Recombinant Full Length Human TYK2 Protein, C-Flag-tagged

• Cat.No.: TYK2-636HFL
• Product Overview: Recombinant Full Length Human TYK2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 133.7 kDa
• AA Sequence: MPLRHWGMARGSKPVGDGAQPMAAM GGLKVLLHWAGPGGGEPWVTFSESS LTAEEVCIHIAHKVGITPPC FNLFALFDAQAQVWLPPNHILEIPR DASLMLYFRIRFYFRNWHGMNPREP AVYRCGPPGTEASSDQTAQG MQLLDPASFEYLFEQGKHEFVNDVA SLWELSTEEEIHHFKNESLGMAFLH LCHLALRHGIPLEEVAKKTS FKDCIPRSFRRHIRQHSALTRLRLR NVFRRFLRDFQPGRLSQQMVMVKYL ATLERLAPRFGTERVPVCHL RLLAQAEGEPCYIRDSGVAPTDPGP ESAAGPPTHEVLVTGTGGIQWWPVE EEVNKEEGSSGSSGRNPQAS LFGKKAKAHKAVGQPADRPREPLWA YFCDFRDITHVVLKEHCVSIHRQDN KCLELSLPSRAAALSFVSLV DGYFRLTADSSHYLCHEVAPPRLVM SIRDGIHGPLLEPFVQAKLRPEDGL YLIHWSTSHPYRLILTVAQR SQAPDGMQSLRLRKFPIEQQDGAFV LEGWGRSFPSVRELGAALQGCLLRA GDDCFSLRRCCLPQPGETSN LIIMRGARASPRTLNLSQLSFHRVD QKEITQLSHLGQGTRTNVYEGRLRV EGSGDPEEGKMDDEDPLVPG RDRGQELRVVLKVLDPSHHDIALAF YETASLMSQVSHTHLAFVHGVCVRG PENIMVTEYVEHGPLDVWLR RERGHVPMAWKMVVAQQLASALSYL ENKNLVHGNVCGRNILLARLGLAEG TSPFIKLSDPGVGLGALSRE ERVERIPWLAPECLPGGANSLSTAM DKWGFGATLLEICFDGEAPLQSRSP SEKEHFYQRQHRLPEPSCPQ LATLTSQCLTYEPTQRPSFRTILRD LTRLQPHNLADVLTVNPDSPASDPT VFHKRYLKKIRDLGEGHFGK VSLYCYDPTNDGTGEMVAVKALKAD CGPQHRSGWKQEIDILRTLYHEHII KYKGCCEDQGEKSLQLVMEY VPLGSLRDYLPRHSIGLAQLLLFAQ QICEGMAYLHSQHYIHRDLAARNVL LDNDRLVKIGDFGLAKAVPE GHEYYRVREDGDSPVFWYAPECLKE YKFYYASDVWSFGVTLYELLTHCDS SQSPPTKFLELIGIAQGQMT VLRLTELLERGERLPRPDKCPCEVY HLMKNCWETEASFRPTFENLIPILK TVHEKYQGQAPSVFSVCTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Jak-STAT signaling pathway

Gene Information

• Gene Name: TYK2 tyrosine kinase 2 [ Homo sapiens (human) ]
• Official Symbol: TYK2
• Synonyms: JTK1; IMD35
• Gene ID: 7297
• mRNA Refseq: NM_003331.5
• Protein Refseq: NP_003322.3
• MIM: 176941
• UniProt ID: P29597