| Description : |
Enables several functions, including ATP hydrolysis activity; K48-linked polyubiquitin modification-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in ATP metabolic process; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process; aggresome assembly; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and synapse. Part of ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Is expressed in several structures, including cerebral cortex; early embryo; gonad; gut; and triceps surae muscle. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog (s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). |
| Source : |
E. coli |
| Species : |
Mouse |
| Tag : |
N-His |
| Form : |
Lyophilized powder/frozen liquid |
| Molecular Mass : |
92.28 kDa |
| Protein Length : |
Met1-Gly806 |
| Purity : |
> 90 % as determined by SDS-PAGE |
| Notes : |
For research use only. |
| Storage : |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
| Storage Buffer : |
Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
| Reconstitution : |
Reconstitute in sterile water for a stock solution. |
| Shipping : |
They are shipped out with dry ice/blue ice unless customers require otherwise. |
