UQCRC2

  • Official Full Name

    ubiquinol-cytochrome c reductase core protein II

  • Overview

    Ubiquinol-cytochrome c reductase core protein II is a protein that in humans is encoded by the UQCRC2 gene. Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), whi

  • Synonyms

    UQCRC2;ubiquinol-cytochrome c reductase core protein II;cytochrome b-c1 complex subunit 2, mitochondrial;QCR2;UQCR2;mitochondrial;Complex III subunit 2;Core protein II;Cytochrome b-c1 complex subunit 2;EC 1.10.2.2;QCR2_HUMAN;Ubiquinol cytochrome c reductase complex core protein 2 mitochondrial;Ubiquinol cytochrome c reductase core protein II;Ubiquinol-cytochrome-c reductase complex core protein 2

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Rat
  • Mammalian Cells
  • E.coli
  • HEK293
  • HT-1080
  • His
  • T7
  • Non
  • Avi
  • Fc

    Involved Pathway

    UQCRC2 involved in several pathways and played different roles in them. We selected most pathways UQCRC2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with UQCRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Huntingtons disease COX8A,COX6C,ATP5E,ATP5O,Casp3,DNAI2,COX5B,NDUFS6,NDUFV3,NDUFC1
    Cardiac muscle contraction UQCRC2B,COX7B,COX7C,CACNG3,COX4I2,ATP1B1B,FXYD2,COX6C,ACTC1,TPM4
    Oxidative phosphorylation NDUFS1,COX5AA,COX15,NDUFB2,ATP6V0A4,COX7A2A,ATP6V0D1,ATP5G3B,ATP6V1G2,ATP6V0A2B
    Parkinsons disease NDUFA4,ATP5C1,UBE2G2,NDUFA8,ATP5J,UBE1Y1,UBA1,NDUFB11,NDUFV3,SLC18A1
    Alzheimers disease NDUFS6,COX6B2,CDK5R1,UQCR11,CALM1,MAPK1,NDUFA3,MAPK3,NDUFV1,PPP3CC
    Non-alcoholic fatty liver disease (NAFLD) IRS1,MAPK9,PRKAA2,NDUFA12,CEBPA,COX7B2,TGFB1,NFKB1,TNF,NDUFS5
    Metabolic pathways PHGDH,Aldh1a7,CYP4A12A,MTHFR,GALCB,PLCB3,ATP6V1B1,ATP6V1G1,LTC4S,ATP6V0D1

    Protein Function

    UQCRC2 has several biochemical functions, for example, metalloendopeptidase activity,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UQCRC2 itself. We selected most functions UQCRC2 had, and list some proteins which have the same functions with UQCRC2. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding MANEA,ZMIZ2,USP44,PDLIM3,DEF8,NEIL1,MTA1,RNF34B,ATRX,GCH2
    protein binding VIPR1,CCDC42,ZNF436,FMR1,STOML2,NIPAL1,WIBG,EPS15,BARHL2,CTH
    protein complex binding NFKBIA,CDKN1A,LRRC16A,ST13,PPIB,PCSK2,AP2A2,GRIN2A,RARB,KLHL8
    metalloendopeptidase activity Adam6,ADAM18,MMP30,OMA1,MMP10,MMP11,ADAM19,ADAMTS3,PAPPAB,ADAM9

    Interacting Protein

    UQCRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UQCRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UQCRC2.

    UQCRC1;CACNA1A;a8k1f4_human;HLA-B;ARF6;15-deoxy-delta(12,14;RNH1;ATF2;Csk;HTT;ICT1;Ddb1;Rmdn3;P;HUWE1;Ercc6l;SLX1A

    Resources

    References

    • Hu, WH; Hausmann, ON; et al. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). JOURNAL OF NEUROCHEMISTRY 81:36-45(2002).

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