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Recombinant Mouse Wdr4 Protein, Myc/DDK-tagged

Cat.No. : Wdr4-6979M
Product Overview : Purified recombinant protein of Mouse WD repeat domain 4 (cDNA clone MGC:35877 IMAGE:5027600), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.
  • Specification
  • Gene Information
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Description : Non-catalytic component of a methyltransferase complex required for the formation of N7-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA. Also required for the formation of N7-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs, such as let-7. Acts as a regulator of embryonic stem cell self-renewal and differentiation. Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 45.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Wdr4 WD repeat domain 4 [ Mus musculus (house mouse) ]
Official Symbol : Wdr4
Synonyms : Wdr4; WD repeat domain 4; Wh; mWH; AI415180; AI448349; D530049K22Rik; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4; WD40 repeat protein 4; protein Wuho homolog; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
Gene ID : 57773
mRNA Refseq : NM_021322
Protein Refseq : NP_067297
UniProt ID : Q9EP82

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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