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YTHDF2

Official Full Name

YTH domain family, member 2
Overview

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosme 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Synonyms

YTHDF2; YTH domain family, member 2; YTH domain family 2; YTH domain family protein 2; HGRG8; NY REN 2; 9430020E02Rik; CLL associated antigen KW 14; High glucose regulated protein 8; Renal carcinoma antigen NY REN 2; YTH domain family member 2; YTHDF 2; CLL-associated antigen KW-14; high-glucose-regulated protein 8; renal carcinoma antigen NY-REN-2; NY-REN-2;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E. coli
E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	YTHDF2-236HCL	Recombinant Human YTHDF2 293 Cell Lysate	HEK293	Non		Inquiry
Human	YTHDF2-3765H	Recombinant Human YTHDF2 protein, GST-tagged	E.coli	GST	339-565 aa	$319 / 25μg
Human	YTHDF2-5322H	Recombinant Human YTHDF2 protein(2-579aa), His-tagged	E. coli	His	2-579aa	Inquiry
Mouse	Ythdf2-4093M	Recombinant Mouse Ythdf2 Protein (Met1-Lys579, S238A, S419A), N-GST tagged	E.coli	GST	Met1-Lys579, S238A, S419A	Inquiry
Rhesus Macaque	YTHDF2-5245R	Recombinant Rhesus monkey YTHDF2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	YTHDF2-5058R	Recombinant Rhesus Macaque YTHDF2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	YTHDF2-5058R-B	Recombinant Rhesus Macaque YTHDF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

YTHDF2 involved in several pathways and played different roles in them. We selected most pathways YTHDF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with YTHDF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

YTHDF2 has several biochemical functions, for example, N6-methyladenosine-containing RNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YTHDF2 itself. We selected most functions YTHDF2 had, and list some proteins which have the same functions with YTHDF2. You can find most of the proteins on our site.

Function	Related Protein
N6-methyladenosine-containing RNA binding	YTHDF1;YTHDC1;YTHDF3;HNRNPC;YTHDF2
poly(A) RNA binding	CCDC137;Api5;YTHDC2;PFN1;UTP15;SUPT6H;RPL37A;CIRH1A;RBM7

YTHDF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YTHDF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of YTHDF2.

VCAM1; IRAK2; ssdna_dtdg; GABARAP; FN1; ESR1; RPL10; HIPK4; Hnrnpf

Research Area

Cardelli, M; Marchegiani, F; et al. A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 61:547-556(2006).