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UBA1

  • Official Full Name

    ubiquitin-like modifier activating enzyme 1

  • Overview

    Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which targets a protein for degradation via a proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-transcriptional modification by ubiquitin and ubiquitin-like proteins.
  • Synonyms

    UBA1; ubiquitin-like modifier activating enzyme 1; A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; MGC4781; ubiquitin-like modifier-activating enzyme 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBA1-105H Active Recombinant Human UBA1 E.coli N/A
Human UBA1-641H Active Recombinant Human UBA1 Protein, GST-tagged Insect Cell GST
Human UBA1-476H Recombinant Human UBA1, GST-tagged Sf9 Insect Cell Flag
Human UBA1-7333H Recombinant Human UBA1 protein(Ser2-Arg1058), His&GST-tagged Insect Cells N-His&GST Ser2-Arg1058
Human UBA1-832H Recombinant Human UBA1, GST-tagged Sf9 Insect Cell GST Full length
Human UBA1-58H Recombinant Human Ubiquitin-like Modifier Activating Enzyme 1 Sf9 Insect Cell N/A
Human UBA1-420HCL Recombinant Human UBA1 cell lysate Insect Cell N/A
Human UBA1-264H Recombinant Human UBA1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human UBA1-337H Recombinant Human UBA1 Protein, His-tagged Insect Cells His
Human UBA1-212H Recombinant Human UBA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse Uba1-6764M Recombinant Mouse Uba1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat UBA1-6385R Recombinant Rat UBA1 Protein Mammalian Cell His
Rat UBA1-6041R-B Recombinant Rat UBA1 Protein Pre-coupled Magnetic Beads HEK293
Rat UBA1-6041R Recombinant Rat UBA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish UBA1-12294Z Recombinant Zebrafish UBA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UBA1 involved in several pathways and played different roles in them. We selected most pathways UBA1 participated on our site, such as Ubiquitin mediated proteolysis, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisCUL3;CUL1;HERC4;SOCS3;TRAF6;UBE2L3;CUL4B;UBE2G1B;UBE2E2
Parkinsons diseaseNDUFB1;COX4I2;SLC25A6;NDUFA9;HTRA2;NDUFB2;NDUFB5;NDUFS5;NDUFA1

UBA1 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA1 itself. We selected most functions UBA1 had, and list some proteins which have the same functions with UBA1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingGK;MAPK8;UBE2G1A;NDUFA13;ACLY;ORC4;MAP2K4A;KIT;UBE2IB
poly(A) RNA bindingRPL7;EIF2AK2;HTATSF1;RRP1;EIF4ENIF1;ELAVL1;EIF2S1;PUF60;ZFP622
protein bindingCOG8;JUN;NR2F2;NUDT18;USP9X;DDX41;TSPAN12;CAB39;PIK3C2B
ubiquitin activating enzyme activityUBA6;ATG7;SAE1;UBE1Y1;UBA1;UBA7
ubiquitin-protein transferase activityUBE2D2A;BRCA1;IRAK1;BTR22;PDZRN3B;RNF168;MALT1;HERC2;RC3H2

UBA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA1.

GAN; BIRC3; MAGEC2; q76353_9hiv1; CCDC69; YAF2; HIP1; RIOK3; HGS; MDM4; RNF13; HIP1R; DNAJB6

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any clinical trials involving UBA1 as a target? 04/20/2023

Some early-phase clinical trials are exploring UBA1 as a potential target in the context of ALS and cancer.

How can UBA1 be targeted for therapeutic purposes? 09/19/2020

Targeting UBA1 with small molecules or gene therapy may provide a potential avenue for treating UBA1-related diseases.

How does UBA1 function in the cell? 12/04/2017

UBA1 activates ubiquitin, a small protein that tags other proteins for degradation by the proteasome.

What diseases are associated with UBA1 dysfunction? 07/19/2017

UBA1 dysfunction has been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and certain types of cancer.

Can UBA1 be a diagnostic marker for ALS? 08/16/2016

Research suggests that altered UBA1 levels in the cerebrospinal fluid may be a potential biomarker for ALS diagnosis.

Customer Reviews (3)

Write a review
Reviews
07/02/2022

    The UBA1 protein comes highly recommended for its outstanding performance in various experimental applications.

    07/07/2019

      In ELISA assays, it has consistently exhibited exceptional reliability and accuracy, providing precise and reproducible results.

      05/13/2017

        Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the UBA1 protein in my studies.

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