Recombinant Human TYK2

• Cat.No.: TYK2-31641TH
• Product Overview: Recombinant fragment of Human TYK2 with a proprietary tag: predicted molecular weight 36.63 kDa.

Specification

• Description: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
• Biological activity: useful for Antibody Production and Protein Array
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: PVCHLRLLAQAEGEPCYIRDSGVAP TDPGPESAAGPPTHEVLVTGTGGIQ WWPVEEEVNKEEGSSGSSGRNPQAS LFGKKAKAHKAVGQPADRPREPLWA
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.Contains 1 FERM domain.Contains 1 protein kinase domain.Contains 1 SH2 domain.
• Tag: Non

Gene Information

• Gene Name: TYK2 tyrosine kinase 2 [ Homo sapiens ]
• Official Symbol: TYK2
• Synonyms: TYK2; tyrosine kinase 2; non-receptor tyrosine-protein kinase TYK2; JTK1
• Gene ID: 7297
• mRNA Refseq: NM_003331
• Protein Refseq: NP_003322
• MIM: 176941
• Uniprot ID: P29597
• Chromosome Location: 19p13.2
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem
• Function: ATP binding; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein tyrosine kinase activity

Reviews

10/14/2022

Their expertise in protein production and purification ensures the delivery of a high-quality product that consistently performs well in my experiments.

06/15/2022

They are readily available to address any concerns or questions and supply valuable resources to assist in experimental design and optimization.

01/24/2018

Should I encounter any challenges or require technical assistance, the manufacturer provides prompt and knowledgeable support.

Q&As

Could TYK2 inhibitors have applications beyond autoimmune diseases?

Yes, TYK2 inhibitors might have potential in treating certain cancers and possibly other inflammatory conditions beyond autoimmune diseases.

What are the potential benefits of targeting TYK2 in treating autoimmune diseases?

TYK2 inhibition can potentially reduce inflammation and modulate immune responses without suppressing the entire immune system, unlike some other treatments.

Are there any clinical trials ongoing or completed regarding TYK2 inhibitors?

Yes, there are several clinical trials evaluating the efficacy and safety of TYK2 inhibitors in various autoimmune diseases.

How do TYK2 inhibitors differ from other treatments for autoimmune diseases?

TYK2 inhibitors are more targeted, aiming to interfere with specific signaling pathways involved in the immune response compared to broad immunosuppressants.

How are TYK2 inhibitors administered to patients?

Depending on the formulation, TYK2 inhibitors can be administered orally or through injections.