UQCRC2

  • Official Full Name

    ubiquinol-cytochrome c reductase core protein II

  • Overview

    Ubiquinol-cytochrome c reductase core protein II is a protein that in humans is encoded by the UQCRC2 gene. Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), whi

  • Synonyms

    UQCRC2;ubiquinol-cytochrome c reductase core protein II;cytochrome b-c1 complex subunit 2, mitochondrial;QCR2;UQCR2;mitochondrial;Complex III subunit 2;Core protein II;Cytochrome b-c1 complex subunit 2;EC 1.10.2.2;QCR2_HUMAN;Ubiquinol cytochrome c reductase complex core protein 2 mitochondrial;Ubiquinol cytochrome c reductase core protein II;Ubiquinol-cytochrome-c reductase complex core protein 2

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Rat
  • Mammalian Cells
  • E.coli
  • HEK293
  • HT-1080
  • His
  • T7
  • Non
  • Avi
  • Fc

    Involved Pathway

    UQCRC2 involved in several pathways and played different roles in them. We selected most pathways UQCRC2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with UQCRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Parkinsons disease NDUFA11,COX4I2,COX6A2,SNCA,ATP5D,NDUFC1,GNAI2,NDUFA1,NDUFA10,COX7B
    Cardiac muscle contraction CACNA2D2,TNNC1B,UQCRC1,TPM2,COX7A2,MYL2B,ATP1B1B,ATP1A2,CACNG7,CACNA1D
    Metabolic pathways CHPT1,CSAD,G6PC,B4GALT4,PGAM1,GFPT1,AANAT1,CNDP1,MDH1,GALNT13
    Non-alcoholic fatty liver disease (NAFLD) PRKAB1,UQCRH,SDHA,ADIPOR2,ADIPOQ,NDUFB5,NDUFA11,TRAF2,MAPK10,UQCRFS1
    Huntingtons disease NDUFA11,NDUFA1,NDUFB4,POLR2B,POLR2C,NDUFV3,DNAL1,VDAC2,NDUFC2-KCTD14,DNALC1
    Alzheimers disease COX8A,NDUFV2,NDUFA3,ATP5J,RYR3,BAD,APBB1,COX7B,NDUFA12,NDUFA9
    Oxidative phosphorylation ATP6V1C2,NDUFA5,PPA2,NDUFA6,ctaG,ATP6V1F,NDUFB3,ATP6V1G1,ATP6V0E2,NDUFA4

    Protein Function

    UQCRC2 has several biochemical functions, for example, metalloendopeptidase activity,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UQCRC2 itself. We selected most functions UQCRC2 had, and list some proteins which have the same functions with UQCRC2. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding ZDHHC17,RYBPB,CA13,TRIM14,IRGF4,COP1,ZFAND5,ZNRF2A,CCS,ZDHHC15A
    protein complex binding GIT2,CEBPA,ANKRD32,FADD,WASF1,PAFAH1B1,ANKRD54,CCNE1,ITPR1,IST1
    protein binding FAM49B,DNPEP,FLOT2,PPP1R15B,IL24,TMSB4Y,TMEM182,UBB,TMSB4X,USP17L2
    metalloendopeptidase activity MMP17,MMP12,ADAMTS16,BMP1B,ADAM10,ADAM30,UQCRC2B,C6AST4,ADAMTS10,PHEX

    Interacting Protein

    UQCRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UQCRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UQCRC2.

    UQCRC1;CACNA1A;a8k1f4_human;HLA-B;ARF6;15-deoxy-delta(12,14;RNH1;ATF2;Csk;HTT;ICT1;Ddb1;Rmdn3;P;HUWE1;Ercc6l;SLX1A

    Resources

    References

    • Hu, WH; Hausmann, ON; et al. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). JOURNAL OF NEUROCHEMISTRY 81:36-45(2002).

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