Recombinant Full Length Human VAV1 Protein, C-Flag-tagged
Cat.No. : | VAV1-919HFL |
Product Overview : | Recombinant Full Length Human VAV1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 98.1 kDa |
AA Sequence : | MELWRQCTHWLIQCRVLPPSHRVTW DGAQVCELAQALRDGVLLCQLLNNL LPHAINLREVNLRPQMSQFL CLKNIRTFLSTCCEKFGLKRSELFE AFDLFDVQDFGKVIYTLSALSWTPI AQNRGIMPFPTEEESVGDED IYSGLSDQIDDTVEEDEDLYDCVEN EEAEGDEIYEDLMRSEPVSMPPKMT EYDKRCCCLREIQQTEEKYT DTLGSIQQHFLKPLQRFLKPQDIEI IFINIEDLLRVHTHFLKEMKEALGT PGAANLYQVFIKYKERFLVY GRYCSQVESASKHLDRVAAAREDVQ MKLEECSQRANNGRFTLRDLLMVPM QRVLKYHLLLQELVKHTQEA MEKENLRLALDAMRDLAQCVNEVKR DNETLRQITNFQLSIENLDQSLAHY GRPKIDGELKITSVERRSKM DRYAFLLDKALLICKRRGDSYDLKD FVNLHSFQVRDDSSGDRDNKKWSHM FLLIEDQGAQGYELFFKTRE LKKKWMEQFEMAISNIYPENATANG HDFQMFSFEETTSCKACQMLLRGTF YQGYRCHRCRASAHKECLGR VPPCGRHGQDFPGTMKKDKLHRRAQ DKKRNELGLPKMEVFQEYYGLPPPP GAIGPFLRLNPGDIVELTKA EAEQNWWEGRNTSTNEIGWFPCNRV KPYVHGPPQDLSVHLWYAGPMERAG AESILANRSDGTFLVRQRVK DAAEFAISIKYNVEVKHIKIMTAEG LYRITEKKAFRGLTELVEFYQQNSL KDCFKSLDTTLQFPFKEPEK RTISRPAVGSTKYFGTAKARYDFCA RDRSELSLKEGDIIKILNKKGQQGW WRGEIYGRVGWFPANYVEED YSEYCTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transcription Factors |
Protein Pathways : | B cell receptor signaling pathway, Chemokine signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, T cell receptor signaling pathway |
Gene Name : | VAV1 vav guanine nucleotide exchange factor 1 [ Homo sapiens (human) ] |
Official Symbol : | VAV1 |
Synonyms : | VAV |
Gene ID : | 7409 |
mRNA Refseq : | NM_005428.4 |
Protein Refseq : | NP_005419.2 |
MIM : | 164875 |
UniProt ID : | P15498 |
Products Types
◆ Recombinant Protein | ||
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◆ Lysates | ||
VAV1-423HCL | Recombinant Human VAV1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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