UGT1A7
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A7 -
Overview
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. -
Synonyms
UGT1A7;UDP glucuronosyltransferase 1 family, polypeptide A7;UDP glycosyltransferase 1 family, polypeptide A6;UDP-glucuronosyltransferase 1-7;UGT1G;GNT1;OTTHUMP00000065199;UD17_HUMAN;UDP glucuronosyltransferase 1A7;UDP glucuronosyltransferase;UDP glycosyltransferase 1 family polypeptide A7;UDP-glucuronosyltransferase 1 family polypeptide A7s;UDP-glucuronosyltransferase 1-G;UDP-glucuronosyltransferase 1A7;UDPGT;UDPGT 1-7;UGT-1G;UGT1;UGT1*7;UGT1-07;UGT1.7;UDP glycosyltransferase 1 family, polypeptide A7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UGT1A7-31664TH | Recombinant Human UGT1A7 | Human | Non | Full L. |
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| UGT1A7-7715Z | Recombinant Zebrafish UGT1A7 | Mammalian Cells | Zebrafish | His |
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| RFL5849HF | Recombinant Full Length Human Udp-Glucuronosyltransferase 1A7(Ugt1A7) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (26-530aa) |
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| UGT1A7-102H | Recombinant Human UGT1A7 Protein | Insect cells | Human |
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| UGT1A7-932H | Recombinant Human UGT1A7 Full Length Transmembrane protein, His-tagged | E.coli | Human | His | Full L. 26-530aa |
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| UGT1A7-982H | Recombinant Human UGT1A7 protein | Insect Cells | Human | Non |
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Involved Pathway
UGT1A7 involved in several pathways and played different roles in them. We selected most pathways UGT1A7 participated on our site, such as Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pentose and glucuronate interconversions | ALDH3A2A,UGT1A2,UGT1A4,AKR1B8,UGT1A7C,UGT5G1,UGT1A3,DHDHL,UGT2B7,ALDH3A2 |
| Metabolism of xenobiotics by cytochrome P | SULT2A1,GSTA,CBR1,GSTM1,GSTM7,MGST1,UGT1A9,ALDH3B1,UGT1A6B,UGT2B15 |
| Retinol metabolism | CYP3A7,RDH12,ADH2-2,UGT2B7,ADH2-1,UGT1A6A,UGT1A6,CYP2B19,RDH10A,UGT1A9 |
| Drug metabolism - other enzymes | UGT1AB,NAT2,UCK2,Nat3,CES2,PNAT3,UCK1,HPRT1,NAT1,CES1D |
| Ascorbate and aldarate metabolism | UGT2B15,UGDH,UGT1A9,UGT1A6A,ALDH9A1A.1,UGT2B7,ALDH9A1B,UGT1A4,UGT1A6B,GULO |
| Starch and sucrose metabolism | GANC,GPI1,SI,UGP2B,GYS1,UGT2A2,PYGL,G6PC3,PGM1,UGT5G1 |
| Metabolic pathways | COQ3,B3GNT2B,DAO.1,ACAA1,ACSL4,ACAD8,PAPSS2B,DGKAA,XDH,NDUFA4L |
| Steroid hormone biosynthesis | SRD5A3,CYP2C70,HSD3B6,CYP2C37,CYP2D10,CYP3A65,SRD5A2B,UGT1A2,STS,CYP2C54 |
| Drug metabolism - cytochrome P | GSTM7,MGST3,UGT2B15,GSTM4,GSTP2,GSTM5,MGST2,GSTT2,UGT1A7C,GSTT1 |
Protein Function
UGT1A7 has several biochemical functions, for example, drug binding,enzyme binding,enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A7 itself. We selected most functions UGT1A7 had, and list some proteins which have the same functions with UGT1A7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | MTOR,SETD6,CHRNA7,PYGL,CHRNB2,DRD2,FNTB,SRP54,CHRM1,HTR2A |
| protein heterodimerization activity | NFYB,TCF12,POLE4,YWHAE,NEUROD2,GABRR1,HIST1H2AI,DMRT1,GCLM,MAFG |
| retinoic acid binding | CRABP2A,CRABP1,LCN12,LRAT,CRABP1A,CRABP2,CRABP2B,UGT1A3,NR2F2,CRABP1B |
| glucuronosyltransferase activity | UGT5G2,UGT1AB,UGT1A7C,UGT1A6B,UGT1A5,UGT3A2,UGT5C2,UGT2B3,UGT1A6A,UGT1A1 |
| NOT glucuronosyltransferase activity | UGT1A4,UGT1A6,UGT1A9,UGT1A3,UGT1A1 |
| enzyme binding | TBP,EGLN1,TULP3,VAPB,APBA3,RCOR1,SELS,MAP2K7,UGT1A4,H2AFX |
| protein homodimerization activity | INHBB,PRDX4,HIF1AN,MECOM,LGALS6,SP100,P2RX7,ABAT,TPR,SLC11A1 |
| enzyme inhibitor activity | ANGPTL3,ATPIF1A,KIAA1967,UGT1A9,PDE6G,TAE1,DGKZ,ATPIF1B,PPP1R12A,GCHFR |
| protein kinase C binding | GRK5,HINT1,DSP,HDAC5,HDAC7A,TIRAP,SDPRA,PKN1,GNB2L1,SQSTM1 |
Interacting Protein
UGT1A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A7.
pkcepsilon_chlae_protein;PRKCE;epsilon-rack_chlae_protein
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References
- Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).
- Joy, MS; Boyette, T; et al. Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 66:1119-1130(2010).
