• Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A7

  • Background

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
  • Synonyms

    UGT1A7; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-7; UGT1G; GNT1; OTTHUMP00000065199; UD17_HUMAN; UDP glucuronosyltransferase 1A7; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A7; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1A7; UDPGT; UDPGT 1-7; UGT-1G; UGT1; UGT1*7; UGT1-07; UGT1.7; UDP glycosyltransferase 1 family, polypeptide A7;
    • Type:
    • Recombinant Proteins
    • Species :
    • Human
    • Zebrafish
    • Source :
    • In vitro E. coli expression system
    • Insect cell
    • Insect cells
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A7-982H Recombinant Human UGT1A7 protein Insect cell N/A
    Human UGT1A7-102H Recombinant Human UGT1A7 Protein Insect cells
    Human UGT1A7-932H Recombinant Human UGT1A7 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His
    Human UGT1A7-31664TH Recombinant Human UGT1A7 N/A
    Zebrafish UGT1A7-7715Z Recombinant Zebrafish UGT1A7 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • UGT1A7 Related Articles

    UGT1A7 involved in several pathways and played different roles in them. We selected most pathways UGT1A7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversionsOXSR1;ALDH3A2A;AKR1B1;AKR1B1L;UGT5G1;UGT1A7C;UGT2A1;CRYL1;UGT1A4
    Ascorbate and aldarate metabolismRGN;UGT2A2;UGT5G1;MIOX;UGT1AB;UGT1A6;UGT1A9;UGT1A6A;ALDH9A1
    Steroid hormone biosynthesisCYP21A1;CYP2D26;UGT1A7C;CYP11C1;UGT2A3;SULT2B1;AKR1C3;HSD17B12B;HSD11B1
    Starch and sucrose metabolismUGT2B15;UGT1A7;GYS1;G6PC2;UGT1A2;AMY2B;UXS1;GPIA;AMY2A3
    Retinol metabolismUGT1A3;UGT2A1;AOX3L1;BCO1L;Aldh1a7;UGT2B7;ADH1;DHRS4;UGT2A3
    Porphyrin and chlorophyll metabolismHMOX1;HMOX1A;UGT1A6;UGT2A1;HMOX2;BLVRA;CPOX;UGT1A4;UGT2A3
    Metabolism of xenobiotics by cytochrome PUGT2B15;GSTA3;UGT2B7;MGST1.2;ALDH1A3;GSTP2;DHDHL;ALDH3B2;GSTT1
    Drug metabolism - cytochrome PUGT2B15;GSTO1;MGST1.1;UGT1A4;MGST3;ALDH3B2;GSTT1;FMO4;GSTM2
    Drug metabolism - other enzymesUCK2A;UGT1AB;DPYS;UGT1A6;UGT2A3;UCK2;UPP1;UGT1A6A;UCKL1
    Chemical carcinogenesisADH2-1;Nat3;CYP3A41A;GSTT1;GSTA1;PTGS2;SULT1A4;SULT1A2;UGT2A3

    UGT1A7 has several biochemical functions, for example, drug binding, enzyme binding, enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A7 itself. We selected most functions UGT1A7 had, and list some proteins which have the same functions with UGT1A7. You can find most of the proteins on our site.

    Function Related Protein
    enzyme inhibitor activityNOTCH1;OAZ2A;ARRB1;ATPIF1;WFIKKN1;APOV1;TAE1;OAZ2B;UGT1A9
    glucuronosyltransferase activityUGT5G2;UGT5A4;UGT5A3;UGT1A3;UGT3A1;UGT2A1;UGT2A6;UGT5A1;UGT1B7
    NOT glucuronosyltransferase activityUGT1A6;UGT1A7;UGT1A9;UGT1A3;UGT1A1;UGT1A4
    protein heterodimerization activitySNX6;KCNA3;DMRT1;PDSS1;CAPN2;PBX1;HIST1H2BP;CHRNA3;ADRB1
    protein homodimerization activityTCF3B;XPNPEP1;PLEKHB1;PITX2;ALS2;ABP1;TCF4;CAMK2G;SDS
    protein kinase C bindingPRKCB;PLEK;NELL2;SDPRA;HDAC5;HINT1;ADD3;TRPV4;TIRAP
    retinoic acid bindingLCN12;CYP26A1;CRABP2A;CRABP1;NR2F2;UGT1A1;UGT1A9;CRABP2;CRABP2B

    UGT1A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A7.

    pkcepsilon_chlae_protein; PRKCE; epsilon-rack_chlae_protein

    Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).
    Joy, MS; Boyette, T; et al. Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 66:1119-1130(2010).
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