Vsig4
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Official Full Name
V-set and immunoglobulin domain containing 4
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Overview
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. -
Synonyms
VSIG4; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; Z39IG; protein Z39Ig; Ig superfamily protein; complement receptor of the immunoglobulin superfamily; CRIg;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- CHO
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- Human Cell
- Mammalian cells
- C
- His
- Fc
- Avi
- GST
- hFc
- His (Fc)
- HlgG1 Fc
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Vsig4 Related Research Area
Vsig4 involved in several pathways and played different roles in them. We selected most pathways Vsig4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Vsig4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Vsig4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Vsig4 itself. We selected most functions Vsig4 had, and list some proteins which have the same functions with Vsig4. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | MAGI2;BCAS2;EPHA7;IL2RB;WTAP;MTMR14;ARR3;DENR;DGCR8 |
Vsig4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Vsig4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Vsig4.
PDK2
- Q&As
- Reviews
Q&As (6)
Ask a questionVSIG4 has a complex relationship with other genes or proteins, and can interact with other genes or proteins and participate in a variety of biochemical reactions.
There are no drugs that directly regulate VSIG4 levels, but they can affect VSIG4 expression and function by modulating the immune system.
Mutations in VSIG4 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.
VSIG4 plays an important role in tumor immunity, which can inhibit the activation and function of T cells and NK cells, thereby promoting tumor growth and metastasis.
Studying the regulatory mechanism of VSIG4 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.
The types of mutations in VSIG4 include point mutations, insertions/deletions, duplications, etc., which can cause structural and functional abnormalities of the protein.
Customer Reviews (3)
Write a reviewStable performance, excellent performance in a variety of experiments.
No side effects, high safety.
It has good antigenicity and can induce target immune response.
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