UGT1A7 Protein


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Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A7
Background This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols.
Synonyms UGT1A7; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-7; UGT1G; GNT1; OTTHUMP00000065199; UD17_HUMAN; UDP glucuronosyltransferase 1A7; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A7; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1A7; UDPGT; UDPGT 1-7; UGT-1G; UGT1; UGT1*7; UGT1-07; UGT1.7; UDP glycosyltransferase 1 family, polypeptide A7
    • Species :
    • Homo sapiens (Human)
    • Human
    • Zebrafish
    • Source :
    • E.coli expression system
    • Insect cell
    • Insect cells
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A7-31664TH Recombinant Human UGT1A7 N/A Inquiry
    Zebrafish UGT1A7-7715Z Recombinant Zebrafish UGT1A7 Mammalian Cell His Inquiry
    Homo sapiens (Human) RFL5849HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1A7(Ugt1A7) Protein, His-Tagged E.coli expression system His Inquiry
    Human UGT1A7-102H Recombinant Human UGT1A7 Protein Insect cells Inquiry
    Human UGT1A7-982H Recombinant Human UGT1A7 protein Insect cell N/A Inquiry

    UGT1A7 involved in several pathways and played different roles in them. We selected most pathways UGT1A7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions AKR1B1L; UGT2A1; UGT1A3; UGT2A3; DHDH; ALDH2.2; AKR1B1; GKUP; SORD; AKR1B7
    Ascorbate and aldarate metabolism MIOX; UGT1A6; ALDH2.1; UGT2B7; GKUP; ALDH1B1; UGT5G1; ALDH3A2; ALDH3A2A; UGT2B15
    Steroid hormone biosynthesis CYP21A1; HSD11B1; UGT1A2; CYP1A; STS; CYP3A7-CYP3AP1; PPP1R2; COMTB; SRD5A3; HSD17B7
    Starch and sucrose metabolism AMY1B; GYS1; Amy1; UGP2; HK1; PYGB; AMY2A3; G6PCA.2; PGM1; GPIB
    Retinol metabolism CYP2C38; UGT1A4; UGT1A3; DHRS4; CYP2C50; RDH12; AOX4; SDR16C5B; UGT1A7; UGT2A2
    Porphyrin and chlorophyll metabolism CPOX; UGT1A6; COX15; EARS2; UGT5G1; COX10; PPOX; EPRS; UGT2A2; UROS
    Metabolism of xenobiotics by cytochrome P UGT2B7; AKR7A5; UGT2A1; GSTAL; MGST1; GSTM4; UGT1A6A; GSTA4; GSTM1; CYP1A
    Drug metabolism - cytochrome P GSTM4; FMO4; AOX3; UGT2A1; UGT1A9; ADH1; GSTM; UGT1A1; FMO3; UGT2A2
    Drug metabolism - other enzymes CES1D; DPYD; XDH; TPMT; UCK2A; PNAT3; UGT1AB; CES1C; UGT1A6B; CES2
    Chemical carcinogenesis ALDH3B1; UGT1A7C; CYP2C8; ADH1A; GSTP1; CYP2C9; CYP3A41B; GSTM6; PTGS2; MGST2

    UGT1A7 has several biochemical functions, for example, drug binding, enzyme binding, enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A7 itself. We selected most functions UGT1A7 had, and list some proteins which have the same functions with UGT1A7. You can find most of the proteins on our site.

    Function Related Protein
    drug binding Alb; GSTP2; UGT1A7; CHRNA7; CHKA; DRD4; CYP2D6; HTR2B; DRD3; GLRB
    enzyme binding CABYR; SLPI; CLSTN2; SUPT5H; CYP2C8; DVL1; HIST1H2AK; DIS3L; PPARG; GBP1
    enzyme inhibitor activity ATPIF1; KIAA1967; APBA3; ARRB1; CD46; OAZ2A; CALU; APOV1; PDE6G; UGT1A1
    glucuronosyltransferase activity UGT1A5; UGT8A; UGT5A5; CSGALNACT1; UGT5A4; UGT2B15; GYLTL1B; UGT5C2; UGT5A2; B3GAT3
    NOT glucuronosyltransferase activity UGT1A9; UGT1A7; UGT1A3; UGT1A6; UGT1A1; UGT1A4
    protein heterodimerization activity PPP2R4; HNF1A; CEBPB; ALG2; TCF12; PDX1; VAPB; AHR; MAPK4; HIST1H2BK
    protein homodimerization activity GDF7; RCHY1; GREM2; CAV2; GNB2L1; ANXA6; AOC3; MTPAP; PDCD6; TYMS
    protein kinase C binding HDAC5; DSP; NELL2; LDB3; DACT1; SQSTM1; CASQ2; PAWR; PDLIM5; PKN1
    retinoic acid binding CRABP2; UGT1A3; SERPINA5; UGT1A1; CRABP1B; LCN12; CRABP1; UGT1A9; CYP26B1; UGT1A7

    UGT1A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A7.

    pkcepsilon_chlae_protein; PRKCE; epsilon-rack_chlae_protein

    Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).
    Joy, MS; Boyette, T; et al. Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 66:1119-1130(2010).

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