VAV1

  • Official Full Name

    VAV1 vav 1 guanine nucleotide exchange factor
  • Synonyms

    VAV1;vav 1 guanine nucleotide exchange factor;VAV, vav 1 oncogene;proto-oncogene vav;vav 1 oncogene;VAV

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Bacteria
  • Sf9 Cells
  • HEK293
  • Mammalian Cells
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag

    Involved Pathway

    VAV1 involved in several pathways and played different roles in them. We selected most pathways VAV1 participated on our site, such as cAMP signaling pathway,Chemokine signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fc epsilon RI signaling pathway RAC1,MAPK3,TNF,VAV3,IL13,MAPK1,FYN,SOS1,AKT2,MAP2K3
    Fc gamma R-mediated phagocytosis ASAP1,LIMK1,INPP5D,LAT,MAPK3,RAC2,PRKCA,SCIN,PIP5K1B,PIK3CD
    Natural killer cell mediated cytotoxicity FCGR3B,FAS,FCER1G,SOS1,NFATC1,PTPN6,NRAS,VAV3,IFNA21,PIK3R1
    B Cell Receptor Signaling Pathway IKBKG,HRAS,MAP2K1,VAV2,CDK7,PPP3CA,NFKB1,CD19,BLK,CD72
    Regulation of Actin Cytoskeleton SSH1,PDGFAA,MSN,FGF17,MYL9B,ARHGEF7A,PAK7,PFN1,ITGAV,PIKFYVE
    Leukocyte transendothelial migration NCF1,ESAM,PXN,CLDN2,CLDN3,PTK2B,VAV2,MMP9,MYL9,CLDN20
    cAMP signaling pathway PDE3B,PDE4D,ROCK1,GRIN1,PPP1R12A,TNNI3,PTGER2,CREB3L1,MAPK9,PLD2
    Chemokine signaling pathway LYN,Ccl27a,PPBP,XCR1,ADRBK1,PAK1,RHOA,CCL26,CXCL10,CXCL16
    T cell receptor signaling pathway LAT,TEC,PIK3R3,MAPK13,NFATC3,GRB2,DBNLB,PTPN6,CD28,ZAP70

    Protein Function

    VAV1 has several biochemical functions, for example, Rac guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAV1 itself. We selected most functions VAV1 had, and list some proteins which have the same functions with VAV1. You can find most of the proteins on our site.

    Function Related Protein
    Rac guanyl-nucleotide exchange factor activity FARP2,ARHGEF2,PREX2,ALS2,ARHGEF4,DOCK2,SPATA13,VAV3,FARP1
    guanyl-nucleotide exchange factor activity EIF2B5,PREX1,RIC8A,SH2D3A,NET1,FGD6,SPATA13,DOCK4B,PRSS56,ARHGEF18
    metal ion binding HPDA,DAK,ESYT1,MORC2B,ZNF652,MIPEP,ZFP280D,PPP6C,ACSM5,GNAL
    protein binding DDX6,SEMA6A,PKP2,ARL3,RAPGEF6,SEPT12,SERTAD3,TACR1,BCL2L14,METTL13
    transcription factor activity, sequence-specific DNA binding ZNF493,MYC,TCF7L1A,MEF2A,GATA2B,FOXP2,FOXD3,ZFP161,NFIL3-6,NFE2L2

    Interacting Protein

    VAV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VAV1.

    SH3BP2;LCP2;ABL1

    VAV1 Related Signal Pathway

    Resources

    References

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