VCP

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VCP

Official Full Name valosin containing protein
Background Valosin-containing protein (VCP) is a highly conserved and abundant 97 kDa protein that belongs to the AAA (ATPase associated with a variety of cellular activities) family of proteins. VCP assembles as a homo-hexamer, forming a ring with a channel at its
Synonyms VCP; valosin containing protein; transitional endoplasmic reticulum ATPase; IBMPFD; p97; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit; TERA; ALS14; MGC8560; MGC131997; MGC148092
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human VCP-195H Recombinant Human VCP Protein, GST-tagged Insect cell GST
    Human VCP-3656H Recombinant Human VCP, GST-tagged E.coli GST
    Human VCP-419HCL Recombinant Human VCP 293 Cell Lysate HEK293 N/A
    Human VCP-506H Recombinant Human VCP protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human VCP-6354H Recombinant Human VCP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human VCP-7934H Recombinant Human VCP protein, His & T7-tagged E.coli His/T7
    Mouse VCP-17998M Recombinant Mouse VCP Protein Mammalian Cell His
    Mouse Vcp-6911M Recombinant Mouse Vcp Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat VCP-6508R Recombinant Rat VCP Protein Mammalian Cell His
    Chicken VCP-3456C Recombinant Chicken VCP Mammalian Cell His
    Zebrafish VCP-11527Z Recombinant Zebrafish VCP Mammalian Cell His

    VCP involved in several pathways and played different roles in them. We selected most pathways VCP participated on our site, such as Protein processing in endoplasmic reticulum, Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum HSC70; CCDC102A; ERN1; MAN1A2; SEL1L2; UBQLN2; SAR1AB; RBX1; DNAJC5GB; CUL1B
    Legionellosis RAB1; RAB1A; BNIP3; EEF1G; HSPA1A; RAB1B; SAR1B; TLR5; BCL2L13; CXCL2

    VCP has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCP itself. We selected most functions VCP had, and list some proteins which have the same functions with VCP. You can find most of the proteins on our site.

    Function Related Protein
    ADP binding MYO9B; ABCG1; ERN1; GCLC; MYO18A; MYO7A; MYO6; PRKAG1; PKM; TAP1
    ATP binding RLN1; MAP3K3; LACE1B; C22orf28; HSPA4L; KIF16B; CHUK; FKBP4; ABCD3; EP400
    ATPase activity NSFA; MYO19; ABCD3B; PMS1; KIF6; KIF20A; KIF9; VPS4A; NSF; DQX1
    BAT3 complex binding USP13; AMFR; SGTA; VCP
    K48-linked polyubiquitin binding UBXN1; UFD1L; IKBKE; VCP
    MHC class I protein binding CD8B; TAPBP; TAP1; HLA-E; CD244; Pilrb1; ATP5A1; TUBB4B; PILRB2; CD8A
    deubiquitinase activator activity VCP
    identical protein binding CLDN4; SHANK1; SSNA1; HAND1; DNMT3A; HSPB1; PRPF3; NME1; BRAP; TRIM23
    lipid binding STARD7; DLC1; UNC119B; NME4; LPAR2; STARD8; FFAR1; GPIHBP1; EPN2; PITPNM3
    poly(A) RNA binding DMGDH; FAM120A; PPP1R2P9; MRPS12; EEF2; EIF2AK2; DDX17; GPATCH4; FAM50A; SNRPN
    polyubiquitin binding TNIP2; PSMD4; TNIP3; PSMD4B; SHARPIN; RAD23A; THRSP; BAG6; ZFAND6; DZIP3
    protein binding ABL2; DCTN5; NLRP12; NFAT5; EFNA4; FABP2; NR0B2; UPRT; PLXNC1; ENTPD3
    protein domain specific binding SP100; NLRP1; MLF1; OCLN; RAB27B; GABRR2; CBX3; TACC1; FOXH1; KCTD13
    protein phosphatase binding ITGA1; PPP1R3G; DRD1; CSK; ITPR1; ERBB2; JAK3; MVP; CDKN1B; DLG4
    ubiquitin protein ligase binding AMBRA1; YWHAE; HSPD1; CASP8; UCHL1; UBE2V1; SPG20; ACTG1; FANCL; KDM4A
    ubiquitin-like protein ligase binding DDRGK1; USP13; CDK5RAP3; VCP; CEBPB; TRIP4
    ubiquitin-specific protease binding VPS24; RAD23A; SELS; CHMP3; VCP; DERL1; SYVN1; PARK2; SART3; MARCH6

    VCP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCP here. Most of them are supplied by our site. Hope this information will be useful for your research of VCP.

    ATXN3; NSFL1C; UBXN6

    Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
    Mori, F; Watanabe, Y; et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: An immunohistochemical investigation of two cases. NEUROPATHOLOGY 34:140-147(2014).

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