vcp
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  • Official Full Name
  • valosin containing protein
  • Background
  • Valosin-containing protein (VCP) is a highly conserved and abundant 97 kDa protein that belongs to the AAA (ATPase associated with a variety of cellular activities) family of proteins. VCP assembles as a homo-hexamer, forming a ring with a channel at its
  • Synonyms
  • VCP; valosin containing protein; transitional endoplasmic reticulum ATPase; IBMPFD; p97; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit; TERA; ALS14; MGC8560; MGC131997; MGC148092
Cat.#:VCP-195HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VCP protein, GST-tagged
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Cat.#:VCP-3656HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VCP, GST-tagged
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Cat.#:VCP-506HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human VCP protein, MYC/DDK-tagged
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Cat.#:VCP-7934HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VCP protein, His & T7-tagged
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Cat.#:VCP-17998MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse VCP Protein
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Cat.#:VCP-6508RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat VCP Protein
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Cat.#:VCP-3456CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken VCP
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Cat.#:VCP-11527ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish VCP
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Cat.#:VCP-419HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human VCP 293 Cell Lysate
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Involved Pathway

VCP involved in several pathways and played different roles in them. We selected most pathways VCP participated on our site, such as Protein processing in endoplasmic reticulum, Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
HSPA1L; DNAJC1; DNAJC5G; RBX1; UBE2E2; DNAJB2; SYVN1; UBQLN4; TRAF2; SSR4
Legionellosis
IL12A; EEF1A2; NFKBIA; APAF1; NAIP6; CXCL3; C3; RAB1A; ITGAM; IL6

Protein Function

VCP has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCP itself. We selected most functions VCP had, and list some proteins which have the same functions with VCP. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein MYO18A; ACTA1; P2RY1; PKM; ME1; MYO9B; ADCK3; MIEF1; GCLC; ATP1A1
Function ATP binding
Related Protein KIF11; ERBB4A; STK24B; CSNK1G2; ATP1A4; DHX37; ABCB10; STK30; VPS4A; GRK4
Function ATPase activity
Related Protein ATAD2B; ABCB3L1; NSFB; RHOBTB3; PICK1; MYH7; IDE; KIF20B; ABCF3; ATAD1B
Function BAT3 complex binding
Related Protein VCP; USP13; AMFR; SGTA
Function K48-linked polyubiquitin binding
Related Protein UFD1L; UBXN1; IKBKE; VCP
Function MHC class I protein binding
Related Protein Pilrb1; BCAP31; LILRB2; ATP5B; DERL1; HLA-E; TAP1; CD244; ATP5A1; CD8A
Function deubiquitinase activator activity
Related Protein VCP
Function identical protein binding
Related Protein MRAP2; PDGFB; DAPK2; LYZ1; MCIN; C14orf166; CD74; ITGB3; HOMER1; IAPP
Function lipid binding
Related Protein AP2A2; FFAR1; DOK7; APOH; Alb; VCP; AMER2; PFN3; APOA4B.1; ACBD7
Function poly(A) RNA binding
Related Protein ELAVL1; STIP1; PA2G4; CORO1A; EIF2S1B; RSRC2; FASTKD1; RBMS1; ZCCHC8; CIRH1A
Function polyubiquitin binding
Related Protein EPS15; SHARPIN; PSMD4B; RAD23A; BRE; RAD23B; PSMD4A; RAD18; AGL; HDAC6
Function protein binding
Related Protein PCBD2; KCND2; PCGF6; PHF16; CCNG1; RRAGD; SERPINB1A; KHDC1B; KIF13B; FKBP4
Function protein domain specific binding
Related Protein SERPINB1A; YWHAQ; HIST4H4; TACC3; VCP; CTBP1; NR0B1; TRIM11; HIST1H4J; HIST1H4D
Function protein phosphatase binding
Related Protein CDC27; ITPR1; RPA3; PPARG; FLT4; MET; PPP1R3G; ROS1; LCK; ANAPC7
Function ubiquitin protein ligase binding
Related Protein HM13; PRKAR1A; C10orf46; FBXW7; UBE2L3; SCN5A; UBE2S; SMAD6; LC3; RALB
Function ubiquitin-like protein ligase binding
Related Protein USP13; DDRGK1; CDK5RAP3; TRIP4; CEBPB; VCP
Function ubiquitin-specific protease binding
Related Protein VCP; MARCH6; SYVN1; BAG6; DERL1; VPS24; PARK7; CHMP3; RAD23A; SELS

Interacting Protein

VCP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCP here. Most of them are supplied by our site. Hope this information will be useful for your research of VCP.
ATXN3; NSFL1C; UBXN6

VCP Related Articles

Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
Mori, F; Watanabe, Y; et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: An immunohistochemical investigation of two cases. NEUROPATHOLOGY 34:140-147(2014).