|Official Full Name||ubiquitin-conjugating enzyme E2K|
|Background||The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING;finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntingtons disease. Known functions for;this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis;in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the;endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different;isoforms have been identified for this gene.|
|Synonyms||UBE2K; ubiquitin-conjugating enzyme E2K; HIP2, huntingtin interacting protein 2 , ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-conjugating enzyme E2 K; HYPG; UBC1; HIP-2; E2(25K); ubiquitin-protein ligase; ubiquitin carrier protein|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ube2k involved in several pathways and played different roles in them. We selected most pathways ube2k participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube2k were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ubiquitin mediated proteolysis||UBE2G1A; MDM2; UBE4B; NHLRC1; BIRC8; PPIL2; PIAS4B; SIAH2L; UBA7; ERCC8|
ube2k has several biochemical functions, for example, ATP binding, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ube2k itself. We selected most functions ube2k had, and list some proteins which have the same functions with ube2k. You can find most of the proteins on our site.
|ATP binding||HK3; P2RY2; BRIP1; RAF1B; NADK2; PKDCCA; ACTR2A; PRKCBB; FARS2; TAP1|
|protein binding||SENP3; SNX10; SH2D1A; HPCAL4; PELO; KLHL2; HOMER1; FRS3; ZNF177; PSMA4|
|ubiquitin protein ligase binding||TCP1; GPI; ARIH1; SUMO1; PA2G4; SLC22A18; PIAS4; MC4R; ERLIN2; C10orf46|
|ubiquitin-protein transferase activity||RNF139; TRIM24; MYCBP2; RNF168; ARIH2; CNOT4; TRIM33; XIAP; FBXO4; HECTD1|
|ubiquitin-ubiquitin ligase activity||PPIL2; RBX1; UBE4B; UBOX5; ANAPC11; UBE2K; AMFR; STUB1; PRPF19|
ube2k has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube2k here. Most of them are supplied by our site. Hope this information will be useful for your research of ube2k.
SIAH1; RNF138; REL; DTX3; MIPOL1; DDI1