|Official Full Name||wingless-type MMTV integration site family, member 6|
|Background||The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]|
|Synonyms||WNT6; wingless-type MMTV integration site family, member 6; protein Wnt-6;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
wnt6 involved in several pathways and played different roles in them. We selected most pathways wnt6 participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with wnt6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Wnt signaling pathway||VANGL2; WNT4; MAPK8B; PPP3R1B; ROCK2A; CAMK2G1; FZD3B; TP53; GPC4; RAC3B|
|Hedgehog signaling pathway||Shh; WNT2BA; CSNK1G2; CSNK1G2A; GLI2B; GLI3; GAS1A; GSK3AA; ZIC2A; FBXW11B|
|Hippo signaling pathway||CRB1; BIRC2; NF2; WNT3A; PPP1CA; CDH1; LATS1; PPP1CC; PPP2R1A; FZD6|
|Signaling pathways regulating pluripotency of stem cells||FZD5; SMAD1; HOXB1; MAPK3; PIK3R2; FZD1; GSK3B; KLF4; PIK3R5; PIK3CG|
|Melanogenesis||DCT; GSK3AA; WNT5B; TYRP1; CALM4; FZD5; EP300; CALM2B; WNT4A; PRKACAB|
|HTLV-I infection||CCND3; TBP; FZD1; PTTG1; NFKB2; WNT7B; PCNA; SMAD2; GM-CSF; HLA-DPA1|
|Pathways in cancer||RAC2; AHA-1; FADD; FZD8; FGF2; RARB; FGFR3; GNG5; BMP4; MAPK1|
|Proteoglycans in cancer||VEGFA; ANK2; IGF1; HRAS; PIK3R3; PTK2; MRAS; AKT2; DROSHA; SDC4|
|Basal cell carcinoma||SETD6; WNT2; WNT7A; WNT2B; TCF7L2; HHIP; DVL3; WNT5A; DVL2; FZD10|
wnt6 has several biochemical functions, for example, frizzled binding. Some of the functions are cooperated with other proteins, some of the functions could acted by wnt6 itself. We selected most functions wnt6 had, and list some proteins which have the same functions with wnt6. You can find most of the proteins on our site.
|frizzled binding||RNF43; WNT11R; RSPO3; DVL1; WNT7AA; WNT9B; WNT4; WNT4A; WNT4B; WNT5B|
wnt6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with wnt6 here. Most of them are supplied by our site. Hope this information will be useful for your research of wnt6.