VCP Protein

September 27-30, 2022

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VCP

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VCP

Official Full Name valosin containing protein
Background Valosin-containing protein (VCP) is a highly conserved and abundant 97 kDa protein that belongs to the AAA (ATPase associated with a variety of cellular activities) family of proteins. VCP assembles as a homo-hexamer, forming a ring with a channel at its
Synonyms VCP; valosin containing protein; transitional endoplasmic reticulum ATPase; IBMPFD; p97; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit; TERA; ALS14; MGC8560; MGC131997; MGC148092
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mamanlian cells
    • Mammalian Cell
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human VCP-195H Recombinant Human VCP Protein, GST-tagged Insect cell GST
    Human VCP-3656H Recombinant Human VCP, GST-tagged E.coli GST
    Human VCP-506H Recombinant Human VCP protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human VCP-7934H Recombinant Human VCP protein, His & T7-tagged E.coli His/T7
    Mouse VCP-17998M Recombinant Mouse VCP Protein Mammalian Cell His
    Rat VCP-6508R Recombinant Rat VCP Protein Mammalian Cell His
    Chicken VCP-3456C Recombinant Chicken VCP Mammalian Cell His
    Zebrafish VCP-11527Z Recombinant Zebrafish VCP Mammalian Cell His
    Human VCP-419HCL Recombinant Human VCP 293 Cell Lysate HEK293 N/A
    Human VCP-9955HFL Recombinant Full Length Human VCP protein, Flag-tagged Mamanlian cells Flag
    Human VCP-6354H Recombinant Human VCP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Vcp-6911M Recombinant Mouse Vcp Protein, Myc/DDK-tagged HEK293T Myc/DDK

    VCP involved in several pathways and played different roles in them. We selected most pathways VCP participated on our site, such as Protein processing in endoplasmic reticulum, Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum NFE2L2; UBE2D2L; SEL1L; BCAP31; UBE2D2; UBQLNL; SSR3; CRYABA; PDIA6; RNF185
    Legionellosis NFKB2; ITGAM; CASP7; HSF1; CXCL1; CASP1; PYCARD; EEF1G; MYD88; HSPD1

    VCP has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCP itself. We selected most functions VCP had, and list some proteins which have the same functions with VCP. You can find most of the proteins on our site.

    Function Related Protein
    ADP binding TAP1; PKM; APAF1; GLUD2; MYH10; HSP104; CHORDC1; ATP1A1; ABCG1; MIEF1
    ATP binding PKN2; NARS; SYN2A; MADD; LIMK2; MTHFD1B; AGAP2; STK25; NLRP4C; DHX35
    ATPase activity DNAHC8; KIF20B; KIF3CB; ABCD3B; HSPA1B; OLA1; KIF3C; CENPE; IDE; DYNC2H1
    BAT3 complex binding VCP; AMFR; USP13; SGTA
    K48-linked polyubiquitin binding UFD1L; IKBKE; UBXN1; VCP
    MHC class I protein binding Pilrb1; CD244; TUBB; VCP; ATP5B; LILRB2; TUBB4B; TAPBP; CD8B; LILRB1
    deubiquitinase activator activity VCP
    identical protein binding IGF2R; KCNH2; EPS15; CEP57L1; C1QTNF9; PLEKHH2; PLN; TOPBP1; RCAN1; STIM1
    lipid binding GLTP; PFN3; RUFY1; APOA4B.1; PTEN; GPIHBP1; LPAR2; STARD6; FAM125A; BAD
    poly(A) RNA binding RPL4; EIF3E; RBM6; G3BP1; ZAK; HIST1H4E; MRPL42; PPRC1; APOBEC3C; NOL11
    polyubiquitin binding FAM175B; DNAJB2; RAD18; SHARPIN; HDAC6; RAD23A; FAM175A; AGL; RAD23B; THRSP
    protein binding C2orf88; EPHA3; LRFN2; HOOK1; CASKIN1; PPIL1; HMG20B; UBXN11; HIST1H3A; STX11
    protein domain specific binding ARRB2; HIST1H4A; LAMP1; TWIST1; HIST1H4J; ITGA3; HIST1H4F; CBX3; DVL2; HOMER2
    protein phosphatase binding TRAF3; GNB2L1; TRAF2; CDKN1B; MAP2K7; ROS1; CSF1R; CDC27; DRD1A; STAT6
    ubiquitin protein ligase binding SMAD6; FZD6; GABARAPL2; GPR37; XRCC5; TRIOBP; TSG101; PTPN22; PER3; UBE2KB
    ubiquitin-like protein ligase binding VCP; CEBPB; DDRGK1; TRIP4; USP13; CDK5RAP3
    ubiquitin-specific protease binding SYVN1; CHMP3; BAG6; VPS24; RAD23A; DERL1; VCP; PARK7; AMFR; MARCH6

    VCP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCP here. Most of them are supplied by our site. Hope this information will be useful for your research of VCP.

    ATXN3; NSFL1C; UBXN6

    Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
    Mori, F; Watanabe, Y; et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: An immunohistochemical investigation of two cases. NEUROPATHOLOGY 34:140-147(2014).

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