UBA1
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Official Full Name
ubiquitin-like modifier activating enzyme 1 -
Overview
Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which targets a protein for degradation via a proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-transcriptional modification by ubiquitin and ubiquitin-like proteins. -
Synonyms
UBA1;ubiquitin-like modifier activating enzyme 1;A1S9;A1ST;GXP1;UBE1;A1S9T;AMCX1;POC20;SMAX2;UBA1A;UBE1X;MGC4781;ubiquitin-like modifier-activating enzyme 1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Insect Cells
- Mammalian Cells
- Sf9 Cells
- HEK293
- Non
- GST
- His
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
UBA1 involved in several pathways and played different roles in them. We selected most pathways UBA1 participated on our site, such as Ubiquitin mediated proteolysis,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | NDUFS7,UBE2L3,SNCAIP,NDUFB3,DRD1A,COX7B2,ATP5B,NDUFB4,GPR37,NDUFA9 |
| Ubiquitin mediated proteolysis | FBXO2,UBE2F,MDM2,CUL1,UBE4B,FBXW11B,FZR1,CDC34,SOCS1,AIRE |
Protein Function
UBA1 has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA1 itself. We selected most functions UBA1 had, and list some proteins which have the same functions with UBA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | JUN,ZC3H11A,ANXA2,PUS1,SRSF4,LSM14A,SNRPN,ARCN1,RARS2,DHX37 |
| ATP binding | RTCD1,ABCB1,MAPK13,TCP1,ABCA13,OASL1,IGF1R,CDK15,CKMB,HSPA4B |
| protein binding | MSI2,CSPG5,LSM4,ZC4H2,RIPK3,LRRK2,ARL4A,FECH,DHX16,NIPBL |
| ubiquitin-protein transferase activity | PJA2,RNF181,BIRC2,TRAF4A,UBE2A,UBE2D2A,RNF13,TRIM32,RC3H2,UBR4 |
| ubiquitin activating enzyme activity | UBA6,UBE1Y1,ATG7,SAE1,UBA7 |
Interacting Protein
UBA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA1.
GAN;BIRC3;MAGEC2;q76353_9hiv1;CCDC69;YAF2;HIP1;RIOK3;HGS;MDM4;RNF13;HIP1R;DNAJB6
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