|Official Full Name||tyrosine kinase 2|
|Background||This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]|
|Synonyms||TYK2; tyrosine kinase 2; JTK1; non-receptor tyrosine-protein kinase TYK2;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TYK2 involved in several pathways and played different roles in them. We selected most pathways TYK2 participated on our site, such as Osteoclast differentiation, Jak-STAT signaling pathway, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Osteoclast differentiation||SOCS3; RELB; TGFBR2; LILRA1; PPP3CB; TGFB2; MAPK12; PLCG2; TYROBP; FCGR2A|
|Jak-STAT signaling pathway||PIK3R2; IL15RA; IL24; PIK3CB; PTPN2; IFNL3; IFNA17; AKT1; IL9R; IL5RA|
|Toxoplasmosis||IL10RA; HLA-DPA1; RELA; HLA-DQA1; IFNG; BCL2L1; MAPK8; STAT1; MAP2K3; LAMB4|
|Hepatitis C||TP53; CXCL8; IFNA17; PPP2R2C; IFNA12; MAPK9; PIK3CG; STAT1; TRAF2; CLDN16|
|Measles||CD209C; HSPA8; AKT1; MSN; CD3E; RELA; FAS; OAS1B; CCND2; IRF3|
|Influenza A||HSPA2; DNAJB1; HLA-DMA; XPO1; PIK3R1; PRSS2; IRAK4; SLC25A6; HSPA1A; SOCS3|
|Herpes simplex infection||HLA-F; IFNA8; C3A.2; HLA-DQA1; MAPK8A; C3A.1; IFNA7; TBPL2; TBPL1; IFNA5|
|Epstein-Barr virus infection||POLR3B; NFKBIA; MAPK9; FCER2; PSMC3; MAP3K7; SPI1; MAP2K3; CCNA2; POLR2B|
TYK2 has several biochemical functions, for example, ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYK2 itself. We selected most functions TYK2 had, and list some proteins which have the same functions with TYK2. You can find most of the proteins on our site.
|ATP binding||CDK6; ABL2; UBE2T; HSP104; MCM3; CLCN7; STK3; PRKACG; NPR1A; MAP4K2|
|growth hormone receptor binding||Gh; JAK1; TYK2; GH1; SOCS2; JAK2|
|non-membrane spanning protein tyrosine kinase activity||ITK; YRK; ZAP70; PTK2B; JAK2A; ABL2; BTK; STYK1; FYNA; PTK6|
|protein binding||GDF7; CREM; TLX3; IGF2BP1; STIM1; TCEB2; ITGA6; PLOD3; MEP1B; FBN1|
|protein tyrosine kinase activity||ALK; MAP2K1; EPHB2B; MUSK; KIT; TNK1; JAK2A; MAP2K3; JAK2B; INSRA|
|type 1 angiotensin receptor binding||GNA13B; TYK2; BDKRB2; ARRB2; JAK2; AGT; GNG3; GNA13A; GNA13; ARAP1|
TYK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYK2.
KHDRBS2; FHL3; KRT40; HNRPK; TRAF4; E6; E6