UQCRC2

  • Official Full Name

    ubiquinol-cytochrome c reductase core protein II

  • Overview

    Ubiquinol-cytochrome c reductase core protein II is a protein that in humans is encoded by the UQCRC2 gene. Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), whi

  • Synonyms

    UQCRC2;ubiquinol-cytochrome c reductase core protein II;cytochrome b-c1 complex subunit 2, mitochondrial;QCR2;UQCR2;mitochondrial;Complex III subunit 2;Core protein II;Cytochrome b-c1 complex subunit 2;EC 1.10.2.2;QCR2_HUMAN;Ubiquinol cytochrome c reductase complex core protein 2 mitochondrial;Ubiquinol cytochrome c reductase core protein II;Ubiquinol-cytochrome-c reductase complex core protein 2

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Rat
  • Mammalian Cells
  • E.coli
  • HEK293
  • HT-1080
  • His
  • T7
  • Non
  • Avi
  • Fc

    Involved Pathway

    UQCRC2 involved in several pathways and played different roles in them. We selected most pathways UQCRC2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with UQCRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-alcoholic fatty liver disease (NAFLD) UQCR11,PIK3CA,PKLR,NDUFS1,PIK3CB,ATF4,ITCH,NDUFA1,NDUFB6,GSK3B
    Parkinsons disease NDUFA1,NDUFS4,NDUFS5,NDUFB7,UBE1Y1,SLC25A4,NDUFB8,NDUFS1,NDUFA3,VDAC1
    Metabolic pathways POLR2C,NT5C1B,ADO,EXT1C,ADKB,ALDH4A1,DGKAA,GLUL,FH1,PNPO
    Huntingtons disease POLR2A,REST,Atp5g2,NDUFB3,NDUFB9,TAF4B,IFT57,NDUFS6,COX6C,NDUFS2
    Alzheimers disease COX7A2L,COX7B,COX7B2,HSD17B10,RYR3,PPP3CA,ATP2A3,IDE,MAPK3,CALML5
    Cardiac muscle contraction CACNA1SA,ACTC1,COX7A2L,UQCRC2B,ATP1A2A,MYH7,ATP1A1,TPM1,CACNG4,MYL2B
    Oxidative phosphorylation NDUFA9,mt-Atp8,NDUFB11,NDUFC1,NDUFA11,NDUFV1,ATP6V0C,UQCR10,ATP5IB,NDUFB2

    Protein Function

    UQCRC2 has several biochemical functions, for example, metalloendopeptidase activity,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UQCRC2 itself. We selected most functions UQCRC2 had, and list some proteins which have the same functions with UQCRC2. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity ADAM19,ADAM33,MEP1A,MMP9,ADAM23,MMP13,NRD1B,ADAMTS9,ADAMTS18,ADAM30
    protein binding FCGR2A,XRCC4,ZC3H15,NCOA2,CHMP1B,MAPT,VASNA,GOLPH3L,MECOM,FOXG1
    zinc ion binding SAMHD1,RARB,AKAP8,EHMT1A,LMO1,USP51,CAR6,PGLYRP5,MYLIPB,DEF8
    protein complex binding LZTFL1,CDKN1A,UQCRFS1,KAT6B,NCKAP1L,AP2B1,WRN,CD2AP,HTR2A,CDKN1B

    Interacting Protein

    UQCRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UQCRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of UQCRC2.

    UQCRC1;CACNA1A;a8k1f4_human;HLA-B;ARF6;15-deoxy-delta(12,14;RNH1;ATF2;Csk;HTT;ICT1;Ddb1;Rmdn3;P;HUWE1;Ercc6l;SLX1A

    Resources

    References

    • Hu, WH; Hausmann, ON; et al. Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP). JOURNAL OF NEUROCHEMISTRY 81:36-45(2002).

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