XPC
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Official Full Name
xeroderma pigmentosum, complementation group C -
Overview
XPC is a component of the nucleotide excision repair (NER) pathway. XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. -
Synonyms
XPC;xeroderma pigmentosum, complementation group C;DNA repair protein complementing XP-C cells;RAD4;xeroderma pigmentosum group C protein;XPCC;p125;mutant xeroderma pigmentosum group C;XP3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XPC-18626M | Recombinant Mouse XPC Protein | Mammalian Cells | Mouse | His |
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| XPC-4231Z | Recombinant Zebrafish XPC | Mammalian Cells | Zebrafish | His |
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| XPC-10233M | Recombinant Mouse XPC Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| XPC-10233M-B | Recombinant Mouse XPC Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| XPC-848H | Recombinant Human XPC Protein (496-734 aa), His-tagged | E.coli | Human | His | 496-734 aa |
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Involved Pathway
XPC involved in several pathways and played different roles in them. We selected most pathways XPC participated on our site, such as Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with XPC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | ERCC2,COPS3,GTF2H4,GTF2H2,RFC2,COPS7A,USP45,RAD23A,INO80E,TFPT |
Protein Function
XPC has several biochemical functions, for example, DNA binding,damaged DNA binding,single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XPC itself. We selected most functions XPC had, and list some proteins which have the same functions with XPC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | PCBP1,SSBP3B,HNRNPK,BRCA2,MEIOB,XRCC2,RTF1,HMGB2,TDP2,PURB |
| damaged DNA binding | TP63,HMGB1,RAD18,HMGB2,PCNA,OGG1,ERCC3,POLK,XRCC5,RBBP8 |
| DNA binding | SOX21,SSH2B,ZFP865,CHD2,HIST1H4E,SALL1,ATRX,SOX15,TOX,INSM2 |
Interacting Protein
XPC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XPC here. Most of them are supplied by our site. Hope this information will be useful for your research of XPC.
Pou5f1;Rad23b;Ywhae
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References
- Dreze, M; Calkins, AS; et al. Monitoring Repair of UV-Induced 6-4-Photoproducts with a Purified DDB2 Protein Complex. PLOS ONE 9:-(2014).
- Bai, XF; Jin, F; et al. Clinicopathological significance and prognostic value of Xeroderma pigmentosum complementary group C (XPC) expression in sporadic breast cancer patients. MEDICAL ONCOLOGY 29:1543-1553(2012).
