USP18
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Official Full Name
ubiquitin specific peptidase 18 -
Overview
Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD and JAMM enzymes (1,2). USP18 (also known as UBP43 -
Synonyms
USP18;ubiquitin specific peptidase 18;ubiquitin specific protease 18;ubl carboxyl-terminal hydrolase 18;hUBP43;ubl thioesterase 18;ubl thiolesterase 18;43 kDa ISG15-specific protease;ISG15-specific-processing protease;ISG43;UBP43
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| USP18-149H | Recombinant Human USP18 Protein, His tagged | Insect Cells | Human | His |
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| USP18-469HCL | Recombinant Human USP18 293 Cell Lysate | HEK293 | Human | Non |
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| USP18-11H | Recombinant Human USP18 Protein(1-372aa), His&Myc-tagged | E.coli | Human | His&Myc | 1-372aa |
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| USP18-12H | Recombinant Human USP18 protein, His-tagged | E.coli | Human | His | 1-372aa |
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| Usp18-32M | Active Recombinant Mouse Usp18 Protein, His-tagged | Insect Cells | Human | His | 47-368 a.a. |
|
Involved Pathway
USP18 involved in several pathways and played different roles in them. We selected most pathways USP18 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine Signaling in Immune system | GBP6,PEBP1,SAMHD1,GHRB,PEA15,TRIM6,RASGRP1,DUSP10,SPNA2,TRIM17 |
| Interferon Signaling | TRIM14,TRIM8,TRIM10,IFIT11,IFIT10,IFIT12,ADAR,IRF4,IFITM2,IFIT2 |
| Interferon alpha/beta signaling | ISG20,IRF9,IFIT2,BST2,IRF4,IFI6,XAF1,IRF6,IRF2,MX2 |
| Antiviral mechanism by IFN-stimulated genes | UBE2L6,EIF4G2A,ARIH1,EIF4A1,HERC5,NUP50,IFIT11,EIF4A2,KPNA5,IFIT10 |
| Immune System | TXNIPB,NLRP3,CTSK,KLC3,TRIM38,RNF135,CTSB,POLR3H,HERC5,RNF144B |
| ISG15 antiviral mechanism | EIF4G2,ARIH1,ARIH1L,EIF4G2A,MX2,KPNA3,IFIT11,IFIT14,KPNA5,IFIT8 |
Protein Function
USP18 has several biochemical functions, for example, ISG15-specific protease activity,cysteine-type endopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP18 itself. We selected most functions USP18 had, and list some proteins which have the same functions with USP18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PRMT5,TARBP2,TRAM2,JAGN1,MLC1,ZNF223,TOM1,RRP8,COL4A3,NEK2 |
| cysteine-type endopeptidase activity | CASP6L1,PSD,CTSSA,CTSB,CASP7,CTSJ,UCHL1,FMNL3,CASP2,CASP1 |
| ubiquitin-specific protease activity | USP48,USP42,IWS1,USP16,USP19,USP49,OTUD7A,OTUD5,FMNL3,USP1 |
Interacting Protein
USP18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP18 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP18.
ISG15;b4dyc6_human;SGTA;NME1;STIP1;IFNAR2;MLF1;MYL6;FKBP5;USP41;HSP90AB1;KDM3B;NUDCD3;q96be0_human
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