• Official Full Name

    ubiquitin specific peptidase 18

  • Overview

    Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD and JAMM enzymes (1,2). USP18 (also known as UBP43
  • Synonyms

    USP18; ubiquitin specific peptidase 18; ubiquitin specific protease 18; ubl carboxyl-terminal hydrolase 18; hUBP43; ubl thioesterase 18; ubl thiolesterase 18; 43 kDa ISG15-specific protease; ISG15-specific-processing protease; ISG43; UBP43;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human USP18-149H Recombinant Human USP18 Protein, His tagged Insect Cell N-His
Human USP18-469HCL Recombinant Human USP18 293 Cell Lysate HEK293 N/A
Human Usp18-32M Active Recombinant Mouse Usp18 Protein, His-tagged Insect cell His
Human USP18-11H Recombinant Human USP18 Protein(1-372aa), His&Myc-tagged E.coli N-His&C-Myc 1-372aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

USP18 involved in several pathways and played different roles in them. We selected most pathways USP18 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antiviral mechanism by IFN-stimulated genesIFIT12;EIF4G1;NUPL2;EIF4EB;EIF4E;EIF4A2;ARIH1L;KPNA4;ARIH1
Cytokine Signaling in Immune systemOSTN;FRS2B;DUSP2;GHRB;IRF4;IFIT11;RASGRP1;NRG4;NUPL2
ISG15 antiviral mechanismIFIT11;KPNA3;IFIT10;MX2;IFIT8;USP18;EIF4E3;HERC5;ARIH1
Interferon SignalingIFITM2;TRIM8;IFIT3;IRF6;GBP2;GBP6;ISG20;FCGR1B;IRF2
Interferon alpha/beta signalingMX2;IRF6;IFIT2;IFIT3;SAMHD1;USP18;ISG20;IRF2;GBP2
Regulation of IFNA signaling

USP18 has several biochemical functions, for example, ISG15-specific protease activity, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP18 itself. We selected most functions USP18 had, and list some proteins which have the same functions with USP18. You can find most of the proteins on our site.

Function Related Protein
ISG15-specific protease activity
cysteine-type endopeptidase activityUSP33;CFLARA;ATG4A;UCHL1;CASPA;USP43;CTSL.1;CASP7;CTLA2B
ubiquitin-specific protease activityVCPIP1;USP24;OTUD5;USP22;USP47;USP2A;BRCC3;USP17L2;USP9X

USP18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP18 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP18.

ISG15; b4dyc6_human; SGTA; NME1; STIP1; IFNAR2; MLF1; MYL6; FKBP5; USP41; HSP90AB1; KDM3B; NUDCD3; q96be0_human

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