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UGT1A7

Official Full Name

UDP glucuronosyltransferase 1 family, polypeptide A7
Overview

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
Synonyms

UGT1A7; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-7; UGT1G; GNT1; OTTHUMP00000065199; UD17_HUMAN; UDP glucuronosyltransferase 1A7; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A7; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1A7; UDPGT; UDPGT 1-7; UGT-1G; UGT1; UGT1*7; UGT1-07; UGT1.7; UDP glycosyltransferase 1 family, polypeptide A7;

Type

Recombinant Proteins

Species

Homo sapiens (Human)
Human
Zebrafish

Source

E.coli expression system
In vitro E. coli expression system
Insect cell
Insect cells
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UGT1A7-31664TH	Recombinant Human UGT1A7		N/A		Inquiry
Human	UGT1A7-982H	Recombinant Human UGT1A7 protein	Insect cell	N/A		Inquiry
Human	UGT1A7-102H	Recombinant Human UGT1A7 Protein	Insect cells			Inquiry
Human	UGT1A7-932H	Recombinant Human UGT1A7 Full Length Transmembrane protein, His-tagged	In vitro E. coli expression system	His	26-530aa	Inquiry
Homo sapiens (Human)	RFL5849HF	Recombinant Full Length Human Udp-Glucuronosyltransferase 1A7(Ugt1A7) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (26-530aa)	Inquiry
Zebrafish	UGT1A7-7715Z	Recombinant Zebrafish UGT1A7	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

UGT1A7 involved in several pathways and played different roles in them. We selected most pathways UGT1A7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	UGDH;ALDH3A2;UGT1A6A;ALDH2.2;AKR1B1L;AKR1B10;AKR1B7;DHDH;UGP2A
Ascorbate and aldarate metabolism	UGT1A3;UGT1A7;ALDH3A2A;UGT1A4;UGT1A6B;UGT1A1;ALDH3A2;UGT2A3;MIOX
Steroid hormone biosynthesis	CYP19A1B;HSD17B3;CYP3A41B;SRD5A3;SRD5A2A;UGT1A6;CYP7B1;HSD17B8;UGT2B7
Starch and sucrose metabolism	PGM1;UGT1A7C;ENPP1;UGT2B7;UGT1A9;GBA3;UGT2B15;UGT2A2;UGP2
Retinol metabolism	RDH8B;UGT2B7;CYP2C38;CYP3A65;RPE65C;UGT1A1;RDH5;ADH2-2;RETSAT
Porphyrin and chlorophyll metabolism	CPOX;UGT1A2;UGT2A1;HMOX2A;P22;UGT1A7C;HMBSB;ALAD;MMAB
Metabolism of xenobiotics by cytochrome P	GSTT1B;GSTO1;GSTM5;UGT1A7;UGT1A3;CBR1L;GSTA4;GSTM4;EPHX1
Drug metabolism - cytochrome P	ADH1;UGT1AB;GSTA5;ALDH3A1;MGST2;FMO4;MAOA;GSTT2;FMO3
Drug metabolism - other enzymes	UGT1A3;UGT2A3;IMPDH2;UMPS;UCKL1;TPMT;TPMT.1;CES1D;UPB1
Metabolic pathways	NADKD1;DNMT3B;XYLB;GM5506;LSM1;ALOX12;COX6A1;PNP5A;CSGALNACT2
Chemical carcinogenesis	GSTP1;CYP3A25;ADH2-1;GSTA3;GSTM1;UGT1A3;CYP2C9;CYP3A5;GSTM3

UGT1A7 has several biochemical functions, for example, drug binding, enzyme binding, enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A7 itself. We selected most functions UGT1A7 had, and list some proteins which have the same functions with UGT1A7. You can find most of the proteins on our site.

Function	Related Protein
drug binding	SRP54A;FOLR2;PIGC;GABRA1;NAMPT;CYP2C9;TLR8;FASN;DHODH
enzyme binding	GSTM7;UGT1A1;TAF10;SIRT3;CALU;KPNB1;TSPAN17;APP;RPA2
enzyme inhibitor activity	ANGPTL3;ATPIF1B;GCHFR;APBA3;PLN;PRPSAP1;SCG5;APOV1;UGT1A1
glucuronosyltransferase activity	UGT1B4;UGT2A1;UGT2A5;UGT8A;UGT2A4;UGT5B2;UGT1A9;UGT1AB;EXT2
NOT glucuronosyltransferase activity	UGT1A9;UGT1A1;UGT1A7;UGT1A4;UGT1A6;UGT1A3
protein heterodimerization activity	TYRP1;BCL2;TAF8;ZHX1;CLCF1;WHRN;ADD2;SLC51A;UGT1A3
protein homodimerization activity	TAP1;CITED1;EXT1;CBS;APOA4;RENBP;S100A10;CDH13;ABCD3
protein kinase C binding	ADD3;UGT1A7;YWHAG;PLEK;NELL2;SDC4;GLRX3;HDAC9;PAWR
retinoic acid binding	CRABP1B;CRABP2;CYP26A1;CRABP1;PTGDSB;RARA;UGT1A3;UGT1A2;CRABP1A

UGT1A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A7.

pkcepsilon_chlae_protein; PRKCE; epsilon-rack_chlae_protein

Research Area

Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).

Joy, MS; Boyette, T; et al. Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 66:1119-1130(2010).