UGT1A4
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A4 -
Overview
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. -
Synonyms
UGT1A4;UDP glucuronosyltransferase 1 family, polypeptide A4;UDP glycosyltransferase 1 family, polypeptide A4;UDP-glucuronosyltransferase 1-4;HUG BR2;UGT1D;Bilirubin UDP glucuronosyltransferase isozyme 2;Bilirubin-specific UDPGT isozyme 2;HUG-BR2;UD14_HUMAN;UDP glucuronosyltransferase 1 family polypeptide A4;UDP glycosyltransferase 1 family polypeptide A4;UDP-glucuronosyltransferase 1-D;UDP-glucuronosyltransferase 1A4;UDPGT 1-4;UDPGT;UGT-1D;UGT1*4;UGT1-04;UGT1.4;bilirubin UDP-glucuronosyltransferase isozyme 2
Recombinant Proteins
- Human
- Zebrafish
- HEK293
- Mammalian Cells
- E.coli
- Insect cells
- DDK
- Myc
- His
- Non
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UGT1A4-38H | Recombinant Human UGT1A4, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| UGT1A4-7724Z | Recombinant Zebrafish UGT1A4 | Mammalian Cells | Zebrafish | His |
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| UGT1A4-512HCL | Recombinant Human UGT1A4 293 Cell Lysate | HEK293 | Human | Non |
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| RFL21825HF | Recombinant Full Length Human Udp-Glucuronosyltransferase 1-4(Ugt1A4) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (29-534) |
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| UGT1A4-103H | Recombinant Human UGT1A4 Protein | Insect cells | Human |
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| UGT1A4-2109H | Recombinant Human UGT1A4 Protein (29-534 aa), His-tagged | E.coli | Human | His | 29-534 aa |
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| UGT1A4-3950HFL | Recombinant Full Length Human UGT1A4, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| UGT1A4-6011H | Recombinant Human UGT1A4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
UGT1A4 involved in several pathways and played different roles in them. We selected most pathways UGT1A4 participated on our site, such as Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Steroid hormone biosynthesis | COMTA,CYP2C38,HSD17B7,UGT1A2,SRD5A2B,UGT1A6B,CYP21A1,HSD17B6,UGT2A3,HSD17B12B |
| Drug metabolism - cytochrome P | AOX4,AOX3,GSTT2B,UGT1A7C,GSTT2,GSTAL,GSTA2,GSTA4,GSTT1,GSTM4 |
| Chemical carcinogenesis | GSTM4,EPHX1,GSTM6,GSTP2,CBR1,ALDH3A1,FAM84B,UGT2B15,CYP2A6,CYP2C70 |
| Starch and sucrose metabolism | PYGMA,UGT2A1,UGT1A6B,Amy1,UGT1A2,AMY1A,PYGL,UGT1A6,UGT1A7,AMY2A3 |
| Metabolism of xenobiotics by cytochrome P | GSTM7,GSTA3,HSD11B1,GSTM3,ALDH3B2,GSTP1,MGST3,GSTA5,UGT1A6B,GSTA |
| Metabolic pathways | IMPA2,MTMR7A,SUCLA2,PI4K2A,CYP11C1,HSD17B1,NT5C2A,HADHAB,PTGS1,ACO1 |
| Drug metabolism - other enzymes | NAT2,UGT2B15,CES1D,TYMP,TK1,UGT2A3,UMPS,UGT1A1,UGT1AB,CES1 |
| Pentose and glucuronate interconversions | UGP2,UGT2A1,UGP2A,DHDH,Akr1b3,UGT1A3,AKR1A1A,UGT2B15,DCXR,UGT1A7 |
| Ascorbate and aldarate metabolism | UGT2B15,UGT2A1,UGT1A2,UGT1A9,ALDH2.1,UGT1A6A,UGT1AB,UGT2B7,UGT1A7C,MIOX |
Protein Function
UGT1A4 has several biochemical functions, for example, enzyme binding,glucuronosyltransferase activity,NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A4 itself. We selected most functions UGT1A4 had, and list some proteins which have the same functions with UGT1A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT glucuronosyltransferase activity | UGT1A7,UGT1A1,UGT1A9,UGT1A6,UGT1A3 |
| NOT retinoic acid binding | UGT1A6,UGT2B15,UGT2B7 |
| enzyme binding | TRAF2,HSPA2,PRMT1,CBX4,PRKCH,LDB2,MAPK8,GNB2L1,DAXX,PARP4 |
| glucuronosyltransferase activity | UGT5A5,UGT1A6A,UGT1AB,UGT1A7C,UGT2B6,GYLTL1B,UGT1A9,UGT5B2,UGT1A7,UGT2B5 |
| protein homodimerization activity | THRA,MAPK4,ABCG2,BNIP3L,RBM44,TCF3B,STOM,PLEKHB1,TCF3A,FGFR1 |
| protein heterodimerization activity | CXorf15,CAPN2,SCGB2A1,MID2,TAF6L,NR4A2,UGT1A9,VAPA,TGFB1,HIST1H3A |
Interacting Protein
UGT1A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A4.
CYB5A;q9wmx2-pro_0000037550
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References
- Pretheeban, M; Hammond, G; et al. Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 159:159-166(2011).
- Reimers, A; Ostby, L; et al. Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 35:79-82(2011).
