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UBE2K

  • Official Full Name

    ubiquitin-conjugating enzyme E2K

  • Overview

    The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING;finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntingtons disease. Known functions for;this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis;in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the;endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different;isoforms have been identified for this gene.
  • Synonyms

    UBE2K; ubiquitin-conjugating enzyme E2K; HIP2, huntingtin interacting protein 2 , ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-conjugating enzyme E2 K; HYPG; UBC1; HIP-2; E2(25K); ubiquitin-protein ligase; ubiquitin carrier protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBE2K-649H Active Recombinant Human UBE2K Protein, His-tagged E.coli His
Human UBE2K-29321TH Recombinant Human UBE2K E.coli N/A 200 amino acids
Human UBE2K-3537H Recombinant Human UBE2K, GST-tagged E.coli GST 1-200aa
Human UBE2K-1790H Recombinant Human Ubiquitin-Conjugating Enzyme E2K, His-tagged Human His
Human UBE2K-208H Recombinant Human UBE2K protein E.coli N/A 208
Human UBE2K-4758H Recombinant Human UBE2K Protein, GST-tagged Wheat Germ GST
Human UBE2K-131H Recombinant Human UBE2K E.coli N/A
Human UBE2K-571HCL Recombinant Human UBE2K 293 Cell Lysate HEK293 N/A
Human UBE2K-3532HF Recombinant Full Length Human UBE2K Protein, GST-tagged In Vitro Cell Free System GST 200 amino acids
Human UBE2K-4276H Recombinant Human UBE2K Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UBE2K-0045H Recombinant Human UBE2K Protein (A2-N200), His/Strep tagged Insect Cell His/Strep A2-N200
Human UBE2K-0044H Recombinant Human UBE2K Protein (A2-N200), Tag Free Insect Cell No tag A2-N200
Mouse UBE2K-17722M Recombinant Mouse UBE2K Protein Mammalian Cell His
Mouse Ube2k-6791M Recombinant Mouse Ube2k Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse UBE2K-9831M Recombinant Mouse UBE2K Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse UBE2K-9831M-B Recombinant Mouse UBE2K Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque UBE2K-5063R Recombinant Rhesus monkey UBE2K Protein, His-tagged Mammalian Cell His
Rhesus Macaque UBE2K-4876R Recombinant Rhesus Macaque UBE2K Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque UBE2K-4876R-B Recombinant Rhesus Macaque UBE2K Protein Pre-coupled Magnetic Beads HEK293
Chicken UBE2K-3184C Recombinant Chicken UBE2K Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UBE2K Related Articles
  • UBE2K Related Research Area

UBE2K involved in several pathways and played different roles in them. We selected most pathways UBE2K participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisPIAS4B;UBE2IA;UBE2I;TRIM32;RHOBTB2;UBE2NA;SIAH1A;SOCS3B;UBE2N

UBE2K has several biochemical functions, for example, ATP binding, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2K itself. We selected most functions UBE2K had, and list some proteins which have the same functions with UBE2K. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAP2K4;DNAJA3B;CSNK1D;BMP2K;PANK1B;FIGN;VARS;ANKK1;NLRP9C
protein bindingCRY1A;KIAA0141;LARS;PEAK1;GPX3;GFM2;NIF3L1;TMEM242;HAAO
ubiquitin protein ligase bindingBID;STUB1;TMBIM6;ARIH1;UBE2V1;UCHL1;RNF31;NPLOC4;H2-AB1
ubiquitin-protein transferase activityUBR4;LNX2B;UBE2M;RNF168;CBLL1;PEX12;MALT1;NSMCE1;RNF41
ubiquitin-ubiquitin ligase activityUBE4B;UBOX5;ANAPC11;AMFR;PPIL2;RBX1;UBE2K;PRPF19;STUB1

UBE2K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2K here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2K.

SIAH1; RNF138; REL; DTX3; MIPOL1; DDI1

Rajsbaum, R; Versteeg, GA; et al. Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKK epsilon Kinase-Mediated Antiviral Response. IMMUNITY 40:880-895(2014).
Filatova, EV; Shadrina, MI; et al. Expression analysis of genes of ubiquitin-proteasome protein degradation system in MPTP-induced mice models of early stages of Parkinson's disease. DOKLADY BIOCHEMISTRY AND BIOPHYSICS 456:116-118(2014).
  • Q&As
  • Reviews

Q&As (5)

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Is UBE2K a potential biomarker for any diseases? 06/14/2021

UBE2K expression levels are being investigated as potential biomarkers for certain cancers and neurodegenerative diseases, offering insights into disease progression and prognosis.

How does UBE2K influence protein quality control in cells? 03/04/2021

UBE2K is involved in the ubiquitination of misfolded or damaged proteins, marking them for degradation, thus contributing to protein quality control mechanisms within cells.

Can targeting UBE2K be a strategy for personalized medicine? 05/03/2020

The potential role of UBE2K as a therapeutic target suggests that personalized medicine approaches could be developed based on the specific molecular characteristics of a patient's disease.

Are there any known genetic variations in the UBE2K gene associated with diseases? 06/08/2019

Genetic variations in the UBE2K gene have been explored for associations with certain diseases, providing insights into the genetic basis of UBE2K-related disorders.

How does UBE2K contribute to the immune response? 06/28/2017

UBE2K is involved in the ubiquitination of proteins in the immune signaling pathways, influencing the immune response and inflammation.

Customer Reviews (3)

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Reviews
12/05/2022

    This protein is known for its exceptional quality and purity, providing reliable and consistent results.

    12/20/2021

      Its high specificity and functional integrity ensure accurate and reproducible data, allowing researchers to draw meaningful conclusions from their experiments.

      10/13/2016

        The UBE2K protein offers numerous advantages in trials and research experiments, making it an excellent choice for researchers.

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