wnt3
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  • Official Full Name
  • wingless-related MMTV integration site 3
  • Background
  • Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA). Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.
  • Synonyms
  • WNT3; wingless-related MMTV integration site 3; Int-4; Wnt-3; proto-oncogene Wnt-3; proto-oncogene Int-4; proto-oncogene protein Wnt-3;
Cat.#:WNT3-205HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human WNT3, StrepII-tagged
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Cat.#:WNT3-3738HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WNT3, His-tagged
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Cat.#:WNT3-5161HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human WNT3, GST-tagged
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Cat.#:WNT3-5160MTag:N/A
Source (Host):Cell cultureSpecies:Mouse
Product nameRecombinant Mouse WNT3
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Cat.#:WNT3-3658CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WNT3
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Cat.#:WNT3-6430ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WNT3
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Cat.#:WNT3-296HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human WNT3 293 Cell Lysate
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Involved Pathway

WNT3 involved in several pathways and played different roles in them. We selected most pathways WNT3 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
DKK1; NFATC3; PPP3CC; TBL1Y; WNT7AA; GSK3B; NFATC4; SFRP1; FZD9; PPP3R1
Hedgehog signaling pathway
PRKACBA; WNT8A; CSNK1G1; WNT7AA; CSNK1G2B; FBXW11; PTCH2; GSK3AA; WNT4; SKIA
Hippo signaling pathway
TEAD1; AFP; CRB2; SMAD2; ID2; TGFB3; BIRC2; YWHAB; WWC1; WNT5B
Signaling pathways regulating pluripotency of stem cells
WNT1; FGFR2; AXIN1; APC; ACVR2A; HRAS; LIFR; Fzd4; ACVR2B; JARID2
Melanogenesis
WNT11B; CAMK2D1; GNAO1; HRASA; WNT2BA; WNT5A; EDNRB2; MITF; PRKACAB; Fzd4
HTLV-I infection
ELK4; NFATC3; Il2; XBP1; PIK3R3; CRTC3; ANAPC11; HLA-DOB; AKT2; FZD2
Pathways in cancer
WNT6; RASGRP3; MAPK8; CCNA1; NFKBIA; CXCL12; COL4A1; WNT7A; BMP4; FGF17
Proteoglycans in cancer
IGF1R; SRC; HSPG2; CCND1; HIF1A; PXN; WNT10B; MMP2; GAB1; PPP1CC
MicroRNAs in cancer
MDM4; DNMT1; PRKCG; NRAS; TIMP3; MET; CCNG1; NOTCH2; Abcb1b; TP53
Basal cell carcinoma
LEF1; Shh; STK36; WNT3A; WNT16; SUFU; HHIP; PTCH1; GLI1; PTCH2

Protein Function

WNT3 has several biochemical functions, for example, frizzled binding, protein binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT3 itself. We selected most functions WNT3 had, and list some proteins which have the same functions with WNT3. You can find most of the proteins on our site.
Function
Related Protein
Function frizzled binding
Related Protein WNT4A; WNT2B; WNT8A; WNT11; SDCBP; FZD1; WNT7B; MYOC; WNT7AA; WNT10B
Function protein binding
Related Protein ROR1; JAK3; BSCL2; DYRK4; SNX15; NFS1; SRSF10; THAP11; SEC16B; SLC5A1
Function protein domain specific binding
Related Protein PRKCZ; TWIST1; IKBKG; YWHAE2; YWHAE1; RAPGEF3; ANGEL1; HIST1H4E; AIDA; LIN7B
Function receptor agonist activity
Related Protein WNT1; SFRP2; WNT3A; WNT10B; GAS6; GREM1; WNT2; VEGFA; WNT5A; WNT4

Interacting Protein

WNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT3.
FZD7

WNT3 Related Articles

Lighthouse, JK; Zhang, L; et al. MESD Is Essential for Apical Localization of Megalin/LRP2 in the Visceral Endoderm. DEVELOPMENTAL DYNAMICS 240:577-588(2011).
Ettenberg, SA; Charlat, O; et al. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:15473-15478(2010).

WNT3 Related Gene Family

WNT