Recombinant Human UGT1A4, MYC/DDK-tagged

Cat.No. : UGT1A4-38H
Product Overview : Recombinant Human UGT1A4, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
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Description : This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
Source : HEK293 cells
Species : Human
Molecular Mass : 57 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 [ Homo sapiens (human) ]
Official Symbol : UGT1A4
Synonyms : UGT1A4; UDP glucuronosyltransferase 1 family, polypeptide A4; UDPGT; UGT1D; UGT-1D; UGT1.4; HUG-BR2; UGT1-04; UDPGT 1-4; UDP-glucuronosyltransferase 1-4; UDP glycosyltransferase 1 family, polypeptide A4; UDP-glucuronosyltransferase 1-D; UDP-glucuronosyltransferase 1A4; bilirubin UDP-glucuronosyltransferase isozyme 2; bilirubin-specific UDPGT isozyme 2; NP_009051.1; EC
Gene ID : 54657
mRNA Refseq : NM_007120
Protein Refseq : NP_009051
MIM : 606429
UniProt ID : P22310
Chromosome Location : 2q37
Pathway : AhR pathway; Chemical carcinogenesis; Defective GSS causes Glutathione synthetase deficiency (GSS deficiency); Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Function : enzyme binding; enzyme inhibitor activity; NOT glucuronosyltransferase activity; glucuronosyltransferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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