Recombinant Human TYK2 Protein (556-1187), N-DYKDDDDK-tagged

• Cat.No.: TYK2-02H
• Product Overview: Human TYK2, catalytic/pseudo-kinase domain [556-1187(end) amino acids of accession number NP_003322.3] was expressed as N-terminal DYKDDDDK tagged, biotinylated protein (76 kDa) using baculovirus expression system. The protein was purified by using DYKDDDDK tag antibody agarose.

Specification

• Description: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
• Source: Insect cells
• Species: Human
• Tag: N-DYKDDDDK
• Molecular Mass: 76 kDa
• Protein Length: 556-1187
• Purity: 85%
• Storage: Store at -80 centigrade.
  Avoid repeating freeze-thaws.
• Storage Buffer: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5

Gene Information

• Gene Name: TYK2 tyrosine kinase 2 [ Homo sapiens (human) ]
• Official Symbol: TYK2
• Synonyms: TYK2; tyrosine kinase 2; JTK1; IMD35; non-receptor tyrosine-protein kinase TYK2; EC 2.7.10.2
• Gene ID: 7297
• mRNA Refseq: NM_003331
• Protein Refseq: NP_003322
• MIM: 176941
• UniProt ID: P29597