TYK2
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Official Full Name
tyrosine kinase 2
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Overview
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] -
Synonyms
TYK2; tyrosine kinase 2; JTK1; non-receptor tyrosine-protein kinase TYK2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Sf9 insect cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|T7
- DDK
- N/A
- N
- DYKDDDDK
- C
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- TYK2 Related Signal Pathway
TYK2 involved in several pathways and played different roles in them. We selected most pathways TYK2 participated on our site, such as Osteoclast differentiation, Jak-STAT signaling pathway, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | FOSB;NCF1;MAPK1;LCP2;NFATC1;TNFSF11;CALCR;NCF4;TGFBR1 |
| Jak-STAT signaling pathway | CNTF;IL6;IFNB;IFNA2;RAF1;STAT1;SOCS5;PIK3CG;PTPN2 |
| Toxoplasmosis | HLA-DRB1;HLA-DRB4;TYK2;BIRC2;GNAI1;PIK3R1;PIK3R2;HLA-DQA2;TNFRSF1A |
| Hepatitis C | NFKBIA;EIF2AK1;NRAS;IRF1;TRAF6;PIK3R2;RNASEL;IFNA5;Ifna11 |
| Measles | MAP3K7;MX1;MYD88;TLR9;TNFRSF10D;TLR7;CCNE2;PIK3R5;IRF3 |
| Influenza A | BMA2;ACTB;IRF9;ACTG1;HNRNPUL1;IL33;LOC100686744;IFNGR2;IKBKE |
| Herpes simplex infection | MAPK8;IFNPHI3;HLA-DRB1;DAXX;MHC1UEA;PPP1CB;HLA-DRB3;TLR2-1;SRSF6B |
| Epstein-Barr virus infection | POLR2J3;TP53;POLR2D;VIM;PSMD2;HLA-G;HSPA6;PSMD12;EIF2AK3 |
TYK2 has several biochemical functions, for example, ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYK2 itself. We selected most functions TYK2 had, and list some proteins which have the same functions with TYK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RPS6KA4;ACSBG2;OAS2;ACACB;NPR1A;NAV3;ACTR1A;RPS6KAL;CBWD1 |
| growth hormone receptor binding | Gh;JAK2;SOCS2;GH1;JAK1;TYK2 |
| non-membrane spanning protein tyrosine kinase activity | ZAP70;FYNB;PTK2AA;FES;TNK1;ABL2;PTK6B;ZNF143B;PTK2AB |
| protein binding | PA2G4;SYT16;LGALS9C;ITGAX;EGLN2;RRAS;CSRNP1;TIA1;EMG1 |
| protein tyrosine kinase activity | NEK1;EPHA4A;IGF1R;BCR;PDGFRB;EPHB2B;EGFR;RET;FGR |
| type 1 angiotensin receptor binding | AGT;BDKRB2;GNA13B;GNA13A;GNB1;ARRB2;GNG3;ARAP1;JAK2 |
TYK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYK2.
KHDRBS2; FHL3; KRT40; HNRPK; TRAF4; E6; E6
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Customer Reviews (3)
Write a reviewTheir expertise in protein production and purification ensures the delivery of a high-quality product that consistently performs well in my experiments.
They are readily available to address any concerns or questions and supply valuable resources to assist in experimental design and optimization.
Should I encounter any challenges or require technical assistance, the manufacturer provides prompt and knowledgeable support.
Q&As (5)
Ask a questionYes, TYK2 inhibitors might have potential in treating certain cancers and possibly other inflammatory conditions beyond autoimmune diseases.
TYK2 inhibition can potentially reduce inflammation and modulate immune responses without suppressing the entire immune system, unlike some other treatments.
Yes, there are several clinical trials evaluating the efficacy and safety of TYK2 inhibitors in various autoimmune diseases.
TYK2 inhibitors are more targeted, aiming to interfere with specific signaling pathways involved in the immune response compared to broad immunosuppressants.
Depending on the formulation, TYK2 inhibitors can be administered orally or through injections.
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