UBE2D2
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Official Full Name
ubiquitin-conjugating enzyme E2D 2
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Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. -
Synonyms
UBE2D2; ubiquitin-conjugating enzyme E2D 2; ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 D2; UBC4; UbcH5B; ubiquitin-protein ligase D2; ubiqu;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Xenopus laevis
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- UBE2D2 Related Research Area
UBE2D2 involved in several pathways and played different roles in them. We selected most pathways UBE2D2 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2D2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | SOCS1;UBE2G1;CUL5;AIRE;RHOBTB2;CUL3B;SMURF1;BIRC7;SAE1 |
| Protein processing in endoplasmic reticulum | NSFL1C;FBXO2;SSR3;DNAJC3;HSPA1L;MBTPS1;MAPK9;MAP2K7;WFS1 |
| Shigellosis | PFN2;CD44;ELMO1;ABL1;UBE2D2;RAC1;MAPK9;ACTB;ACTG1 |
UBE2D2 has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2D2 itself. We selected most functions UBE2D2 had, and list some proteins which have the same functions with UBE2D2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | UCK2;SYN2B;AARS2;PMVK;LACE1A;CDK5;ATP2B2;FLT3;TRIP13 |
| protein binding | RPS11;INPP5B;SLC19A2;AGER;PHC2;NKG7;ABI3;LMLN;PSAP |
| ubiquitin conjugating enzyme activity | UBE2D4;UBE2V2;UBE2L3;UBE2B;UBE2G2;UBE2V1;UBE2D2A;UBE2J1;UBE2E1 |
| ubiquitin-protein transferase activity | PRP19;UBE2M;RNF152;UHRF1;RNF31;MKRN1;TRAF7;ZYG11;UBE2L6 |
UBE2D2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2D2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2D2.
RNF11; OTUB1; ZNRF1; RNF5; RNF43; MDM4
- Q&As
- Reviews
Q&As (7)
Ask a questionUBE2D2 works in tandem with other ubiquitin-proteasome system components, orchestrating protein degradation.
It facilitates the attachment of ubiquitin to target proteins, directing them to the proteasome for breakdown.
UBE2D2 plays a role in controlling the cell cycle by regulating the degradation of key cycle-related proteins.
Targeting UBE2D2 could offer new treatments for conditions involving protein misfolding and aggregation.
Altered UBE2D2 activity is linked with several diseases, including cancer and neurodegenerative disorders.
Genetic mutations in UBE2D2 can disrupt protein turnover, affecting various cellular functions and stability.
UBE2D2, a ubiquitin-conjugating enzyme, is vital for tagging proteins with ubiquitin, marking them for degradation.
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