSC2 Protein Mammalian Cell His
    Zebrafish TSC2-4633Z Recombinant Zebrafish TSC2 Mammalian Cell His
    Zebrafish TSC2-6386Z Recombinant Zebrafish TSC2 Mammalian Cell His
    Human TSC2-35H Recombinant Human TSC2 protein, His-tagged E.coli His

    TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway, p signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway RAF1; LPAR6; PPAP2B; PDGFB; MAPK1; RHEB; AVP; GAB2; AGPAT4; IL-8
    p signaling pathway CASP3B; CCNB3; IGF1; TP53I3; PTEN; STEAP3; PTENB; TSC2; SIAH1; THBS1
    mTOR signaling pathway PIK3R3B; PIK3R2; RPS6KB1; PRKCG; PIK3R5; RICTOR; HIF1AB; RHEB; RPS6KA2; RPS6KA3A
    PIK-Akt signaling pathway PIK3R3; ITGB4; GH1; RPTOR; GRB2; YWHAG; KRAS; Il2; GNB4; RBL2
    AMPK signaling pathway CPT1C; TSC2; LIPE; PFKFB1; CREB3L1; PPP2R2A; AKT1S1; HMGCR; RAB11B; INS1
    Insulin signaling pathway PDPK1; PIK3R3; PTPRFB; FBP1A; GSK3AA; PIK3R1; BADB; PIK3R5; PRKCZ; EIF4E2
    Thyroid hormone signaling pathway SIN3A; PLCB3; ATP1A2; SLC16A10; PDPK1; ATP1B2; FOXO1; ITGAV; PLCB2; SLCO1C1
    Choline metabolism in cancer DGKZ; PPAP2A; CHKB; MAP2K1; PCYT1A; CHKA; EGF; PLA2G4B; MAPK3; SLC22A3

    TSC2 has several biochemical functions, for example, 14-3-3 protein binding, GTPase activator activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding KIF13B; PRKCE; HDAC7; AKT1; YWHAQ; SRPK2; PPP1R12A; RPTOR; AANAT; HDAC7A
    GTPase activator activity AXIN1; SMAP2; GAPVD1; MYO9B; RGS14A; CHML; ALDH1A1; GMIP; SIPA1L2; RANGAP1A
    phosphatase binding SMAD2; SH3YL1; DYSFIP1; KLRAQ1; SPRED1; SYTL2; PPP1R27; PPARA; ELFN2; MAGI2
    protein binding MACF1; SPG21; TESC; VANGL1; PFDN2; UGGT1; AMOTL2; HTR1E; ANKHD1; CAMK2B
    protein homodimerization activity TREX1; SLC11A1; GSS; SUMF1; S100A13; TBX15; HELT; MCL1; MCL1A; SPPL3
    small GTPase binding FGD6; PEX5; FLNA; FGD1; FGD3; GDI2; ERRFI1; RNF152; ABCA1; TSC2

    TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.


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