USP18 involved in several pathways and played different roles in them. We selected most pathways USP18 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Antiviral mechanism by IFN-stimulated genes |
EIF4A1; KPNA5; JAK1; ARIH1; EIF4E3; EIF4E; KPNA3; NUP50; ARIH1L; IFIT8 |
| Cytokine Signaling in Immune system |
FGFR1B; XAF1; TRIM2; EIF4G2A; DUSP5; PTPRA; TAB1; HBEGF; FGF10B; IFIT11 |
| ISG15 antiviral mechanism |
ARIH1L; IFIT14; HERC5; KPNA4; IFIT8; EIF4E3; KPNA3; IFIT11; USP18; ARIH1 |
| Immune System |
DEFA1; GRAP2A; PVRL2L; SIGLEC6; IRF6; ASB18; RIPK3; TREX1; HBL3; PLD4 |
| Interferon Signaling |
TRIM3; IRF6; TRIM62; TRIM46; GBP4; HERC5; TRIM5; FCGR1B; IFI35; IFIT2 |
| Interferon alpha/beta signaling |
GBP2; IFITM3; SAMHD1; IFI27; IFIT2; IRF6; IFIT3; BST2; USP18; IRF4 |
| Regulation of IFNA signaling |
USP18 |
USP18 has several biochemical functions, for example, ISG15-specific protease activity, cysteine-type endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP18 itself. We selected most functions USP18 had, and list some proteins which have the same functions with USP18. You can find most of the proteins on our site.
| Function |
Related Protein |
| ISG15-specific protease activity |
USP18 |
| cysteine-type endopeptidase activity |
CTSSA; FAM49BA; CTSL1B; USP14; USP40; CTSBA; CTSM; USP18; CTSK; USP31 |
| protein binding |
NANOS3; MAGEE1; NFYC; GPR3; CITED1; C5orf13; TRIM3; PPARG; SIGLEC6; TTYH2 |
| ubiquitin-specific protease activity |
USP17L2; OTUD6A; MYSM1; USP22; USP34; UCHL5; USP1; COPS5; ZRANB1B; OTULIN |
USP18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP18 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP18.
ISG15; b4dyc6_human; SGTA; NME1; STIP1; IFNAR2; MLF1; MYL6; FKBP5; USP41; HSP90AB1; KDM3B; NUDCD3; q96be0_human
