UGT1A4

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UGT1A4

Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A4
Background This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
Synonyms UGT1A4; UDP glucuronosyltransferase 1 family, polypeptide A4; UDP glycosyltransferase 1 family, polypeptide A4; UDP-glucuronosyltransferase 1-4; HUG BR2; UGT1D; Bilirubin UDP glucuronosyltransferase isozyme 2; Bilirubin-specific UDPGT isozyme 2; HUG-BR2; UD14_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A4; UDP glycosyltransferase 1 family polypeptide A4; UDP-glucuronosyltransferase 1-D; UDP-glucuronosyltransferase 1A4; UDPGT 1-4; UDPGT; UGT-1D; UGT1*4; UGT1-04; UGT1.4; bilirubin UDP-glucuronosyltransferase isozyme 2
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cells
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A4-103H Recombinant Human UGT1A4 Protein Insect cells
    Human UGT1A4-2109H Recombinant Human UGT1A4 Protein (29-534 aa), His-tagged E.coli His
    Human UGT1A4-38H Recombinant Human UGT1A4, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A4-512HCL Recombinant Human UGT1A4 293 Cell Lysate HEK293 N/A
    Human UGT1A4-6011H Recombinant Human UGT1A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Zebrafish UGT1A4-7724Z Recombinant Zebrafish UGT1A4 Mammalian Cell His

    UGT1A4 involved in several pathways and played different roles in them. We selected most pathways UGT1A4 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions ALDH2.1; Akr1b3; ALDH3A2; UGP2B; UGT1A6A; UGT2A1; AKR1B7; SORD; UGT1A7; UGT2B7
    Ascorbate and aldarate metabolism UGT2A1; ALDH9A1A.1; UGT1AB; MIOX; ALDH9A1B; UGT1A6B; UGT1A6; GULO; UGT1A4; ALDH2.2
    Steroid hormone biosynthesis HSD17B1; HSD17B12A; STS; UGT1A7C; CYP2C39; UGT5G1; COMTA; CYP3A7-CYP3AP1; CYP3A41B; HSD3B5
    Starch and sucrose metabolism UGT1A6B; HK3; PGM2; G6PC2; GANC; AMY2A2; KL; UGT1A7; UGDH; UGP2B
    Retinol metabolism Aldh1a7; RETSATL; RDH10; LRATA; CYP2C50; RDH10A; BCO1; CYP2A12; CYP3A7-CYP3AP1; ADH1
    Porphyrin and chlorophyll metabolism HMBSB; HMOX2A; UGT2B15; ALAS2; FECH; UGT5G1; HCCSB; FXN; UGT1A1; UGT2A3
    Metabolism of xenobiotics by cytochrome P GSTT1B; UGT1A6A; GSTA1; CBR3; CBR1; SULT2A1; GSTM7; AKR7A2; UGT1A6B; UGT1A2
    Drug metabolism - cytochrome P UGT1A9; GSTT2; AOX1; FMO1; GSTT1; GSTA3; UGT1A4; UGT2A2; UGT2B7; GSTAL
    Drug metabolism - other enzymes PNAT10; UGT1A1; UGT1A7; GMPS; CES2; UGT1A3; TK1; Ces2c; NAT; UGT1A6
    Metabolic pathways PAFAH1B1B; FUT5; GLUL; RPN2; DNMT3AA; CYP2J5; INPP5K; PLCE1; NDUFS8; MGAT2
    Chemical carcinogenesis UGT1A6; ADH1; AKR1C2; PTGS2; CCBL2; ALDH3A1; NAT2; CYP2C39; ADH1C; ADH1A

    UGT1A4 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A4 itself. We selected most functions UGT1A4 had, and list some proteins which have the same functions with UGT1A4. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding USF1; BIRC5; TBP; RCOR3; MLEC; PRKCA; RCOR2; NLRP1; SIRT1; HMGA1-RS1
    glucuronosyltransferase activity UGT2B3; LARGE; UGT1A9; UGT2A1; UGT1A2; UGT1B7; EXT2; UGT1A7; UGT2A6; UGT1A3
    NOT glucuronosyltransferase activity UGT1A3; UGT1A6; UGT1A9; UGT1A1; UGT1A7; UGT1A4
    protein heterodimerization activity TAS1R1; HIST1H2AC; HIST1H4L; HIST1H4A; BMP7A; NEUROD2; MCL1A; SDCBP; NFYC; ATF2
    protein homodimerization activity TCF3B; BCL2A1A; SQSTM1; XDH; ECE1; DAPK3; NKX2-5; CEBPB; CRYBB2; VPS25
    NOT retinoic acid binding UGT1A4; UGT2B7; UGT2B15; UGT1A6

    UGT1A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A4.

    CYB5A; q9wmx2-pro_0000037550

    Pretheeban, M; Hammond, G; et al. Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 159:159-166(2011).
    Reimers, A; Ostby, L; et al. Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 35:79-82(2011).

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