TYK2

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TYK2

Official Full Name tyrosine kinase 2
Background This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Synonyms TYK2; tyrosine kinase 2; JTK1; non-receptor tyrosine-protein kinase TYK2;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TYK2-1505H Recombinant Human TYK2 (Active), GST-tagged Sf9 Insect Cell GST
    Human TYK2-1867HCL Recombinant Human TYK2 cell lysate N/A
    Human TYK2-31641TH Recombinant Human TYK2 Wheat Germ N/A
    Human TYK2-345H Recombinant Human TYK2 Mammalian Cell His
    Human TYK2-3508H Recombinant Human TYK2, His-tagged E.coli His
    Human TYK2-702H Recombinant Human TYK2, His-tagged Sf9 Insect Cell His
    Human TYK2-89H Recombinant Human TYK2 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse Tyk2-7156M Recombinant Mouse Tyk2 protein, His & T7-tagged E.coli His/T7
    Kit-1635 TYK2 Activity Assay Kit N/A

    TYK2 involved in several pathways and played different roles in them. We selected most pathways TYK2 participated on our site, such as Osteoclast differentiation, Jak-STAT signaling pathway, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Osteoclast differentiation SOCS3; RELB; TGFBR2; LILRA1; PPP3CB; TGFB2; MAPK12; PLCG2; TYROBP; FCGR2A
    Jak-STAT signaling pathway PIK3R2; IL15RA; IL24; PIK3CB; PTPN2; IFNL3; IFNA17; AKT1; IL9R; IL5RA
    Toxoplasmosis IL10RA; HLA-DPA1; RELA; HLA-DQA1; IFNG; BCL2L1; MAPK8; STAT1; MAP2K3; LAMB4
    Hepatitis C TP53; CXCL8; IFNA17; PPP2R2C; IFNA12; MAPK9; PIK3CG; STAT1; TRAF2; CLDN16
    Measles CD209C; HSPA8; AKT1; MSN; CD3E; RELA; FAS; OAS1B; CCND2; IRF3
    Influenza A HSPA2; DNAJB1; HLA-DMA; XPO1; PIK3R1; PRSS2; IRAK4; SLC25A6; HSPA1A; SOCS3
    Herpes simplex infection HLA-F; IFNA8; C3A.2; HLA-DQA1; MAPK8A; C3A.1; IFNA7; TBPL2; TBPL1; IFNA5
    Epstein-Barr virus infection POLR3B; NFKBIA; MAPK9; FCER2; PSMC3; MAP3K7; SPI1; MAP2K3; CCNA2; POLR2B

    TYK2 has several biochemical functions, for example, ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYK2 itself. We selected most functions TYK2 had, and list some proteins which have the same functions with TYK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CDK6; ABL2; UBE2T; HSP104; MCM3; CLCN7; STK3; PRKACG; NPR1A; MAP4K2
    growth hormone receptor binding Gh; JAK1; TYK2; GH1; SOCS2; JAK2
    non-membrane spanning protein tyrosine kinase activity ITK; YRK; ZAP70; PTK2B; JAK2A; ABL2; BTK; STYK1; FYNA; PTK6
    protein binding GDF7; CREM; TLX3; IGF2BP1; STIM1; TCEB2; ITGA6; PLOD3; MEP1B; FBN1
    protein tyrosine kinase activity ALK; MAP2K1; EPHB2B; MUSK; KIT; TNK1; JAK2A; MAP2K3; JAK2B; INSRA
    type 1 angiotensin receptor binding GNA13B; TYK2; BDKRB2; ARRB2; JAK2; AGT; GNG3; GNA13A; GNA13; ARAP1

    TYK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYK2.

    KHDRBS2; FHL3; KRT40; HNRPK; TRAF4; E6; E6

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