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WDR4

Official Full Name

WD repeat domain 4
Overview

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.
Synonyms

WDR4; WD repeat domain 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; TRM82; WD repeat-containing protein 4;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	WDR4-847H	Recombinant Human WD Repeat Domain 4, T7-tagged	E.coli	T7	1-266	Inquiry
Human	WDR4-348HCL	Recombinant Human WDR4 293 Cell Lysate	HEK293	Non		Inquiry
Mouse	Wdr4-6979M	Recombinant Mouse Wdr4 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Zebrafish	WDR4-6738Z	Recombinant Zebrafish WDR4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

WDR4 involved in several pathways and played different roles in them. We selected most pathways WDR4 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gene Expression	NR0B2A;DCP1B;GLS2B;COX6A1;ZNF625;SUPT16H;HNRNPL2;EEF1B2;ZNF2
tRNA modification in the nucleus and cytosol	TYW5;TRDMT1;TRMT44;LAGE3;PUS1;TRMT5;TRMT12;PUS7;CDKAL1
tRNA processing	TYW5;TYW1;THG1L;CDKAL1;TSEN2;TP53RK;CCDC76;POP1;QTRT1

WDR4 has several biochemical functions, for example, protein binding, contributes_to tRNA (guanine-N7-)-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR4 itself. We selected most functions WDR4 had, and list some proteins which have the same functions with WDR4. You can find most of the proteins on our site.

Function	Related Protein
protein binding	MPZL3;TMEM242;PPIL1;BMP2;TYR;EIF4G1;S100A2;PHF10;RASAL2
contributes_to tRNA (guanine-N7-)-methyltransferase activity	WDR4;METTL1

WDR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR4.

METTL1; RABGGTB; FAM118A; TERF1; TERF2

Research Area

Fraga, TR; Chura-Chambi, RM; et al. Refolding of the recombinant protein OmpA70 from Leptospira interrogans from inclusion bodies using high hydrostatic pressure and partial characterization of its immunological properties. JOURNAL OF BIOTECHNOLOGY 148:156-162(2010).

Wang, CX; Huang, CH; et al. Subcellular localization and functional analyses of structural domains of COP1 in transgenic tobacco. CHINESE SCIENCE BULLETIN 47:1250-+(2002).