WDR4

  • Official Full Name

    WD repeat domain 4

  • Overview

    This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    WDR4; WD repeat domain 4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; TRM82; WD repeat-containing protein 4;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WDR4-847H Recombinant Human WD Repeat Domain 4, T7-tagged E.coli T7
Human WDR4-348HCL Recombinant Human WDR4 293 Cell Lysate HEK293 N/A
Mouse Wdr4-6979M Recombinant Mouse Wdr4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish WDR4-6738Z Recombinant Zebrafish WDR4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

WDR4 involved in several pathways and played different roles in them. We selected most pathways WDR4 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionTAF1D;KIAA1456;ZNF18;DPY19L2;ZNF34;ZNF143A;HNRNPR;ZNF213;ZNF205
tRNA modification in the nucleus and cytosolLCMT2;KIAA1456;TYW3;WDR4;TRMT5;ALKBH8;TRMT12;TRMT44;PUS1
tRNA processingTYW5;FAM98B;ZBTB8OS;TSEN2;KIAA1456;RPP14;ADAT2;TRMT11;TRMT12

WDR4 has several biochemical functions, for example, protein binding, contributes_to tRNA (guanine-N7-)-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR4 itself. We selected most functions WDR4 had, and list some proteins which have the same functions with WDR4. You can find most of the proteins on our site.

Function Related Protein
protein bindingTBCD;CHMP1A;LOR;NELL2;FAM109B;ISG15;KLHDC4;ACVR1B;GPR77
contributes_to tRNA (guanine-N7-)-methyltransferase activityMETTL1;WDR4

WDR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR4.

METTL1; RABGGTB; FAM118A; TERF1; TERF2

Research Area

Related articles

Fraga, TR; Chura-Chambi, RM; et al. Refolding of the recombinant protein OmpA70 from Leptospira interrogans from inclusion bodies using high hydrostatic pressure and partial characterization of its immunological properties. JOURNAL OF BIOTECHNOLOGY 148:156-162(2010).
Wang, CX; Huang, CH; et al. Subcellular localization and functional analyses of structural domains of COP1 in transgenic tobacco. CHINESE SCIENCE BULLETIN 47:1250-+(2002).
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