TSC2

  • Official Full Name

    tuberous sclerosis 2
  • Overview

    Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms

    TSC2;tuberous sclerosis 2;LAM;TSC4;tuberin;tuberous sclerosis 2 protein

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
TSC2-35H Recombinant Human TSC2 protein, His-tagged E.coli Human His 1459-1807 aa
TSC2-31631TH Recombinant Human TSC2, His-tagged E.coli Human His 1396-1725 a.a.
TSC2-4633Z Recombinant Zebrafish TSC2 Mammalian Cells Zebrafish His
TSC2-6310R Recombinant Rat TSC2 Protein Mammalian Cells Rat His
TSC2-6386Z Recombinant Zebrafish TSC2 Mammalian Cells Zebrafish His
TSC2-5967R Recombinant Rat TSC2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
TSC2-5967R-B Recombinant Rat TSC2 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway,p signaling pathway,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway PIK3R1,PTGFR,TSC1,PIK3R3,PIP5K1C,AKT2,LPAR6,SHC2,HRAS,GNA12
    mTOR signaling pathway PRKCBA,TSC1B,PIK3R3A,RPS6KB2,PIK3R2,VEGFAA,RPS6KAL,MTOR,AKT1S1,PRKAA1
    Thyroid hormone signaling pathway PRKCB,PLCB4,PIK3R1,THRA,ATP1A4,PRKCG,NOTCH1,NRAS,PLCZ1,HIF1A
    AMPK signaling pathway PRKAA1,RAB8A,IRS2,PIK3CB,PFKFB3,G6PC3,PPP2R2A,ADIPOR2,ACACA,PRKAB1
    Choline metabolism in cancer TAE1,PDGFA,DGKQ,WASF2,PIK3CG,MAPK3,SOS1,PIK3CB,PDPK1,PPAP2B
    p signaling pathway GADD45BA,TP73,LRDD,RCHY1,SFN,COP1,GADD45B,GADD45AB,PPM1DB,STEAP3
    PIK-Akt signaling pathway FGF4,PPP2R2B,PCK1,FGFR2,AKT2,PIK3CG,FGF12,GSK3B,NGFR,FN1
    Insulin signaling pathway IRS2,PPP1R3DA,FBP1B,CALM,MAP2K2,PTPRF,PRKAG3,INPPL1,PYGB,CALM2A

    Protein Function

    TSC2 has several biochemical functions, for example, 14-3-3 protein binding,GTPase activator activity,phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding ARRB2,AANAT,PRKCE,HDAC7A,KIF13B,AKT1,HDAC7,PRKCZ,RPTOR,SRPK2
    protein homodimerization activity FGFR1,MYPOP,DHDPSL,SEPHS1,NETO2,CER1,NR2C1,VEGFB,Fzd4,TERFA
    small GTPase binding FGD2,ERRFI1,RCC2,FGD3,PEX5,FGD4,RNF152,FGD1,FLNA,ABCA1
    GTPase activator activity STXBP5L,RASAL1,BNIP2,CDC42EP1B,MYO9B,RGS21,AGAP5,SH3BP1,TBC1D2,SGSM2
    phosphatase binding CRY1,ELFN1,PPP1R18,SYTL2,CSRNP2,PPP1R37,ELFN2,DZIP3,DLG1L,SMAD3
    protein binding SET,SYNJ2BP,TRAK1,CDIPT,CAMK2D,TRIM11,PACSIN3,CARS,KIAA1609,SREK1IP1

    Interacting Protein

    TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.

    YWHAB;YWHAZ

    TSC2 Related Signal Pathway

    Resources

    References

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