WDR83

  • Official Full Name

    WD repeat domain 83

  • Overview

    This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
  • Synonyms

    MORG1; MGC4238; WD repeat domain-containing protein 83; MAPK organizer 1; mitogen-activated protein kinase organizer 1; WDR83; WD repeat domain 83;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WDR83-331HCL Recombinant Human WDR83 293 Cell Lysate HEK293 N/A
Human WDR83-2354H Recombinant Human WDR83 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human WDR83-2354H-B Recombinant Human WDR83 Protein Pre-coupled Magnetic Beads HEK293
Human WDR83-5286H Recombinant Human WDR83 Protein, GST-tagged Wheat Germ GST
Human WDR83-5983H Recombinant Human WDR83 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WDR83-1629HFL Recombinant Full Length Human WDR83 Protein, C-Flag-tagged Mammalian cells Flag
Mouse WDR83-18508M Recombinant Mouse WDR83 Protein Mammalian Cell His
Mouse WDR83-10154M Recombinant Mouse WDR83 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Wdr83-6988M Recombinant Mouse Wdr83 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse WDR83-10154M-B Recombinant Mouse WDR83 Protein Pre-coupled Magnetic Beads HEK293
Rat WDR83-6579R Recombinant Rat WDR83 Protein Mammalian Cell His
Rat WDR83-6235R-B Recombinant Rat WDR83 Protein Pre-coupled Magnetic Beads HEK293
Rat WDR83-6235R Recombinant Rat WDR83 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque WDR83-5207R Recombinant Rhesus monkey WDR83 Protein, His-tagged Mammalian Cell His
Rhesus Macaque WDR83-5020R-B Recombinant Rhesus Macaque WDR83 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque WDR83-5020R Recombinant Rhesus Macaque WDR83 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish WDR83-563Z Recombinant Zebrafish WDR83 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

WDR83 involved in several pathways and played different roles in them. We selected most pathways WDR83 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR83 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPSMD5;SPTB;HBEGF;SPNA1;CNKSR1;CSF2RA;DUSP9;SPRED3;MARK3
Axon guidancePAK1;ABLIM2;SLIT2;RAC1;COL4A3;KBTBD7;DUSP7;NRAS;EFNA2A
Cytokine Signaling in Immune systemLGALS9;IFIT10;SPNA1;IRF4;CRKL;OASL;TRIM48;TRIM26;KBTBD7
DAP12 interactionsDUSP5;LCP2A;FGF8B;JAK3;TREM1;DAB2IPB;KLB;AGO2;MARK3
DAP12 signalingDUSP5;NEFLB;SPTBN2;TRAT1;HBEGF;PRKAR1AA;SPRED3;PEA15A;FRS2B
Developmental BiologyPHB;JAK3;TRPC4;DCC;SALL4;BOC;EPHA2;GFRA1;IL17RD
Downstream signal transductionAGO3;SPTB;FGF10B;FGF20A;FRS2B;RASGRP4;PHB;FRS2A;FGF8B
Downstream signaling of activated FGFR1SPTB;AGO2;WDR83;PEA15;RASGEF1A;PHB;SPRED1;SPRED3;IL17RD

WDR83 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR83 itself. We selected most functions WDR83 had, and list some proteins which have the same functions with WDR83. You can find most of the proteins on our site.

Function Related Protein
protein bindingGBP5;DOK1;AGO2;KLF6;CITED2;GATA5;GRHL3;RBM23;YES1

WDR83 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR83 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR83.

KEAP1; SNRPC; SF3B4; PRPF8; UBL5; PPIL1; AQR; KDM1A; BAG2; HSPB1; CRK; CRK; HNRNPH2

Research Area

Related articles

Ono, K; Hayashi, H; et al. Uterine superficial serous carcinomas and extensive serous endometrial intraepithelial carcinomas: clinicopathological analysis of 6 patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:7979-7988(2014).
Zambonelli, P; Davoli, R; et al. SNPs detection in DHPS-WDR83 overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH. BMC GENETICS 14:-(2013).
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