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TYK2

  • Official Full Name

    tyrosine kinase 2

  • Overview

    This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
  • Synonyms

    TYK2; tyrosine kinase 2; JTK1; non-receptor tyrosine-protein kinase TYK2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • DDK
  • N/A
  • N
  • DYKDDDDK
  • C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TYK2-1505H Active Recombinant Human TYK2, GST-tagged Sf9 Insect Cell GST 442 aa-end
Human TYK2-253H Active Recombinant Human TYK2(875-end) Protein, N-His-tagged Sf21 His 875-end
Human TYK2-3508H Recombinant Human TYK2, His-tagged E.coli His 901-1187aa
Human TYK2-345H Recombinant Human TYK2 Mammalian Cell His
Human TYK2-31641TH Recombinant Human TYK2 Wheat Germ N/A 100 amino acids
Human TYK2-702H Recombinant Human TYK2, His-tagged Sf9 Insect Cell His
Human TYK2-89H Recombinant Human TYK2 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human TYK2-1867HCL Recombinant Human TYK2 cell lysate N/A
Human TYK2-3640H Recombinant Human TYK2 protein, His&Myc-tagged E.coli His&Myc 556-871aa
Human TYK2-2284H-B Recombinant Human TYK2 Protein Pre-coupled Magnetic Beads HEK293
Human TYK2-1452H Recombinant Human TYK2 protein, His-tagged Insect Cell His 589-875aa
Human TYK2-703H Recombinant Human TYK2 protein, His-tagged Insect Cell His Asn 575 - Leu 869
Human TYK2-2284H Recombinant Human TYK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TYK2-03H Recombinant Human TYK2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human TYK2-02H Recombinant Human TYK2 Protein (556-1187), N-DYKDDDDK-tagged Insect Cell N-DYKDDDDK 556-1187
Human TYK2-01H Recombinant Human TYK2 (JH2 domain, 575-869), N-FLAG-tagged Sf9 insect cells N-Flag 575-869
Human TYK228507H Recombinant Human TYK2 (883-1182) (Q969A, E971A, K972A) Protein
Human TYK23052H Recombinant Human TYK2 (888-1178) (Q969A, E971A, K972A) Protein
Human TYK2-636HFL Recombinant Full Length Human TYK2 Protein, C-Flag-tagged Mammalian cells Flag
Human TYK2-6527H Recombinant Human TYK2 Protein (Cys915-His1173), N-His tagged E.coli N-His Cys915-His1173
Human TYK236306H Recombinant Human TYK2 (888-1178) (Q969A, E971A, K972A, C1142A, C939A) Protein
Mouse Tyk2-7156M Recombinant Mouse Tyk2 protein, His & T7-tagged E.coli His/T7 His667~Asp914 (Accession# Q9R117)
Mouse Tyk2-7543M Recombinant Mouse Tyk2 protein(884-1174aa), His&Myc-tagged E.coli N-His&C-Myc 884-1174aa
Kit-1635 TYK2 Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TYK2 Related Signal Pathway

TYK2 involved in several pathways and played different roles in them. We selected most pathways TYK2 participated on our site, such as Osteoclast differentiation, Jak-STAT signaling pathway, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Osteoclast differentiationPPP3CC;NCF2;NFKBIA;NOX3;PIK3R1;NFATC2;SFPI1;FCGR2A;IFNAR1
Jak-STAT signaling pathwayIL12RB1;IL5;IL21R;IFNGR1;PIK3R3A;IFNW1;CRFB16;LEPR;IL2RGB
ToxoplasmosisBIRC8;NOS2;STAT3;IL12A;PPIF;IKBKG;PIK3R1;MAP2K3;Toxoplasma Gondii Dense Granule Protein 7
Hepatitis CCD81;CLDN17;MAPK1;TRADD;IFNA12;IFNA8;CLDN16;PPP2R2D;TRAF3
MeaslesIFNA14;CD209;IRAK1;PIK3CD;STAT5A;CCND3;IKBKE;CD3E; CD3D;IL6
Influenza APRSS3;IFNA12;MAPK9;NLRX1;HSPA8;HLA-DOA;FURIN;IL-8;TMPRSS2
Herpes simplex infectionDDX58;SRSF2B;BF2;IFNA10;IFNG;TRAF6;POU2F3;EEF1DA;TAP2
Epstein-Barr virus infectionPOLR2K;PSMD2;NFKBIE;TRAF3;HLA-DPA1;HLA-DRB1;POLR2H;PIK3R2;FGR

TYK2 has several biochemical functions, for example, ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYK2 itself. We selected most functions TYK2 had, and list some proteins which have the same functions with TYK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMTHFD1B;DDX21;DYNC1LI2;PRKCA;DNAJA1;PIKFYVE;DSTYK;PFKMB;PFKMA
growth hormone receptor bindingGH1;TYK2;Gh;SOCS2;JAK2;JAK1
non-membrane spanning protein tyrosine kinase activityCSK;FRK;Fert2;WEE1;TYK2;MELK;SRMS;YRK;PTK6
protein bindingSTAT5A;SUN1;BRE;TIPRL;SLBP;RUNX2;OSBPL6;RNF111;RBM39
protein tyrosine kinase activityTEK;NTRK3A;ABL2;PTK2;FGFR1OP;MAP2K4;TESK2;ALK;CSK
type 1 angiotensin receptor bindingGNB1;ARRB2;GNA13A;GNG3;ARAP1;TYK2;BDKRB2;AGT;GNA13

TYK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYK2.

KHDRBS2; FHL3; KRT40; HNRPK; TRAF4; E6; E6

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Could TYK2 inhibitors have applications beyond autoimmune diseases? 05/14/2022

Yes, TYK2 inhibitors might have potential in treating certain cancers and possibly other inflammatory conditions beyond autoimmune diseases.

What are the potential benefits of targeting TYK2 in treating autoimmune diseases? 02/09/2021

TYK2 inhibition can potentially reduce inflammation and modulate immune responses without suppressing the entire immune system, unlike some other treatments.

Are there any clinical trials ongoing or completed regarding TYK2 inhibitors? 05/10/2020

Yes, there are several clinical trials evaluating the efficacy and safety of TYK2 inhibitors in various autoimmune diseases.

How do TYK2 inhibitors differ from other treatments for autoimmune diseases? 01/31/2018

TYK2 inhibitors are more targeted, aiming to interfere with specific signaling pathways involved in the immune response compared to broad immunosuppressants.

How are TYK2 inhibitors administered to patients? 11/17/2017

Depending on the formulation, TYK2 inhibitors can be administered orally or through injections.

Customer Reviews (3)

Write a review
Reviews
10/14/2022

    Their expertise in protein production and purification ensures the delivery of a high-quality product that consistently performs well in my experiments.

    06/15/2022

      They are readily available to address any concerns or questions and supply valuable resources to assist in experimental design and optimization.

      01/24/2018

        Should I encounter any challenges or require technical assistance, the manufacturer provides prompt and knowledgeable support.

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