Recombinant Human VAV1 Protein, GST tagged

• Cat.No.: VAV1-021H
• Product Overview: Recombinant human VAV1 SH3 domain (589-662) was expressed in E. coli cells using an N-terminal GST tag. The gene accession number is NM_005428.4.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 589-662 aa
• Description: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Purity: > 90%
• Stability: One year at –70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.
• Concentration: 0.2 μg/μL
• Shipping: Dry ice

Gene Information

• Gene Name: VAV1 vav 1 guanine nucleotide exchange factor [ Homo sapiens (human) ]
• Official Symbol: VAV1
• Synonyms: VAV1; vav 1 guanine nucleotide exchange factor; VAV, vav 1 oncogene; proto-oncogene vav; vav 1 oncogene; VAV
• Gene ID: 7409
• mRNA Refseq: NM_005428
• Protein Refseq: NP_005419
• MIM: 164875
• UniProt ID: P15498