• Official Full Name
  • ubiquitin-like modifier activating enzyme 1
  • Background
  • Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which targets a protein for degradation via a proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-transcriptional modification by ubiquitin and ubiquitin-like proteins.
  • Synonyms
  • UBA1; ubiquitin-like modifier activating enzyme 1; A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; MGC4781; ubiquitin-like modifier-activating enzyme 1
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human UBA1 Protein, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human UBA1 Protein, MYC/DDK-tagged
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UBA1
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human UBA1, GST-tagged
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Ubiquitin-like Modifier Activating Enzyme 1
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human UBA1 Protein, GST-tagged, Active
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human UBA1, His & GST tagged
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human UBA1, GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UBA1 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBA1
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human UBA1 cell lysate

Involved Pathway

UBA1 involved in several pathways and played different roles in them. We selected most pathways UBA1 participated on our site, such as Ubiquitin mediated proteolysis, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
Parkinsons disease
ATP5C1; COX7A1; Casp3; NDUFC2-KCTD14; PPIF; TH; Atp5g2; UBE2G1; UBE1Y1; NDUFB1

Protein Function

UBA1 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA1 itself. We selected most functions UBA1 had, and list some proteins which have the same functions with UBA1. You can find most of the proteins on our site.
Related Protein
Function ATP binding
Related Protein ORC1L; NRBP2; CLCN5; NEK6; CHEK2; ABCC9; IGF1R; STK38; FARSB; MINK1
Function poly(A) RNA binding
Related Protein MCAT; HIST1H1C; HSD17B10; RPL10; NUPL2; GTPBP4; FAM46A; RSL24D1; MRPL28; MRPL42
Function protein binding
Related Protein VAV2; TOP1; OCIAD1; KLRC4-KLRK1; GLI3; FAM206A; SNX6; ELF3; PTPRO; STRAP
Function ubiquitin activating enzyme activity
Related Protein UBA7; UBE1Y1; SAE1; UBA1; UBA6; ATG7
Function ubiquitin-protein transferase activity
Related Protein FBXO2; TRIM56; KLHL20; FBXL5; RNF4; MGRN1; UBE2D3; UBE3A; CBL; ZNRF1

Interacting Protein

UBA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA1.
GAN; BIRC3; MAGEC2; q76353_9hiv1; CCDC69; YAF2; HIP1; RIOK3; HGS; MDM4; RNF13; HIP1R; DNAJB6