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Official Full Name ubiquitin-conjugating enzyme E2D 2
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
Synonyms UBE2D2; ubiquitin-conjugating enzyme E2D 2; ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 D2; UBC4; UbcH5B; ubiquitin-protein ligase D2; ubiqu
    • Species :
    • Human
    • Rat
    • Xenopus laevis
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2D2-243H Recombinant Human UBE2D2 Protein, His-tagged E.coli His
    Human UBE2D2-30042TH Recombinant Human UBE2D2 E.coli N/A
    Human UBE2D2-31647TH Recombinant Human UBE2D2, His-tagged E.coli His
    Human UBE2D2-37H Recombinant Human UBE2D2, His-tagged E.coli His
    Human UBE2D2-38H Recombinant Human UBE2D2 E.coli N/A
    Human UBE2D2-5438H Recombinant Human UBE2D2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UBE2D2-587HCL Recombinant Human UBE2D2 293 Cell Lysate HEK293 N/A
    Human UBE2D2-588HCL Recombinant Human UBE2D2 293 Cell Lysate HEK293 N/A
    Human UBE2D2-6315H Recombinant Human UBE2D2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UBE2D2-645H Recombinant Human UBE2D2 Protein, His-tagged, Active E.coli His
    Human UBE2D2-67H Recombinant Human UBE2D2 Protein E.coli N/A
    Human UBE2D2-71H Recombinant Human UBE2D2, His-tagged E.coli His
    Rat UBE2D2-6396R Recombinant Rat UBE2D2 Protein Mammalian Cell His
    Xenopus laevis ube2d2-236X Recombinant Xenopus ube2d2, His-tagged E.coli His

    ube2d2 involved in several pathways and played different roles in them. We selected most pathways ube2d2 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube2d2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis UBE2L3B; UBE3C; CDC23; UBE2R2; UBE2KA; TCEB2; UBE3A; FBXW11B; CUL1A; UBE2G2
    Protein processing in endoplasmic reticulum SEL1L2; CRYAB; SEC31B; DNAJC1; EIF2AK3; MAPK8B; BAG1; RBX1; MAPK10; SYVN1
    Shigellosis ACTB; RHOG; ELMO3; PFN2; MAPK3; ROCK1; ELMO2; CD44; U2AF1; PFN4

    ube2d2 has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ube2d2 itself. We selected most functions ube2d2 had, and list some proteins which have the same functions with ube2d2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CNPY2; TRIM35; FAM133A; CPNE1; DDIT3; NEDD4L; BCL7B; NUAK1; MAP2K4; PDCD10
    ubiquitin conjugating enzyme activity UBE2E2; UBE2S; UBE2C; UBE2D3; UBE2V1; UBE2E3; UBE2T; UBE2B; UBE2V2; UBE2O
    ubiquitin-protein transferase activity MUL1; TRAF2; AMFR; UBE2B; FBXO2; PEX2; RNF144AA; TRIM23; ZNRF1; MARCH8

    ube2d2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube2d2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ube2d2.

    RNF11; OTUB1; ZNRF1; RNF5; RNF43; MDM4

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