Recombinant Human TYK2 (JH2 domain, 575-869), N-FLAG-tagged

• Cat.No.: TYK2-01H
• Product Overview: Human recombinant TYK2 (Non-receptor tyrosine-protein kinase TYK2), encompassing amino acids 575-869 containing pseudo-kinase domain JH2. This construct contains an N-terminal Flag-tag. The recombinant protein was affinity purified.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Flag
• Protein Length: 575-869
• Description: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
• Form: Aqueous buffer solution
• Molecular Mass: 34 kDa
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 3 mM DTT

Gene Information

• Gene Name: TYK2 tyrosine kinase 2 [ Homo sapiens (human) ]
• Official Symbol: TYK2
• Synonyms: TYK2; tyrosine kinase 2; JTK1; IMD35; non-receptor tyrosine-protein kinase TYK2; EC 2.7.10.2
• Gene ID: 7297
• mRNA Refseq: NM_003331
• Protein Refseq: NP_003322
• MIM: 176941
• UniProt ID: P29597