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UGT1A4

Official Full Name

UDP glucuronosyltransferase 1 family, polypeptide A4
Overview

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
Synonyms

UGT1A4; UDP glucuronosyltransferase 1 family, polypeptide A4; UDP glycosyltransferase 1 family, polypeptide A4; UDP-glucuronosyltransferase 1-4; HUG BR2; UGT1D; Bilirubin UDP glucuronosyltransferase isozyme 2; Bilirubin-specific UDPGT isozyme 2; HUG-BR2; UD14_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A4; UDP glycosyltransferase 1 family polypeptide A4; UDP-glucuronosyltransferase 1-D; UDP-glucuronosyltransferase 1A4; UDPGT 1-4; UDPGT; UGT-1D; UGT1*4; UGT1-04; UGT1.4; bilirubin UDP-glucuronosyltransferase isozyme 2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Homo sapiens (Human)
Human
Zebrafish

Source

E.coli
E.coli expression system
HEK293
HEK293T
Insect cells
Mamanlian cells
Mammalian Cell

Tag

Flag
His
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UGT1A4-38H	Recombinant Human UGT1A4, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	UGT1A4-512HCL	Recombinant Human UGT1A4 293 Cell Lysate	HEK293	Non		Inquiry
Human	UGT1A4-2109H	Recombinant Human UGT1A4 Protein (29-534 aa), His-tagged	E.coli	His	29-534 aa	Inquiry
Human	UGT1A4-3950HFL	Recombinant Full Length Human UGT1A4, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	UGT1A4-6011H	Recombinant Human UGT1A4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	UGT1A4-103H	Recombinant Human UGT1A4 Protein	Insect cells			Inquiry
Homo sapiens (Human)	RFL21825HF	Recombinant Full Length Human Udp-Glucuronosyltransferase 1-4(Ugt1A4) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (29-534)	Inquiry
Zebrafish	UGT1A4-7724Z	Recombinant Zebrafish UGT1A4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

UGT1A4 involved in several pathways and played different roles in them. We selected most pathways UGT1A4 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	AKR1B8;UGT2B15;UGP2;UGT2B7;UGT1A1;UGT5G1;UGT1A4;ALDH3A2A;OXSR1
Ascorbate and aldarate metabolism	ALDH9A1A.1;UGT2A3;UGT1A4;UGT2B7;RGN;UGT1A3;UGT2B15;ALDH9A1;UGT1A6A
Steroid hormone biosynthesis	UGT1A7C;UGT1A1;UGT1A9;AKR1D1;CYP2C70;CYP2C55;HSD3B5;UGT2B7;CYP3A41B
Starch and sucrose metabolism	UXS1;UGT1A4;PYGM;SI;GYS1;PYGL;AMY2A5;UGT2B7;G6PCA.2
Retinol metabolism	UGT2B7;AOX3L1;HSD17B6;CYP2C50;UGT5G1;CYP3A41A;DGAT1A;CYP2C39;CYP26C1
Porphyrin and chlorophyll metabolism	UGT2A3;FECH;UGT2A2;HMOX1A;HMBSA;UGT1A1;UGT1A2;EARS2;HMOX2
Metabolism of xenobiotics by cytochrome P	GSTA1;GSTP1;UGT1A9;DHDH;GSTM3;GSTP2;GSTA2;AKR7A3;MGST1
Drug metabolism - cytochrome P	UGT1A1;AOX3;UGT5G1;GSTM4;ALDH3B1;UGT2A1;GSTO1;GSTA4;MGST1.1
Drug metabolism - other enzymes	DPYDB;TK1;TYMP;CDA;Ces2e;IMPDH2;UGT2B7;UGT1A2;HPRT1
Metabolic pathways	MTHFD2;MAT1A;PLA2G2E;PLCG2;COX6B2;Aldh1a7;P4HA3;ALOX12;ATP6V0A4
Chemical carcinogenesis	FAM84B;CYP3A7-CYP3AP1;AHA-1;UGT1A2;HSD11B1;ADH2-1;CYP3A41A;ADH4;UGT1A6A

UGT1A4 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A4 itself. We selected most functions UGT1A4 had, and list some proteins which have the same functions with UGT1A4. You can find most of the proteins on our site.

Function	Related Protein
enzyme binding	SIRT1;GSTM1;SUPT5H;PRKCA;RPA3;ATF7;HIST1H2AL;PYCARD;RPS19BP1
glucuronosyltransferase activity	UGT2A5;UGT5A5;UGT2A4;UGT1B2;UGT2B5;UGT2B7;CSGALNACT1;UGT8;UGT5D1
NOT glucuronosyltransferase activity	UGT1A6;UGT1A3;UGT1A9;UGT1A1;UGT1A7;UGT1A4
protein heterodimerization activity	DVL3;UGT1A6A;PPP2R1A;NEUROD2;TAP1;TPD52L1;H2-AA;ZHX2;CHRNA3
protein homodimerization activity	ADRB2;CADM3;IRF3;NOS1;NAGA;ACTN2;ZHX2;ACTN1;MAP3K12
NOT retinoic acid binding	UGT1A4;UGT2B7;UGT1A6;UGT2B15

UGT1A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A4.

CYB5A; q9wmx2-pro_0000037550

Research Area

Pretheeban, M; Hammond, G; et al. Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 159:159-166(2011).

Reimers, A; Ostby, L; et al. Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 35:79-82(2011).