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UBR1

Official Full Name

ubiquitin protein ligase E3 component n-recognin 1
Overview

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]
Synonyms

UBR1; ubiquitin protein ligase E3 component n-recognin 1; JBS; E3 ubiquitin-protein ligase UBR1; E3a ligase; N-recognin-1; ubiquitin ligase E3 alpha-I; ubiquitin-protein ligase E3-alpha; ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein ligase E3-alpha-I;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	UBR1-08H	Recombinant Human UBR1 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	UBR1-17760M	Recombinant Mouse UBR1 Protein	Mammalian Cell	His	Inquiry
Mouse	UBR1-9859M-B	Recombinant Mouse UBR1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	UBR1-9859M	Recombinant Mouse UBR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
UBR1 Related Articles

UBR1 involved in several pathways and played different roles in them. We selected most pathways UBR1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	CTSE;CTSL1;ASB7;CTSL2;LILRA2;TRAT1;ACTR1A;LILRB3;UBR2
Antigen processing: Ubiquitination &amp	UBE2V2;TRIM9;ARIH2;FBXO17;RNF144B;UBR2;HUWE1;TPP2;DTX3L
Proteasome degradation	ASB6;LRSAM1;PJA1;ARIH2;UBA5;UBE2V2;RBCK1;TRIM63;UBE2V1
Class I MHC mediated antigen processing &amp	SEC23A;B2ML;ASB2;UBE2F;STUB1;SPSB2;SEC61B;DTX3L;RNF19B
presentation	UBA5;ASB8;UBE2J2;UBR2;LRRC41;WSB1;FCGR1B;RNF111;RNF41
Immune System	CD300LB;KIF26A;UNC93B1;KPNA3;RNF220;LILRA2;KIF2B;DUSP3B;WASF3

UBR1 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBR1 itself. We selected most functions UBR1 had, and list some proteins which have the same functions with UBR1. You can find most of the proteins on our site.

Function	Related Protein
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	RNF144AA;RNF149;RNF187;ZNRF3;ITCHA;MARCH5L;UBE2IB;NEURL1B;RC3H2
coenzyme F420-0 gamma-glutamyl ligase activity	RNF149;SHRPRBCK1R;RNF144AB;TMEM129;HECW2;LTN1;MARCH6;TRIM71;RNF187
coenzyme F420-2 alpha-glutamyl ligase activity	RFWD2;ZNRF2B;SIAH1A;ARIH1L;RNF144AA;HERC2;RNF144AB;MARCH11;SIAH2L
leucine binding	GLUD2;UBR2;GLUD1;UBR1
ligase activity	BARD1;RFFL;DTX2;MARCH11;HERC3;RNF114;TRIM22;RNF123;RBX1
metal ion binding	SHRPRBCK1R;CYP2AA8;CNOT8;ZNF559;TP63;ANTXR2;PLA2G12B;SALL3;SCRT2
protein binding	CAMKK1;SPG20;PJA1;RALGDS;ARF6;MRAP;GNG10;C9orf86;LMX1A
protein-glutamic acid ligase activity	NEURL1B;MARCH5L;UBE2IA;MGRN1A;RNF187;TRIM41;TRIM71;ZNRF2B;RC3H2
protein-glycine ligase activity	RNF169;RNF187;TRIM50;DTX1;TRIM71;ARIH1L;MYLIPA;ZNRF2B;MARCH11
protein-glycine ligase activity, elongating	MGRN1A;ZNRF2B;SIAH1A;NEURL1B;MYLIPA;HERC2;RNF187;DTX1;TRIM50
protein-glycine ligase activity, initiating	NEURL1B;ITCHA;HECW2;RNF180;TRIM41;MARCH6;MARCH9;RNF144AA;DTX1
ribosomal S6-glutamic acid ligase activity	UBE2IA;NEURL3;MYLIPA;ZNRF3;ARIH1L;SHRPRBCK1R;NEURL1B;UBE2IB;RNF180
tubulin-glutamic acid ligase activity	TMEM129;TTLL1;G2E3;DTX1;RNF180;NEURL3;HERC2;MUL1A;SIAH2L
tubulin-glycine ligase activity	RNF187;UBE2IA;UBE2IB;ITCHA;HECW2;HERC2;SHRPRBCK1R;RNF144AB;ZNRF3
ubiquitin protein ligase activity	UBE2V1;RNF220;RNF34;RNF7;CDC34A;RNF121;UBE2KB;TRIM72;TRIM6
ubiquitin-protein transferase activity	MKRN1;MARCH5;RNF187;UBE2R2;UBE3C;UBA7;FBXO3;BIRC5B;UBE2E1
zinc ion binding	KDM2BA;GFI1AA;MYLIP;ZFP598;GTF2H2C_2;RBM4.1;TRIM105;KAT6A;THRA

UBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBR1.

Sos1; Trpm7

Scazzari, M; Amm, I; et al. Quality Control of a Cytoplasmic Protein Complex CHAPERONE MOTORS AND THE UBIQUITIN-PROTEASOME SYSTEM GOVERN THE FATE OF ORPHAN FATTY ACID SYNTHASE SUBUNIT Fas2 OF YEAST. JOURNAL OF BIOLOGICAL CHEMISTRY 290:4677-4687(2015).

Kawai, K; Moriya, A; et al. Functional Implications and Ubiquitin-Dependent Degradation of the Peptide Transporter Ptr2 in Saccharomyces cerevisiae. EUKARYOTIC CELL 13:1380-1392(2014).